Estrogenic modulation of neural circuits that control temperature

控制温度的神经回路的雌激素调节

• 批准号: 10429750
• 负责人: Stephanie Correa
• 金额: $ 6.36万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10429750
• 关键词: Affect; Aging; Award; Blood Vessels; Brain; Estrogen Receptor alpha; Estrogens; Genetic Transcription; Health; Hot flushes; Human; Hypothalamic structure; Institution; Intervention; Laboratories; Lead; Medial; Menopause; Metabolic; Modeling; Mus; Neurons; Neurosecretory Systems; Night Sweating; Perimenopause; Positioning Attribute; Preoptic Areas; Publishing; Quality of life; Regulation; Research; Research Personnel; Research Project Summaries; Research Training; Role; Signal Transduction; Symptoms; Temperature; Time; Training; Training Activity; Vasomotor; Withdrawal; associated symptom; career; career development; estrogenic; neural circuit; programs; response

PROJECT SUMMARY The Research Supplement to Promote Diversity in Health-Related Research to “Estrogenic Modulation of Neural Circuits that Control Temperature” will support the doctoral research training and career development of the candidate in the laboratory of Dr. Stephanie Correa. Estrogen withdrawal at menopause is associated with a suite of metabolic, vascular, and neuroendocrine changes that impact health and quality of life. The most specific symptoms associated with menopause are vasomotor symptoms, which include hot flashes and night sweats. It is thought that vasomotor symptoms are caused by fluctuating estrogen levels at the time of the menopausal transition. However, it is unclear how these changes affect temperature regulation in the brain. Our published findings identify a thermoregulatory role for neurons that express estrogen receptor alpha (ERa) in the medial preoptic area (MPO) of the hypothalamus. We hypothesize that ERa signaling in the MPO modulates the activity of thermoregulatory neural circuits. The candidate’s dissertation research will determine the dynamics of estrogen responses and the transcriptional effects of estrogen signaling in thermoregulatory ERa+ neurons. The complementary training plan restructures the sequence of training activities required by the doctoral program and supplements these activities with formal coursework to suit the career objectives of the candidate. These tailored interventions will position the candidate to compete at the highest level and ultimately establish a career as an aging researcher at a top research institution.

项目总结 促进健康相关研究多样性的研究副刊《雌激素调节》 “控制温度的神经电路”将支持博士研究培训和职业生涯 斯蒂芬妮·科雷亚博士实验室候选人的发展。雌激素停用时间： 更年期与一系列代谢、血管和神经内分泌变化有关，这些变化影响 健康和生活质量。与更年期相关的最特殊的症状是血管舒缩 症状，包括潮热和盗汗。据认为，血管舒缩症状是 由绝经过渡时雌激素水平波动引起的。然而，目前还不清楚是如何 这些变化会影响大脑中的温度调节。我们发表的研究结果表明， 视前内侧区雌激素受体α(ERA)表达神经元的体温调节作用 下丘脑(MPO)。我们假设，MPO中的ERA信号调节了 体温调节神经回路。候选人的论文研究将决定 体温调节时代的雌激素反应及雌激素信号的转录效应 神经元。补充性培训计划调整了培训活动的顺序， 博士课程，并用正规的课程来补充这些活动，以适应 候选人。这些量身定做的干预措施将使候选人能够在最高水平和 最终在一家顶级研究机构建立起老年研究员的职业生涯。