Pediatric HIV/AIDS & Infection-Related Malignancies Research Consortium for sub-Saharan Africa (PARCA)

儿童艾滋病毒/艾滋病

• 批准号: 10427340
• 负责人: CARL E ALLEN
• 金额: $ 110.38万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-25 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10427340
• 关键词: AIDS related cancer; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Adolescent; Affect; Africa South of the Sahara; African; Biometry; Botswana; Cancer Patient; Caring; Child; Childhood; Clinical Research; Collaborations; Complement; Country; Descriptive Epidemiology; Developmental Diagnostic; Diagnosis; Education; Epidemic; Fellowship; Fellowship Program; Goals; HIV; HIV Infections; HIV diagnosis; Healthcare; Hematological Disease; Hematology; Incidence; Infrastructure; International; Kaposi Sarcoma; Laboratories; Lead; Lymphoma; Malawi; Malignant Childhood Neoplasm; Malignant Neoplasms; Modeling; Oncology; Outcome; Patient-Focused Outcomes; Patients; Pediatric Hematology; Pediatric Hospitals; Pediatric Oncologist; Pediatric Oncology; Pediatric Oncology Group; Research; Research Project Grants; Research Training; Resource-limited setting; Resources; Risk; Risk Factors; Site; Texas; Training; Training Programs; Translational Research; Uganda; Work; base; cancer care; cancer epidemiology; cancer survival; career development; clinical infrastructure; design; improved; improved outcome; infection related cancer; medical specialties; mortality; operation; overtreatment; patient population; pediatric human immunodeficiency virus; pediatric patients; programs; risk stratification; success; training opportunity

Pediatric HIV/AIDS & Infection-Related Malignancies Research Consortium for Sub-Saharan Africa (PARCA) The goal of this proposal is to establish PARCA, a collaborative clinical and translational research framework designed with the overarching goal to improve the current unacceptably poor outcomes of children with HIV- associated malignancies in sub-Saharan Africa (SSA). Currently, over 80% of children with cancer in the US survive, whereas over 80% in the majority of SSA countries die. To begin to address this disparity and improve outcomes for children with cancer in SSA, Texas Children's Hospital leveraged the clinical infrastructure of BIPAI in Uganda, Malawi, and Botswana to establish Global HOPE (Hematology-Oncology Pediatric Excellence). Global HOPE is dedicated to excellence in the care and treatment of children globally with cancer and blood disorders through state-of-the-art treatments and cutting-edge research. These three Global HOPE pediatric cancer programs, which treat patients nationwide, have begun to transform cancer care in SSA. In the US, improvements in pediatric cancer survival were achieved largely through clinical and translational research coordinated by cooperative groups such as the Children's Oncology Group. Following that model, we propose to establish a framework for collaboration to enable advances for children in SSA living with HIV and diagnosed with cancer through PARCA. The Overarching Goals of the Consortium are to: 1. Define the descriptive epidemiology and infectious exposures related to pediatric malignancies in SSA. We will determine the incidence and outcomes of HIV-associated malignancy across the BIPAI network in SSA. 2. Conduct transformative inter-disciplinary collaborative research to reduce the burden of KS and lymphoma among children and adolescents in SSA. We will establish multi-center strategies for diagnosis, risk- stratification, and outcomes improvement for children with Kaposi sarcoma and lymphoma. These studies will be best conducted in Uganda, Malawi, and Botswana, where the pediatric patient population is large enough to establish meaningful results and conclusions. Validated results will be disseminated throughout our Global HOPE network, as it continues to expand operations in SSA. 3. Support the formation of a multi-national collaborative resource in clinical and translational research, training, and career development for African scientific leaders in HIV and pediatric cancer. We will provide myriad research and training opportunities for pediatric oncologists throughout SSA to participate in and lead translational and clinical research. This program of scientific training will complement and supplement the continued success of Global HOPE Paediatric Haematology and Oncology Fellowship Program.

撒哈拉以南非洲儿童艾滋病毒/艾滋病和感染相关恶性肿瘤研究联盟