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Emory/Georgia TB Research Advancement Center (TRAC)

埃默里/佐治亚州结核病研究促进中心 (TRAC)

基本信息

批准号：
10596180
负责人：
Cheryl Liane Day
金额：
$ 20.07万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-23 至 2027-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10596180
关键词：
Acquired Immunodeficiency Syndrome Address Animal Model Animals Archives Area Award Basic Science Biological Biological Assay Cell Culture Techniques Cells Cessation of life Clinical Collaborations Consultations Control Animal Data Data Analyses Databases Development Disease Doctor of Philosophy Electronics Environment Experimental Designs Extramural Activities Faculty Flow Cytometry Foundations Funding Goals HIV HIV/TB Health Human Immunity Immunologics Immunology In Vitro Infection Institution Knowledge Laboratories Lead Leadership Link Methods Microbiology Mission Modeling Mycobacterium Infections Mycobacterium tuberculosis Pathogenesis Primates Research Research Personnel Resources Rodent SIV Series Services Sorting Specimen Surveys Talents Training Translational Research Tuberculosis Universities Vaccination Vaccines Veterinary Medicine assay development biobank co-infection cohort college combat community center high dimensionality human model innovation instrument laboratory equipment member multidisciplinary mycobacterial nonhuman primate novel strategies pandemic disease programs protocol development repository tool transmission process tuberculosis immunity vaccination against tuberculosis vaccine trial

项目摘要

The Basic & Translational Science (Basic Science) Core of the Emory/Georgia TRAC will provide expertise and resources to facilitate TRAC investigator-led studies of mycobacterial pathogenesis, transmission, and host immunity in both human and animal models of Mycobacterium tuberculosis (Mtb) infection. The Basic Science Core will capitalize on a unique set of resources available to the TRAC community, including the Yerkes National Primate Research Center with capacity to conduct Mtb studies in rodents and nonhuman primates, and the University of Georgia Animal Health Research Center with extensive animal BSL3 lab space and capacity to conduct mycobacterial infection and vaccination studies in a variety of large, medium, and small animals. The overall mission of the Basic Science Core is to provide laboratory expertise, training, and resources to catalyze opportunities for innovative multidisciplinary and highly collaborative TB research programs engaging Basic Science Core faculty, early-stage investigators, and established investigators who are new to the TB field. The Core will achieve these goals by providing training, consultation, and services with state-of-the-art laboratory equipment, facilities, and methods, including the newest immunological and microbiological assays and animal Mtb infection models, in addition to providing a quality-controlled central repository of materials for the TRAC community. In Aim 1, consultation in experimental design and laboratory assay approaches will be provided to investigators who are planning basic and translational science studies of Mtb. Specific training areas will include Mtb culture and in vitro infection; Mtb infection of animals; and lab assay training, data interpretation, and protocol development. In Aim 2, the Core will provide support to TRAC investigators to generate preliminary laboratory-based data for internal and external funding applications; conduct laboratory assays and animal Mtb infection and vaccination studies in support of TRAC-series Developmental awards and other funded projects; and support the development of new microbiology and immunology laboratory-based assays. In Aim 3, a biorepository and electronic database will be established for archiving clinical specimens and isolates from human cohorts across a range of Mtb infection and disease states; specimens from Mtb-infected and control animals; and common Mtb laboratory strains for use by TRAC investigators. In summary, the Basic Science Core will provide value-added activities in training, services, and materials to Emory/Georgia TRAC investigators, with the overall goal of supporting TRAC investigators to successfully establish and expand innovative research programs filling critical knowledge gaps in TB pathogenesis, transmission, and immunity to more effectively combat the global TB pandemic.

Emory/Georgia TRAC的基础与转化科学（基础科学）核心将提供专业知识