Infectious Disease/Basic Microbial Pathogenic Mechanisms

项目摘要 这是一个申请更新传染病/基本微生物发病机制培训补助金， 华盛顿大学。随着大约50年前普遍可用的抗生素治疗的出现，许多 医生和科学家预测，传染病将不再是人们关注的一个主要健康领域。 随后的事件证明了这一预测是错误的，过去几十年来， 许多新发现的传染病，包括莱姆病，埃立克体病，SARS，COVID-19，西尼罗河 脑炎、基孔肯雅热、中东呼吸综合征、埃博拉和艾滋病毒。旧传染病的重新出现，如 疟疾和肺结核，以更致命和更耐抗生素的形式，也增加了公众的健康。 关注传染病带来的健康问题。很少有一个星期没有 关于新的传染病爆发的令人不安的标题。因此，远不是逐渐消失， 随着人们对健康问题的关注，传染病已经成为对健康问题越来越重要的问题。 的国家。当前病原体出现的抗生素耐药性和新病原体的出现 已经明确了增加对传染病各个方面的基础科学调查的必要性， 疾病华盛顿大学传染病/基础微生物培训项目的目的 发病机制是帮助满足这一需要，招募有前途的年轻调查人员到这一领域和培训 他们在杰出的研究计划与卓越的研究人员谁跨多个合作 学科（或在跨学科团队中发挥作用的人）进行传染病研究。我们的培训 该计划在过去40年中得到了NIH的支持，整合了来自四个部门的教师： 医学、儿科学、分子微生物学、病理学和免疫学。该方案提供培训， 医学博士，博士，M.D.博士博士后研究员和博士M.D.博士学生，在学科 与传染病的发病机制和宿主防御有关。项目导师的实验室 使用分子生物学、生物化学、遗传学、基因组学、免疫学、细胞生物学和翻译工具 药因此，该计划培养年轻的调查人员能够回答以下重要问题： 微生物致病机理，从基础生物学研究到临床应用。

PROJECT ABSTRACT This is an application to renew the Infectious Diseases/Basic Microbial Pathogenesis Training Grant from Washington University. With the advent of generally available antibiotic therapy about 50 years ago, many physicians and scientists predicted the end of infectious diseases as a major area of health concern. Subsequent events have proven this prediction wrong, and the past decades have seen the emergence of many newly identified infectious diseases, including Lyme Disease, erlichiosis, SARS, COVID-19, West Nile encephalitis, chikungunya, MERS, ebola and HIV. The reemergence of old infectious diseases, such as malaria and tuberculosis, in more virulent and more antibiotic resistant forms also has increased public attention on the health problems posed by infectious diseases. It is rare that a week goes by without some troubling headline concerning new infectious disease outbreaks. Thus, far from gradual disappearance as a health concern, infectious diseases have emerged as being of increasing importance to the health concerns of the nation. The emerging antibiotic resistance of current pathogens and the rise of new disease agents have made clear the necessity of increased fundamental scientific investigation into all aspects of infectious diseases. The purpose of the Washington University Training Program in Infectious Diseases/Basic Microbial Pathogenesis is to help fulfill this need by recruiting promising young investigators to this field and training them in outstanding research programs with preeminent investigators who collaborate across multiple disciplines (or who function in interdisciplinary teams) to perform infectious disease research. Our Training Program, which has had NIH support for the past 40 years, integrates faculty from four departments: Medicine, Pediatrics, Molecular Microbiology and Pathology & Immunology. The program provides training to M.D., Ph.D., and M.D./Ph.D. postdoctoral fellows, and to Ph.D. and M.D./Ph.D. students, in disciplines related to pathogenesis and host defense in Infectious Diseases. The laboratories of the program preceptors use tools of molecular biology, biochemistry, genetics, genomics, immunology, cell biology and translational medicine. Thus, the program trains young investigators to be able to answer the important questions of microbial pathogenesis, from studies of basic biology through application to the bedside.