Animal Structure and Function

摘要 动物结构与功能核心 动物结构和功能核心为最先进的结构和功能提供了集中空间 动物功能测试，由专门的动物护理技术人员进行测试和培训 调查人员和他们的工作人员介绍了新设备的使用情况。该系的教职员工人数 进行动物结构和功能测试的眼科近年来发展迅速。使用 这一关键的调查人数，有令人信服的财务和后勤原因，以尽量减少 科学研究中的动物数量。使用眼睛成像方法使纵向 在活体动物身上进行观察可以大大减少在不同的时间点牺牲动物的需要 做实验。它还提供了非常有价值的信息，用于评估 人类的眼睛疾病。此外，视网膜成像设备的高成本使其令人望而却步 对于科学家个人来说，购买价格昂贵，因此限制了他们的科学研究范围。 该核心将提供一系列成像和功能测试服务，包括Micron IV Animal 具有多焦ERG和ERG设置的成像系统，Spectralis SDOCT系统用于光谱域光学 相干断层扫描和PacScan 300A-扫描仪测量前房眼轴长度的研究 深度和透镜厚度，超声成像使我们的研究人员能够最有效地利用他们的 时间和资源。

ABSTRACT Animal Structure and Function Core The Animal Structure and Function Core provides centralized space for state-of-the-art structural and functional animal testing with a dedicated animal care technician to conduct the testing and to train investigators and their staff on the use of the new equipment. The number of faculty in the Department of Ophthalmology conducting animal structure and functional testing has grown rapidly in recent years. With this critical mass of investigators, there are compelling financial and logistical reasons to minimize the number of animals in scientific studies. The use of ocular imaging methods that enable longitudinal observations in a living animal can greatly reduce the need to sacrifice animals at different time points in an experiment. It also provides invaluable information that is used to evaluate the accuracy of mouse models of human eye diseases. In addition, the high cost of retinal imaging devices has made it prohibitively expensive for individual scientist to purchase, therefore limiting the scope of their scientific investigations. This core will provide a range of imaging and functioning testing services including the Micron IV Animal Imaging System with multifocal ERG and ERG setup, Spectralis SDOCT system for spectral domain optical coherence tomography studies and PacScan 300 A-scanner for measuring axial length, anterior chamber depth and lens thickness, ultra sound imaging allowing our researchers to make most efficient use of their time and resources.