Mechanistic-Based Non-Invasive Assessment of Retinal Damage in HAART Era

HAART时代基于机制的视网膜损伤无创评估

• 批准号: 8526461
• 负责人: Dirk-Uwe G Bartsch
• 金额: $ 37.9万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8526461
• 关键词: 3-Dimensional; Algorithms; Appearance; Back; Biological Assay; Blindness; CD4 Lymphocyte Count; Characteristics; Clinic; Collection; Computational algorithm; Data; Data Set; Databases; Defect; Detection; Development; Dimensions; Disease; Drusen; Engineering; Exhibits; Eye; Goals; Grant; HIV; HIV Infections; HIV Seropositivity; Healed; Image; Laboratories; Lasers; Maps; Measures; Methods; Nervous System Trauma; Neuraxis; Neurologic; Neuropsychological Tests; Noise; Ophthalmoscopes; Optics; Patients; Phase; Process; Reporting; Research; Resolution; Retinal; Retinal Defect; Scanning; Signal Transduction; Testing; Thick; Tomogram; Vision; Work; adaptive optics; antiretroviral therapy; base; cotton wool spots; data acquisition; digital imaging; healing; improved; neurobehavioral; physical science; research study; retinal damage; statistics

DESCRIPTION (provided by applicant): Patients with HIV-disease continue to be treated with highly activated antiretroviral therapy (HAART). However, our research group and others have shown that vision loss and neurological loss continues to occur despite elevated CD4 counts. We have previously shown that we are able to visualize subtle retinal changes associated with healed cotton-wool spots (CWS) up to 16 years after the active phase. In this grant we plan to study the group of subjects that continue to exhibit neurological changes and retinal damage. Our hypothesis is that retinal damage is associated with neurological changes. Our first specific aim is to quantify retinal damage by high-resolution adaptive- optical corrected OCT. Our second specific aim is to develop a computer algorithm to map the defects associated with healed CWS. Our results have indicated that healed CWS demonstrate a characteristic restructuring of the retinal layers. This restructuring can be mapped in 3-D OCT images. The third specific aim is to correlate structural retinal defects with neurological markers collected by our collaborators at the UCSD's HIV Neurobehavioral Research Center. A possible correlation might help us by using retinal structural markers as indicators for neurological damage. Our team of collaborators includes experts on retinal imaging, computer processing, and neurobehavioral research.

描述（由申请人提供）：艾滋病患者继续接受高活性抗逆转录病毒疗法（HAART）治疗。然而，我们的研究小组和其他人已经表明，尽管CD 4计数升高，视力丧失和神经功能丧失仍在继续发生。我们之前已经证明，我们能够可视化与活动期后长达16年的愈合棉絮斑（CWS）相关的细微视网膜变化。在这项资助中，我们计划研究一组继续表现出神经系统变化和视网膜损伤的受试者。我们的假设是视网膜损伤与神经系统的变化有关。我们的第一个具体目标是通过高分辨率自适应光学校正OCT来量化视网膜损伤。我们的第二个具体目标是开发一种计算机算法来映射与愈合的CWS相关的缺陷。我们的研究结果表明，愈合的CWS表现出视网膜层的特征性重组。这种重构可以映射到3-D OCT图像中。第三个具体目标是将结构性视网膜缺陷与我们在UCSD的HIV神经行为研究中心的合作者收集的神经标志物相关联。一个可能的相关性可能有助于我们使用视网膜结构标记作为神经损伤的指标。我们的合作者团队包括视网膜成像、计算机处理和神经行为研究方面的专家。