Emory/Georgia TB Research Advancement Center (TRAC)

埃默里/格鲁吉亚TRAC的基础和转化科学（基础科学）核心将提供专业知识 和资源，以促进TRAC分支杆菌致病机制，传播和 结核分枝杆菌（Mtb）感染人类和动物模型中宿主免疫。基本 科学核心将利用TRAC社区现有的一套独特资源，包括 耶基斯国家灵长类动物研究中心，有能力在啮齿动物和非人类中进行结核分枝杆菌研究 灵长类动物，以及拥有大量动物BSL 3实验室空间的格鲁吉亚大学动物健康研究中心 和能力进行分枝杆菌感染和疫苗接种研究，在各种大，中， 小动物。基础科学核心的总体使命是提供实验室专业知识，培训， 促进创新性多学科和高度协作的结核病研究机会的资源 项目涉及基础科学核心教师，早期研究人员和已建立的研究人员 是结核病领域的新发现核心将通过提供培训、咨询和服务来实现这些目标， 最先进的实验室设备，设施和方法，包括最新的免疫学和 微生物测定和动物Mtb感染模型，除了提供质量控制的中心 TRAC社区的材料库。在目标1中，实验设计和实验室咨询 分析方法将提供给计划进行基础和转化科学研究的研究人员， Mtb.具体的培训领域将包括结核分枝杆菌培养和体外感染;结核分枝杆菌感染的动物;和实验室 分析培训、数据解释和方案开发。在目标2中，核心预算将向TRAC提供支助 调查人员为内部和外部资金申请提供初步的实验室数据; 进行实验室化验和动物结核分枝杆菌感染及疫苗接种研究，以支持TRAC系列 发展奖和其他资助项目;并支持新微生物学的发展， 基于免疫学实验室的测定。在目标3中，将建立一个生物储存库和电子数据库， 将来自一系列结核分枝杆菌感染和疾病的人类队列的临床标本和分离株存档 国家; Mtb感染动物和对照动物的标本; TRAC使用的常见Mtb实验室菌株 investigators.总之，基础科学核心将在培训、服务和 向埃默里/格鲁吉亚TRAC调查人员提供材料，总体目标是支持TRAC调查人员， 成功建立和扩大创新研究项目，填补结核病领域的关键知识空白 发病机制、传播和免疫，以更有效地抗击全球结核病大流行。

The Basic & Translational Science (Basic Science) Core of the Emory/Georgia TRAC will provide expertise and resources to facilitate TRAC investigator-led studies of mycobacterial pathogenesis, transmission, and host immunity in both human and animal models of Mycobacterium tuberculosis (Mtb) infection. The Basic Science Core will capitalize on a unique set of resources available to the TRAC community, including the Yerkes National Primate Research Center with capacity to conduct Mtb studies in rodents and nonhuman primates, and the University of Georgia Animal Health Research Center with extensive animal BSL3 lab space and capacity to conduct mycobacterial infection and vaccination studies in a variety of large, medium, and small animals. The overall mission of the Basic Science Core is to provide laboratory expertise, training, and resources to catalyze opportunities for innovative multidisciplinary and highly collaborative TB research programs engaging Basic Science Core faculty, early-stage investigators, and established investigators who are new to the TB field. The Core will achieve these goals by providing training, consultation, and services with state-of-the-art laboratory equipment, facilities, and methods, including the newest immunological and microbiological assays and animal Mtb infection models, in addition to providing a quality-controlled central repository of materials for the TRAC community. In Aim 1, consultation in experimental design and laboratory assay approaches will be provided to investigators who are planning basic and translational science studies of Mtb. Specific training areas will include Mtb culture and in vitro infection; Mtb infection of animals; and lab assay training, data interpretation, and protocol development. In Aim 2, the Core will provide support to TRAC investigators to generate preliminary laboratory-based data for internal and external funding applications; conduct laboratory assays and animal Mtb infection and vaccination studies in support of TRAC-series Developmental awards and other funded projects; and support the development of new microbiology and immunology laboratory-based assays. In Aim 3, a biorepository and electronic database will be established for archiving clinical specimens and isolates from human cohorts across a range of Mtb infection and disease states; specimens from Mtb-infected and control animals; and common Mtb laboratory strains for use by TRAC investigators. In summary, the Basic Science Core will provide value-added activities in training, services, and materials to Emory/Georgia TRAC investigators, with the overall goal of supporting TRAC investigators to successfully establish and expand innovative research programs filling critical knowledge gaps in TB pathogenesis, transmission, and immunity to more effectively combat the global TB pandemic.