Research Coordinating Center to Reduce Disparities in Multiple Chronic Diseases (RCC RD-MCD)

摘要 在预防、治疗和管理多种慢性病方面存在显著差异 交叉性的种族、文化、社会经济和弱势群体的背景线；社区 要有效地缩小这些差距，就需要接触和了解文化知识的多层次办法。 加州大学旧金山分校研究协调中心将利用我们重要的专业知识、经验和 具有社区参与研究、差异研究、项目实施经验 服务不足和弱势群体、数据科学和重大慢性病，以服务和支持 全国研究协调与技术援助中心。该项目的具体目标是： 1)发展NIMHD RD-MCD研究联盟及其监督机制：通过 组织和管理股的召集、安全通信、内部和外部资源 共享、标准化、进度、站点和研究监控以及传播功能，通过508- 合规联合体网站，与计划官员、代表指导委员会、 网络社区咨询委员会，以及独立的数据和安全监测委员会(DSMB)。 2)实施RD-MCD联盟范围内的公共数据元素开发、收集、集成、 利用现有发展良好的国家数据协调和收集进行管理、分析和共享 中心资源和专门知识组成研究协调和数据管理(RCDM)股 为RD-MCD联盟数据提供安全且可访问的数据仓库中心，并提供技术支持- 执行包括PhenX在内的多种数据标准和交叉研究工具 工具包集合(例如，健康的社会决定因素(SDOH))；以及最新的RD-MCD信息、工具、 通过安全的面向调查员和面向社区的网站资源页面提供信息和资源。 3)建立多元慢性病差异(MCD)研究教育发展 网络：由结合科学、网络和技能建设的技能发展股提供便利 跨P50 MCD研究联盟的专业知识，以实施和维护多样化的开发 为学术研究人员、少数群体服务机构、卫生工作者和其他社区提供机会 合伙人。RCC将提供和协调：a)每月网络研讨会，b)年度技能发展 讲习班，c)接触MCD财团和NIH国家研究指导机构的导师 (D)跟踪农村信用合作中心和中心发展活动的影响。 4)促进和监测NIMHD RD-MCD P50研究中充满活力的社区参与研究 联盟成员和社区合作伙伴通过社区参与(CE)股提供 获得服务不足/弱势群体的技术援助(TA)小组，结构性和 为实践共同体和协作科学工作组提供组织支持。

SUMMARY Significant disparities in prevention, treatment, and management of multiple chronic diseases exist along intersecting racial, cultural, socio-economic, and vulnerable population contextual lines; community engagement and culturally informed multilevel approaches are required to effectively reduce these disparities. The UCSF Research Coordinating Center will leverage and pivot our significant expertise, experience, and capacity in community-engaged research, disparities research, program implementation experience with underserved and vulnerable populations, data science, and major chronic diseases to serve and support a nationwide research coordinating and technical assistance center. The Specific Aims of the project are to: 1) Develop the NIMHD RD-MCD Research Consortium and its Oversight Mechanisms: through the Organizational and Management Unit’s convening, secure communication, internal and external resource sharing, standardization, progress, site, and study monitoring, and dissemination functions via a 508- compliant consortium website in cooperation with program officials, representative Steering Committee, networked Community Advisory Boards, and an independent Data and Safety Monitoring Board (DSMB). 2) Implement RD-MCD Consortium-wide Common Data Element Development, Collection, Integration, Curation, Analysis, and Sharing using existing well-developed national data coordinating and collection center resources and expertise forming a Research Coordination & Data Management (RCDM) Unit providing a secure and accessible data warehouse hub for RD-MCD Consortium data, and technical assist- ance and guidance on: implementing multiple data standards and cross-study instruments including PhenX toolkit collections (e.g. Social Determinants of Health (SDOH)); and up-to-date RD-MCD information, tools, and resources via secured investigator-facing and community-facing website resource pages. 3) Establish a Multiple Chronic Diseases Disparities (MCD) Research Educational Development Network: facilitated by the Skills Development Unit combining scientific, networking, and skills building expertise across the P50 MCD research consortium to implement and maintain diverse development opportunities for academic researchers, minority-serving institutions, health workers, and other community partners. The RCC will deliver and coordinate: a) monthly webinars, b) yearly skills development workshops, c) access to mentors across the MCD consortium and the NIH National Research Mentoring Network, and d) track the impact of the RCC and Center’s development activities. 4) Facilitate and Monitor Vibrant Community-Engaged Research among NIMHD RD-MCD P50 Research Consortium members and community partners through a Community Engagement (CE) Unit providing access to underserved/vulnerable population-specific Technical Assistance (TA) teams, structural and organizational support for a Community of Practice, and collaborative Scientific Working Groups.