Prescription After CesareanTrial - (PACT) MFMU Supplement
Prescription After CesareanTrial - (PACT) MFMU Supplement
批准号:
10434255
负责人:
Rebecca Gersnoviez Clifton
金额:
$55.0万
依托单位国家:
美国
项目类别:
财政年份:
2021
资助国家:
美国
项目状态:
已结题
起止时间:
2021-07-01 至 2022-03-31
关键词:
Absence of pain sensationAcetaminophenAcuteAnalgesicsBirthCaringCesarean sectionCessation of lifeChronicClient satisfactionClinicalDataDependenceDevelopmentFaceHospitalizationHospitalsIbuprofenIndividualIngestionInstitutionLeadLifeMaternal MortalityMaternal-Fetal Medicine Units NetworkMorphineNational Institute of Child Health and Human DevelopmentNon-Steroidal Anti-Inflammatory AgentsOperative Surgical ProceduresOpioidOpioid AnalgesicsOverdoseOxycodonePainPain ThresholdPain intensityPain interferencePain managementPatientsPlayPostoperative PainPostoperative PeriodPregnancy RatePrescription opioid overdoseProcessProtocols documentationProviderRandomizedRegimenReportingRoleSurgeonTabletsTestingUnited StatesWomanadverse maternal outcomesimpressionimprovedimproved outcomeinfant outcomemilligramnon-opioid analgesicnonmedical useopioid epidemicopioid usepain scorepandemic diseasepostcesarean sectionpregnancy associated deathprescription opioidrandomized trialsatisfactionshared decision makingstandard of care
中文摘要
项目总结
英文摘要
PROJECT SUMMARY
Cesarean delivery is the most commonly performed major surgical procedure in the United States. Systemic
opioids have been universally used for post-cesarean analgesia management, with the number of tablets
prescribed varying significantly between providers and institutions. Pain thresholds and analgesic requirements
vary between patients, and studies suggest that most women are given prescriptions for at least 10 more
tablets at discharge than needed. The consequence of over-prescribing opioids for 1.2 million cesareans
annually is 12.5 million unused tablets. These unused tablets often go unguarded, and undisposed, providing
an important reservoir of opioids that may be misused, diverted or accidentally ingested, contributing to the
opioid crisis. The one-size-fits-all approach to pain management is clearly suboptimal. Some women may not
even need opioids: one small study reported that pain scores were higher among women who were prescribed
opioids than those who were prescribed ibuprofen and acetaminophen. While recent studies have evaluated
opioid prescribing practices, there are limited data on the effect of using an individualized opioid prescription
protocol following a cesarean delivery.
The Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal Fetal
Medicine Units (MFMU) Network proposes a non-inferiority multi-center unblinded randomized trial of 5,500
women undergoing a cesarean delivery who are randomized before discharge to either an individualized opioid
prescription protocol (IOPP) that includes shared decision-making or to a fixed opioid prescription of 20 tablets
of oxycodone 5mg which approximates current standard of care at the participating institutions. The primary
aim is to evaluate whether IOPP with shared decision-making is not inferior to a fixed opioid prescription of 20
tablets of oxycodone 5mg in pain management defined as the presence/absence of moderate to severe pain at
1 week after discharge. Secondary aims will evaluate whether IOPP with shared decision making 1)
decreases an opioid refill prescription, 2) decreases the total amount of opioid tablets prescribed and the total
morphine milligram equivalents used, 3) has equivalent pain intensity and interference, and satisfactions
scores, and 4) reduces adverse maternal and infant outcomes.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
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批准号:10455579
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项目类别:
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资助金额:$0.0万
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财政年份:2018
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负责人:Rebecca Gersnoviez Clifton
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依托单位:
2/2: A Randomized Controlled Trial of Pravastatin for the Prevention of Preeclampsia in High Risk Women
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批准号:10022162
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项目类别:
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资助金额:$217.54万
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财政年份:2018
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负责人:Rebecca Gersnoviez Clifton
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依托单位:
2/2: A Randomized Controlled Trial of Pravastatin for the Prevention of Preeclampsia in High Risk Women
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批准号:10242076
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项目类别:
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资助金额:$196.96万
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财政年份:2018
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负责人:Rebecca Gersnoviez Clifton
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依托单位:
2/2: A Randomized Controlled Trial of Pravastatin for the Prevention of Preeclampsia in High Risk Women
