INFECTIOUS DISEASE/BASIC MICROBIAL PATHOGENIC MECHANISMS

传染病/基本微生物致病机制

• 批准号: 8168716
• 负责人: Daniel E. Goldberg
• 金额: $ 1.06万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-10 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168716
• 关键词: Antibiotic Resistance; Antibiotic Therapy; Area; Attention; Avian Influenza; Bacterial Infections; Biochemistry; Biology; Biometry; Bioterrorism; Cellular biology; Clinical Research; Clinical Trials; Communicable Diseases; Computer Retrieval of Information on Scientific Projects Database; Discipline; Disease; Disease Outbreaks; Doctor of Medicine; Doctor of Philosophy; Encephalitis; Epidemiology; Event; Faculty; Funding; Genetic; Genomics; Grant; HIV; Health; Health behavior; Host Defense; Immunology; Infectious Diseases Research; Informatics; Institution; Investigation; Laboratories; Lyme Disease; Malaria; Medicine; Methods; Microbiology; Molecular; Molecular Biology; Outcomes Research; Pathogenesis; Pathology; Pediatrics; Physicians; Postdoctoral Fellow; Recruitment Activity; Research; Research Personnel; Resources; Scientist; Severe Acute Respiratory Syndrome; Source; Students; Training; Training Programs; United States National Institutes of Health; Universities; Virulent; Washington; West Nile virus; health economics; microbial; pathogen; patient oriented; programs; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. With the advent of generally available antibiotic therapy 40-50 years ago, many physicians and scientists predicted the end of infectious diseases as a major area of health concern. Subsequent events have proven this prediction wrong, and the past decades have seen the emergence of many newly identified infectious diseases, including Lyme Disease, erlichiosis, SARS, West Nile encephalitis, avian influenza, and HIV, as major health problems. The reemergence of old infectious diseases, such as malaria and bacterial infections, in new more virulent and more antibiotic resistant forms also has increased public attention on the health problems posed by infectious diseases. The threat of microbial bioterrorism has also come to the forefront. It is rare that a week goes by without some troubling headline concerning new infectious disease outbreaks. Thus, far from gradual disappearance as a health concern, infectious diseases have emerged in the past decade as being of even greater importance to the health concerns of the nation than previously. The emerging antibiotic resistance of current pathogens, the discovery of new disease agents, and the specter of bioterrorism have made clear the necessity of increased fundamental scientific investigation into all aspects of infectious diseases. The purpose of the Washington University Training Program in Infectious Diseases/Basic Microbial Pathogenesis is to help fulfill this need by recruiting promising young investigators to this field and training them in outstanding research programs with preeminent investigators who collaborate across multiple disciplines (or who function in interdisciplinary teams) to perform infectious disease research. Our Training Program, which has had NIH support for the past 25 years, integrates faculty from four departments: Medicine, Pediatrics, Molecular Microbiology and Pathology & Immunology. The program provides training to M.D., Ph.D., and M.D./Ph.D. postdoctoral fellows, and to Ph.D. and M.D./Ph.D. students, in disciplines related to pathogenesis and host defense in Infectious Diseases. The laboratories of the program preceptors use tools of molecular biology, biochemistry, genetics, genomics, immunology, and cell biology. The clinical research component includes epidemiology, biostatistics, clinical trials, outcomes research, health economics, health behavior research and informatics tools and methods to train patient-oriented and translational researchers. Thus, the program trains young investigators to be able to answer the important questions of microbial pathogenesis, from studies of basic biology through application to the bedside.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 随着40 - 50年前普遍可用的抗生素疗法的出现，许多医生和科学家预测传染病的终结是健康关注的主要领域。随后的事件证明了这一预测错误，过去几十年来，许多新发现的感染性疾病的出现，包括莱姆病，嗜酸症，SARS，西尼罗河脑炎，鸟类流感和艾滋病毒和艾滋病毒，是主要的健康问题。新的传染病（例如疟疾和细菌感染）的重新出现，在新的更具毒性和抗生素耐药性形式的情况下，人们对传染病所带来的健康问题的关注也增加了公众的关注。微生物生物恐怖主义的威胁也走到了最前沿。很少有一个星期没有关于新的传染病暴发的头条新闻。因此，在过去的十年中，传染病远非逐渐消失，而是对国家的健康关注更为重要。当前病原体的新兴抗生素耐药性，新的疾病药物的发现以及生物恐怖主义的幽灵已经明确表明，需要增加对传染病各个方面的基本科学研究的必要性。华盛顿大学传染病/基本微生物发病机理的培训计划的目的是通过招募有前途的年轻研究人员进入该领域来帮助满足这一需求，并与跨多学科合作（或在跨学科团队中运作）的杰出研究人员在杰出的研究计划中培训他们，以进行感染性疾病研究。在过去的25年中，我们的NIH支持了我们的培训计划，整合了来自四个部门的教职员工：医学，儿科，分子微生物学和病理学和免疫学。该计划为医学博士，博士学位和M.D./ph.d提供培训。博士后研究员和博士学位和M.D./PH.D。学生，与传染病中的发病机理和宿主防御有关的学科。程序受体的实验室使用分子生物学，生物化学，遗传学，基因组学，免疫学和细胞生物学工具。临床研究组成部分包括流行病学，生物统计学，临床试验，成果研究，健康经济学，健康行为研究和信息学工具以及培训以患者为导向和转化研究人员的方法。因此，该计划训练年轻的研究人员能够回答微生物发病机理的重要问题，从基本生物学到应用到床边。