Childhood Diabetes and Adiposity Research Training Program (C-DART)

儿童糖尿病和肥胖研究培训计划 (C-DART)

• 批准号: 10427195
• 负责人: HUICHUAN J LAI
• 金额: $ 15.29万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10427195
• 关键词: Childhood diabetes; Research Training; Training Programs; obesity in children

PROJECT SUMMARY/ABSTRACT The goal of the Childhood Diabetes and Adiposity Research Training program (C-DART) is to prepare post- doctoral physician scientists for productive careers in clinical, translational, or basic research in prevention or treatment of type 1 and 2 diabetes and other metabolic consequences of obesity and excess visceral and ectopic (e.g. hepatic) fat deposition in children. The training program has evolved in three important and positive ways during the current funding period. First, the updated name (from CDCMRT: Childhood Diabetes Clinical and Molecular Research Training Program) highlights the expanded focus on research in adipose organ development and site-specific adipose deposition as a key risk factor for adverse metabolic effects of calorie excess during childhood. Second, building on the success of the previous 10 years, the program has both refined its trainee focus to be the research training of MD physician-scientists while expanding applicant scope to include trainees from multiple specialties. Third, C-DART is applying learning theory Team Science Learning Points to formally, critically evaluate and modify each training program component. Insulin resistance, strongly associated with ectopic fat deposition and overt diabetes, is a major health problem in children. C-DART trainees can begin a research career ranging from molecular/cellular study of pancreatic islet biology and insulin resistance to whole body pathophysiology of childhood adiposity to prevention/treatment of childhood obesity in ethnically diverse youth. Training objectives include 1) establishing quality and productive research projects, 2) developing a successful record of peer-reviewed publications, 3) submitting proposals for extramural funding during T32 tenure such as NIH K series (or similar) to continue training after C-DART, and 4) transitioning to successful research-focused academic careers for at least 80% of graduates. To achieve these objectives, a research Capstone Certificate curriculum developed in collaboration with the NIH-funded University of Wisconsin Institute for Clinical and Translational Research (UW-ICTR) provides training in research techniques, statistics and study design, responsible conduct of research, and scientific writing and presentation skills. C-DART research training opportunities include clinical, translational, and basic science activities that expose trainees to a multi-disciplinary study of diabetes and diseases associated with childhood adiposity. The rising burden of diabetes and other obesity-related metabolic disorders, the strong 10-year record of accomplishment of our T32-supported trainees, and recognition of a scarcity of basic and clinical science researchers with childhood obesity and type 2 diabetes training prompt us to seek continued funding for the C-DART program. During the proposed funding period, C- DART will continue utilizing existing resources and new strategies to recruit underrepresented minority trainee candidates. The program will continue to build collaborations with new potential mentors engaged in innovative and cutting-edge science related to development and consequences of childhood adiposity to provide state-of- the-art mentored training for productive research careers in childhood diabetes, insulin resistance and obesity.

项目概要/摘要 儿童糖尿病和肥胖研究培训计划 (C-DART) 的目标是为以后的研究做好准备 在预防或预防方面的临床、转化或基础研究方面从事富有成效的职业的博士医师科学家 治疗 1 型和 2 型糖尿病以及肥胖和过度内脏和异位引起的其他代谢后果 儿童（例如肝脏）脂肪沉积。培训计划以三个重要且积极的方式发展 在当前资助期内。首先，更新后的名称（来自CDCMRT：儿童糖尿病临床和 分子研究培训计划）强调了对脂肪器官发育研究的广泛关注 特定部位的脂肪沉积是卡路里过量产生不良代谢影响的关键危险因素 童年。其次，在过去10年成功的基础上，该项目既完善了学员 重点是医学博士医师科学家的研究培训，同时扩大申请人范围以包括受训人员 来自多个专业。第三，C-DART 正在将学习理论 Team Science Learning Point 正式应用于： 批判性地评估和修改每个培训计划的组成部分。胰岛素抵抗，与 异位脂肪沉积和明显的糖尿病，是儿童的主要健康问题。 C-DART 学员可以开始 研究生涯范围从胰岛生物学和胰岛素抵抗的分子/细胞研究到整体研究 儿童肥胖的身体病理生理学对不同种族儿童肥胖的预防/治疗 青年。培训目标包括 1) 建立高质量和富有成效的研究项目，2) 开发 同行评审出版物的成功记录，3) 在 T32 期间提交校外资助提案 终身教职，例如 NIH K 系列（或类似），以便在 C-DART 后继续培训，以及 4) 过渡到成功 至少 80% 的毕业生从事以研究为重点的学术职业。为了实现这些目标，一项研究 与 NIH 资助的威斯康星大学研究所合作开发的 Capstone 证书课程 临床和转化研究 (UW-ICTR) 提供研究技术、统计和研究方面的培训 设计、负责任的研究行为以及科学写作和演示技巧。 C-DART 研究培训 机会包括临床、转化和基础科学活动，让学员接触多学科 研究糖尿病和与儿童肥胖相关的疾病。糖尿病和其他疾病负担不断增加 与肥胖相关的代谢紊乱，我们 T32 支持的学员 10 年的出色成就记录， 并认识到儿童肥胖和 2 型糖尿病基础和临床科学研究人员的稀缺 培训促使我们为 C-DART 计划寻求持续的资金。在拟议的资助期内，C- DART 将继续利用现有资源和新战略来招募代表性不足的少数族裔实习生 候选人。该计划将继续与从事创新的新的潜在导师建立合作 以及与儿童肥胖的发展和后果相关的尖端科学，以提供最新状态 该艺术为儿童糖尿病、胰岛素抵抗和肥胖方面的富有成效的研究职业提供指导培训。