Childhood Diabetes and Adiposity Research Training Program (C-DART)

儿童糖尿病和肥胖研究培训计划 (C-DART)

• 批准号: 10188511
• 负责人: HUICHUAN J LAI
• 金额: $ 16.03万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10188511
• 关键词: Childhood diabetes; Research Training; Training Programs; obesity in children

PROJECT SUMMARY/ABSTRACT The goal of the Childhood Diabetes and Adiposity Research Training program (C-DART) is to prepare post- doctoral physician scientists for productive careers in clinical, translational, or basic research in prevention or treatment of type 1 and 2 diabetes and other metabolic consequences of obesity and excess visceral and ectopic (e.g. hepatic) fat deposition in children. The training program has evolved in three important and positive ways during the current funding period. First, the updated name (from CDCMRT: Childhood Diabetes Clinical and Molecular Research Training Program) highlights the expanded focus on research in adipose organ development and site-specific adipose deposition as a key risk factor for adverse metabolic effects of calorie excess during childhood. Second, building on the success of the previous 10 years, the program has both refined its trainee focus to be the research training of MD physician-scientists while expanding applicant scope to include trainees from multiple specialties. Third, C-DART is applying learning theory Team Science Learning Points to formally, critically evaluate and modify each training program component. Insulin resistance, strongly associated with ectopic fat deposition and overt diabetes, is a major health problem in children. C-DART trainees can begin a research career ranging from molecular/cellular study of pancreatic islet biology and insulin resistance to whole body pathophysiology of childhood adiposity to prevention/treatment of childhood obesity in ethnically diverse youth. Training objectives include 1) establishing quality and productive research projects, 2) developing a successful record of peer-reviewed publications, 3) submitting proposals for extramural funding during T32 tenure such as NIH K series (or similar) to continue training after C-DART, and 4) transitioning to successful research-focused academic careers for at least 80% of graduates. To achieve these objectives, a research Capstone Certificate curriculum developed in collaboration with the NIH-funded University of Wisconsin Institute for Clinical and Translational Research (UW-ICTR) provides training in research techniques, statistics and study design, responsible conduct of research, and scientific writing and presentation skills. C-DART research training opportunities include clinical, translational, and basic science activities that expose trainees to a multi-disciplinary study of diabetes and diseases associated with childhood adiposity. The rising burden of diabetes and other obesity-related metabolic disorders, the strong 10-year record of accomplishment of our T32-supported trainees, and recognition of a scarcity of basic and clinical science researchers with childhood obesity and type 2 diabetes training prompt us to seek continued funding for the C-DART program. During the proposed funding period, C- DART will continue utilizing existing resources and new strategies to recruit underrepresented minority trainee candidates. The program will continue to build collaborations with new potential mentors engaged in innovative and cutting-edge science related to development and consequences of childhood adiposity to provide state-of- the-art mentored training for productive research careers in childhood diabetes, insulin resistance and obesity.

项目总结/摘要 儿童糖尿病和肥胖症研究培训计划（C-DART）的目标是准备后， 博士医生科学家在临床，转化或基础研究的预防或生产性职业生涯 治疗1型和2型糖尿病以及肥胖和内脏和异位过多的其他代谢后果 (e.g.肝脏）脂肪沉积。培训计划在三个重要和积极的方面发展 在目前的融资期内。首先，更新名称（来自CDCMRT：儿童糖尿病临床和 分子研究培训计划）突出了对脂肪器官发育研究的扩大关注 和特定部位的脂肪沉积作为一个关键的危险因素的不利代谢影响的热量过剩， 童年.其次，在过去10年成功的基础上，该计划既完善了培训生， 重点是医学博士医生科学家的研究培训，同时扩大申请范围，包括学员 来自多个专业。第三，C-DART将学习理论团队科学学习点正式应用于， 严格评估和修改每个培训计划的组成部分。胰岛素抵抗，与 异位脂肪沉积和显性糖尿病是儿童的主要健康问题。C-DART学员可以开始 从胰岛生物学和胰岛素抵抗的分子/细胞研究到整个 不同种族儿童肥胖症的身体病理生理学与儿童肥胖症的预防/治疗 青年培训目标包括：1）建立高质量和富有成效的研究项目，2）开发 同行评审出版物的成功记录，3）在T32期间提交校外资助提案 任期，如NIH K系列（或类似）继续培训后，C-DART，和4）过渡到成功的 研究为重点的学术生涯至少80%的毕业生。为了实现这些目标，一项研究 与NIH资助的威斯康星州研究所大学合作开发的Capstone证书课程 临床和转化研究（UW-ICTR）提供研究技术，统计和研究方面的培训 设计、负责任的研究行为以及科学写作和演讲技巧。C-DART研究培训 机会包括临床，转化和基础科学活动，使学员接触多学科 糖尿病和与儿童肥胖症有关的疾病的研究。糖尿病和其他疾病的负担日益加重 肥胖相关的代谢紊乱，我们的T32支持的受训者10年来的成就记录， 以及认识到缺乏儿童肥胖和2型糖尿病的基础和临床科学研究人员 培训促使我们为C-DART计划寻求持续的资金。在拟议的供资期间，C- 灾难援助反应队将继续利用现有资源和新的战略来招募代表性不足的少数族裔受训人员 候选人该计划将继续与新的潜在导师建立合作， 与儿童肥胖症的发展和后果有关的尖端科学， 该技术指导了对儿童糖尿病、胰岛素抵抗和肥胖症的生产性研究职业的培训。