Animal Structure and Function

动物的结构和功能

• 批准号: 10709403
• 负责人: Dirk-Uwe G Bartsch
• 金额: $ 11.36万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709403
• 关键词: Animal Model; Animal Structures; Animal Technicians; Animal Testing; Animals; Center Core Grants; Collaborations; Communities; Dedications; Equipment; Eye; Eye diseases; Faculty; Image; Imaging Device; Individual; Investigation; Length; Measures; Ocular Physiology; Ophthalmology; Optical Coherence Tomography; Qualifying; Research Personnel; Resources; Scientist; System; Testing; Thick; Time; Ultrasonography; Vision; Vision research; animal care; animal imaging; anterior chamber; cost; experimental study; human model; imaging approach; imaging modality; imaging system; instrumentation; investigator training; lens; ocular imaging; retinal imaging; testing services

ABSTRACT Animal Structure and Function Core The Animal Structure and Function Core provides centralized space for state-of-the-art structural and functional animal testing with a dedicated animal care technician to conduct the testing and to train investigators and their staff on the use of the new equipment. The number of faculty in the Department of Ophthalmology conducting animal structure and functional testing has grown rapidly in recent years. With this critical mass of investigators, there are compelling financial and logistical reasons to minimize the number of animals in scientific studies. The use of ocular imaging methods that enable longitudinal observations in a living animal can greatly reduce the need to sacrifice animals at different time points in an experiment. It also provides invaluable information that is used to evaluate the accuracy of animal models of human eye diseases. In addition, the high cost of retinal imaging devices has made it prohibitively expensive for individual scientist to purchase, therefore limiting the scope of their scientific investigations. This core will provide a range of imaging and functioning testing services including the Phoenix Micron III and Phoenix Micron IV Animal Imaging System with multifocal ERG and ERG setup, new Celeris animal ERG system, Spectralis SDOCT system for spectral domain optical coherence tomography studies and PacScan 300 A-scanner for measuring axial length, anterior chamber depth and lens thickness, ultrasound imaging allowing our researchers to make most efficient use of their time and resources.

摘要 动物结构与功能核心 动物结构和功能核心为最先进的结构和功能提供了集中的空间。 功能性动物测试，由专门的动物护理技术员进行测试和培训 调查人员及其工作人员使用新设备的情况。系的教师人数 近年来，进行动物结构和功能检测的眼科学发展迅速。与 这一临界质量的调查人员，有令人信服的财政和后勤理由，以尽量减少 科学研究中的动物数量。使用眼部成像方法， 在活体动物中的观察可以大大减少在不同时间点处死动物的需要， 实验它还提供了宝贵的信息，用于评估动物模型的准确性， 人类的眼疾此外，视网膜成像设备的高成本使其望而却步， 科学家个人购买昂贵，因此限制了他们的科学范围 调查事务所该核心将提供一系列成像和功能测试服务，包括 Phoenix Micron III和Phoenix Micron IV动物成像系统，配备多焦ERG和ERG设置，全新 Spectralis动物ERG系统，用于光谱域光学相干断层扫描的Spectralis SDOCT系统 研究和PacScan 300 A扫描仪，用于测量轴长、前房深度和透镜厚度， 超声成像使我们的研究人员能够最有效地利用他们的时间和资源。