Childhood Diabetes and Adiposity Research Training Program (C-DART)

项目摘要/摘要 儿童糖尿病和肥胖研究培训计划(C-DART)的目标是准备后 在临床、翻译或基础研究方面从事富有成效的临床、翻译或基础研究的博士内科科学家 1型和2型糖尿病以及肥胖、内脏过度和异位的其他代谢后果的治疗 儿童(如肝脏)脂肪沉积。培训计划在三个重要和积极的方面取得了进展 在本供资期间。第一，更新的名称(来自CDCMRT：儿童糖尿病临床和 分子研究培训计划)突出了对脂肪器官发育研究的扩展关注 而部位特异性脂肪沉积是卡路里过量不良代谢影响的关键危险因素 童年。其次，在过去10年成功的基础上，该项目既提炼了学员 将重点放在医学博士-科学家的研究性培训上，同时将申请范围扩大到包括学员 来自多个专业。第三，C-DART正在正式应用学习理论团队科学学习点， 严格评估和修改培训计划的每个组成部分。胰岛素抵抗，与 异位脂肪沉积和显性糖尿病，是儿童的一大健康问题。C-DART实习生可以开始 研究生涯从胰岛生物学和胰岛素抵抗的分子/细胞研究到整体 不同种族儿童肥胖症的身体病理生理学对儿童肥胖症防治的影响 青春年华。培训目标包括1)建立高质量和富有成效的研究项目，2)开发 同行评审出版物的成功记录，3)在T32期间提交外部资助建议 任期，如NIH K系列(或类似)，在C-DART后继续培训，以及4)过渡到成功 至少80%的毕业生从事以研究为重点的学术生涯。为了实现这些目标，一项研究 与美国国立卫生研究院资助的威斯康星大学研究所合作开发的Capstone证书课程 临床和转译研究(UW-卢旺达问题国际法庭)提供研究技术、统计和研究方面的培训 设计，负责任的研究行为，以及科学的写作和演示技能。C-DART研究培训 机会包括临床、翻译和基础科学活动，使学员接触到多学科的 对糖尿病和儿童肥胖相关疾病的研究。糖尿病和其他疾病不断增加的负担 肥胖相关的代谢紊乱，我们T32支持的受训人员10年来取得的强劲成绩， 以及认识到患有儿童期肥胖症和2型糖尿病的基础和临床科学研究人员的匮乏 培训促使我们继续为C-DART计划寻求资金。在拟议资助期内，C- 灾难援助队将继续利用现有资源和新战略，招募代表性不足的少数族裔受训人员 候选人。该计划将继续与从事创新工作的新的潜在导师建立合作关系 以及与儿童肥胖的发展和后果相关的尖端科学提供最新状态 为儿童糖尿病、胰岛素抵抗和肥胖症的富有成效的研究生涯提供指导的培训。

PROJECT SUMMARY/ABSTRACT The goal of the Childhood Diabetes and Adiposity Research Training program (C-DART) is to prepare post- doctoral physician scientists for productive careers in clinical, translational, or basic research in prevention or treatment of type 1 and 2 diabetes and other metabolic consequences of obesity and excess visceral and ectopic (e.g. hepatic) fat deposition in children. The training program has evolved in three important and positive ways during the current funding period. First, the updated name (from CDCMRT: Childhood Diabetes Clinical and Molecular Research Training Program) highlights the expanded focus on research in adipose organ development and site-specific adipose deposition as a key risk factor for adverse metabolic effects of calorie excess during childhood. Second, building on the success of the previous 10 years, the program has both refined its trainee focus to be the research training of MD physician-scientists while expanding applicant scope to include trainees from multiple specialties. Third, C-DART is applying learning theory Team Science Learning Points to formally, critically evaluate and modify each training program component. Insulin resistance, strongly associated with ectopic fat deposition and overt diabetes, is a major health problem in children. C-DART trainees can begin a research career ranging from molecular/cellular study of pancreatic islet biology and insulin resistance to whole body pathophysiology of childhood adiposity to prevention/treatment of childhood obesity in ethnically diverse youth. Training objectives include 1) establishing quality and productive research projects, 2) developing a successful record of peer-reviewed publications, 3) submitting proposals for extramural funding during T32 tenure such as NIH K series (or similar) to continue training after C-DART, and 4) transitioning to successful research-focused academic careers for at least 80% of graduates. To achieve these objectives, a research Capstone Certificate curriculum developed in collaboration with the NIH-funded University of Wisconsin Institute for Clinical and Translational Research (UW-ICTR) provides training in research techniques, statistics and study design, responsible conduct of research, and scientific writing and presentation skills. C-DART research training opportunities include clinical, translational, and basic science activities that expose trainees to a multi-disciplinary study of diabetes and diseases associated with childhood adiposity. The rising burden of diabetes and other obesity-related metabolic disorders, the strong 10-year record of accomplishment of our T32-supported trainees, and recognition of a scarcity of basic and clinical science researchers with childhood obesity and type 2 diabetes training prompt us to seek continued funding for the C-DART program. During the proposed funding period, C- DART will continue utilizing existing resources and new strategies to recruit underrepresented minority trainee candidates. The program will continue to build collaborations with new potential mentors engaged in innovative and cutting-edge science related to development and consequences of childhood adiposity to provide state-of- the-art mentored training for productive research careers in childhood diabetes, insulin resistance and obesity.