Transgenic/Behavior Core

MARY/摘要和 转基因小鼠模型对阿尔茨海默病(AD)和其他人类疾病的研究具有重要意义 神经退行性疾病。对AD小鼠模型的认知和行为评估提供了终极 可以评估病理机制和/或生物标记物的表型，并有助于识别 有望成为进一步临床研究的靶点。20个AD小鼠品系的准确性和可用性以及 它们表型的有效性和稳健性对于拟议的行为、药理和 本PO1提案的项目2和项目3中描述的免疫学研究。该计划的总体目标 转基因/行为核心(Core C)是支持独立和协同的动物和行为 这些项目的要求。它的具体目标是：1)建立和维护转基因和突变型AD 小鼠模型系，2)对AD小鼠模型进行全面的行为表型分析，3) 确定药物和免疫干预对特定疾病的影响 认知/行为过程。为了实现这些目标，Core C将利用专门的住房和 纽约大学啮齿动物行为实验室(NYU-RBL)的行为测试设施，以及专门的专业知识 和人员来实施大规模的、全面的行为表型识别电池，包括 “传统”测试和创新的触摸屏范例。酷睿的这些价值功能将提供实验室- 跨多个项目的独立标准化和时间/成本效益，以及帮助最大限度地 AD小鼠模型表型结果的稳健性和临床转译。

SUM M ARY / ABSTRACT Transgenic mouse models have been instrumental to research on Alzheimer’s disease (AD) and other human neurodegenerative disorders. Cognitive and behavioral assessment of AD mouse models provides the ultimate phenotype for which pathological mechanisms and/or biomarkers can be evaluated, and helps identify promising targets for further clinical investigation. The veracity and availability of twenty AD mouse lines and the validity and robustness of their phenotypes are critical to the proposed behavioral, pharmacological and immunological studies described in Projects 2 and 3 of this PO1 proposal. The overall goal of the Transgenic/Behavior Core (Core C) is to support the independent and synergistic animal and behavioral requirements of these Projects. Its specific aims are to 1) establish and maintain transgenic and mutant AD mouse model lines, 2) perform comprehensive behavioral phenotyping of the AD mouse models and 3) determine the impact of pharmacological and immunological interventions on specific cognitive/behavioral processes. To meet these aims, Core C will leverage specialized housing and behavioral testing facilities in the NYU Rodent Behavior Laboratory (NYU-RBL), as well as dedicated expertise and personnel to implement a large-scale, comprehensive behavioral phenotyping battery that includes both “traditional” tests and innovative touchscreen paradigms. These value features of the Core will provide lab- independent standardization and time/cost-efficiency across the multiple Projects, as well as help maximize the robustness and clinical translation of AD mouse model phenotyping results.