Estrogenic modulation of neural circuits that control temperature

项目摘要 促进健康相关研究多样性的研究补充“雌激素调节 控制温度的神经电路”将支持博士研究培训和职业生涯 Stephanie Correa博士实验室的候选人的发展。雌激素停药， 更年期与一系列代谢、血管和神经内分泌变化有关， 健康和生活质量。与更年期有关的最具体的症状是血管扩张 症状，包括潮热和盗汗。一般认为血管扩张症状是 由绝经过渡期雌激素水平波动引起。然而，目前还不清楚如何 这些变化影响大脑的温度调节。我们发表的研究结果确定了一个 内侧视前区表达雌激素受体α（ER α）的神经元的温度调节作用 (MPO)下丘脑我们假设MPO中的ER α信号调节了 体温调节神经回路候选人的论文研究将决定 雌激素反应和雌激素信号在体温调节ER α +中的转录作用 神经元补充培训计划重新安排了《公约》所要求的培训活动的顺序， 博士课程，并补充这些活动与正式的课程，以适应职业目标的 候选人。这些量身定制的干预措施将使候选人能够在最高级别竞争， 最终在一家顶级研究机构成为一名老龄化研究人员。

PROJECT SUMMARY The Research Supplement to Promote Diversity in Health-Related Research to “Estrogenic Modulation of Neural Circuits that Control Temperature” will support the doctoral research training and career development of the candidate in the laboratory of Dr. Stephanie Correa. Estrogen withdrawal at menopause is associated with a suite of metabolic, vascular, and neuroendocrine changes that impact health and quality of life. The most specific symptoms associated with menopause are vasomotor symptoms, which include hot flashes and night sweats. It is thought that vasomotor symptoms are caused by fluctuating estrogen levels at the time of the menopausal transition. However, it is unclear how these changes affect temperature regulation in the brain. Our published findings identify a thermoregulatory role for neurons that express estrogen receptor alpha (ERa) in the medial preoptic area (MPO) of the hypothalamus. We hypothesize that ERa signaling in the MPO modulates the activity of thermoregulatory neural circuits. The candidate’s dissertation research will determine the dynamics of estrogen responses and the transcriptional effects of estrogen signaling in thermoregulatory ERa+ neurons. The complementary training plan restructures the sequence of training activities required by the doctoral program and supplements these activities with formal coursework to suit the career objectives of the candidate. These tailored interventions will position the candidate to compete at the highest level and ultimately establish a career as an aging researcher at a top research institution.