Mentored Clinical Research to Improve Outcomes for Pediatric Mature B Cell Lymphoma in Uganda

指导临床研究以改善乌干达儿童成熟 B 细胞淋巴瘤的治疗结果

• 批准号: 10621584
• 负责人: CARL E ALLEN
• 金额: $ 12.5万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-25 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10621584
• 关键词: AIDS related cancer; AIDS/HIV problem; Accreditation; Address; Africa South of the Sahara; African; B-Cell Lymphomas; B-Cell NonHodgkins Lymphoma; Biologic Characteristic; Botswana; Caring; Child; Childhood; Clinical; Clinical Research; Clinical Trials Network; Country; Development; Diagnosis; Disease; Educational Curriculum; Enrollment; Epidemic; Fellowship; Fellowship Program; Foundations; Goals; HIV; Health Sciences; International; Malawi; Malignant Childhood Neoplasm; Mature B-Lymphocyte; Medicine; Mentors; Mentorship; NCI Center for Cancer Research; Oncology; Outcome; Parents; Patient-Focused Outcomes; Patients; Pediatric Cancer Care Network; Pediatric Hematology; Pediatric Hospitals; Pediatric Oncologist; Physicians; Research; Research Training; Site; Standardization; Tanzania; Texas; Training; Training Programs; Treatment Protocols; Uganda; Universities; college; experience; improved; improved outcome; infection related cancer; interest; lecturer; pediatric human immunodeficiency virus; pediatrician; programs; response; risk stratification

Project Summary/Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA- 22-036. Outcomes for children with cancer in sub-Saharan Africa (SSA) are unacceptably poor, with fewer than 20% of those diagnosed surviving. By contrast, over 85% of children with cancer in the US survive. The HIV epidemic complicates the landscape of pediatric malignancies in SSA. In partnership with collaborators in SSA, Global HOPE aims to lay the foundation for an international collaborative clinical trial network: Pediatric HIV/AIDS & Infection-Related Malignancies Research Consortium for Sub-Saharan Africa (PARCA). The central problem faced in SSA is the significant burden of HIV-associated malignancies in children and the poor survival of these patients. Global HOPE, a program developed by Baylor College of Medicine (BCM) and Texas Children’s Hospital (TCH), addresses systemic challenges to improve patient outcomes by facilitating the development of a network of pediatric cancer care and research centers across SSA, starting with sites in Uganda, Malawi, Botswana, and Tanzania. Global HOPE focuses on capacity-building and has partnered with the internationally recognized Makerere University College of Health Sciences (MakCHS) in Uganda to create a first-of-its-kind collaborative pediatric hematology-oncology (PHO) training hub. In 2016, Makerere College of Health Sciences (MakCHS) and Global HOPE implemented the first accredited PHO physician postgraduate clinical fellowship training program in SSA. To date, 24 pediatricians from eight African countries have enrolled in this two-year PHO fellowship training Program. Fourteen graduates from the program are currently leading PHO care teams at 7 centers in 4 countries in SSA. In this application, we propose to take advantage of PARCA to support clinical research training of Dr. Anne Akullo, a recent Ugandan graduate of the MakCHS PHO fellowship program, with a mentorship team including Dr. Ruth Namazzi (Lecturer, MakCHS, and Director of the Pediatric Hematology- Oncology Fellowship Program at Makerere University, Kampala, Uganda) and clinical research experts from Houston and Uganda. The overall goal of the parent U54 is to establish a standardized multi-site strategy to deliver safe and effective disease-specific and risk-stratified care to children with mature B cell non-Hodgkin lymphoma (MB-NHL) in SSA. Dr. Akullo’s training will include personalized curriculum and mentored research experience focusing on clinical research goals of Project #3 of the PARCA U54 in Uganda: To investigate clinical and biological characteristics associated with clinical outcomes of children with MB-NHL treated on standardized PARCA treatment regimens.

项目总结/文摘