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批准号:9768536
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项目类别:
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资助金额:$216.61万
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财政年份:2018
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负责人:Rebecca Gersnoviez Clifton
-
依托单位:
2/2: A Randomized Controlled Trial of Pravastatin for the Prevention of Preeclampsia in High Risk Women
-
批准号:10705625
-
项目类别:
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资助金额:$0.0万
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财政年份:2018
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负责人:Rebecca Gersnoviez Clifton
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依托单位:
RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium
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批准号:8332527
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项目类别:
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资助金额:$2.51万
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财政年份:2011
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负责人:Rebecca Gersnoviez Clifton
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依托单位:
RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium
-
批准号:8546001
-
项目类别:
-
资助金额:$1.91万
-
财政年份:2011
-
负责人:Rebecca Gersnoviez Clifton
-
依托单位:
RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium
-
批准号:8335570
-
项目类别:
-
资助金额:$10.0万
-
财政年份:2011
-
负责人:Rebecca Gersnoviez Clifton
-
依托单位:
RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium
-
批准号:8334001
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项目类别:
-
资助金额:$53.74万
-
财政年份:2011
-
负责人:Rebecca Gersnoviez Clifton
-
依托单位:
RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium
-
批准号:8919157
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项目类别:
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资助金额:$21.72万
-
财政年份:2011
-
负责人:Rebecca Gersnoviez Clifton
-
依托单位:
RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium
-
批准号:8722235
-
项目类别:
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资助金额:$32.51万
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财政年份:2011
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负责人:Rebecca Gersnoviez Clifton
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依托单位:
RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium
-
批准号:8919072
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项目类别:
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资助金额:$20.65万
-
财政年份:2011
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负责人:Rebecca Gersnoviez Clifton
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依托单位:
RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium
-
批准号:8541850
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项目类别:
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资助金额:$44.32万
-
财政年份:2011
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负责人:Rebecca Gersnoviez Clifton
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依托单位:
RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium
-
批准号:9101199
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项目类别:
-
资助金额:$25.03万
-
财政年份:2011
-
负责人:Rebecca Gersnoviez Clifton
-
依托单位:
RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium
-
批准号:8537719
-
项目类别:
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资助金额:$22.93万
-
财政年份:2011
-
负责人:Rebecca Gersnoviez Clifton
-
依托单位:
RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium
-
批准号:8521725
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项目类别:
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资助金额:$4.84万
-
财政年份:2011
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负责人:Rebecca Gersnoviez Clifton
-
依托单位:
RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium
-
批准号:8925859
-
项目类别:
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资助金额:$51.21万
-
财政年份:2011
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负责人:Rebecca Gersnoviez Clifton
-
依托单位:
RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium
-
批准号:8732626
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项目类别:
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资助金额:$41.83万
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财政年份:2011
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负责人:Rebecca Gersnoviez Clifton
-
依托单位:
RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium
-
批准号:9319124
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项目类别:
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资助金额:$27.15万
-
财政年份:2011
-
负责人:Rebecca Gersnoviez Clifton
-
依托单位:
RCU for Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium
-
批准号:8248471
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项目类别:
-
资助金额:$52.06万
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财政年份:2011
-
负责人:Rebecca Gersnoviez Clifton
-
依托单位:
国内基金
海外基金
SirT1在Acetaminophen诱发的药物性肝损伤中的作用及机制
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批准号:81100281
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项目类别:青年科学基金项目
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资助金额:24.0万元
-
批准年份:2011
-
负责人:黄卫锋
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依托单位: