Tri-Institutional TRAC Basic Science Core

摘要 控制结核病大流行的努力有赖于基本的和双向的密切结合 临床研究，因为结核病是人类独有的疾病。考古DNA证据进一步表明 人类构成结核分枝杆菌(Mtb)唯一已知的宿主和宿主，使人们了解到 结核病的基础生物学依赖于在多样化和专业化的学科网络和 技术。由Sabine Ehrt博士和Mike Glickman博士领导的基础科学核心试图满足这些要求 通过向结核病研究人员(NI/N2TB)提供新的和新的技术专长和资源来满足需求 追求创新的多学科调查路线，同时促进他们进入 结核病研究领域。为此，该核心将提供以下机构的结构化指导：高级结核病调查人员 威尔·康奈尔，纪念斯隆·凯特琳和洛克菲勒大学在七个领域的基础科学与 结核病研究(“OMICS”技术、基因筛查技术、结核病小鼠模型、分枝杆菌 遗传学、分子生物学和生物化学、人类遗传学和免疫学、药物开发和 化学、生物信息学和数据分析)；以及来自这些学院实验室的技术专家 在这七个方面提供实践培训。这些高级调查人员还将促进 这些新的和新的结核病研究人员在各自的领域有预先存在的合作者。这个 聚集的教员是细菌遗传学、动物模型、免疫学、 代谢组学和基因筛选，并在指导和跨学科方面有广泛的记录 协作。 基础科学核心将与发展核心密切合作，并提供2 训练路径：“训练走向独立之路”与“专业技术训练” 路径“。前者的目标是帮助NIS获得一个独立的教职员工职位和他们的第一个R01和 将包括指导、职业发展、技术专家和获得基础科学的机会 资源(动物设施、转基因结核杆菌文库、质谱学等)。后者的目标是 途径是为NIS、N2TB和其他调查人员提供有针对性的支持，并让技术专家参与 获得专门技能和/或技术转让以及获得基础科学核心资源。 综合起来，这些活动将使基础科学核心部门能够实现TRAC的总体目标 计划：1)增加NIH资助的从事基础科学和翻译工作的研究人员的数量 结核病研究，2促进多学科的结核病研究。

ABSTRACT Efforts to control the tuberculosis (TB) pandemic depend on a close and bidirectional integration of basic and clinical research because TB is a human-only disease. Archaeological DNA evidence further indicates that humans constitute Mycobacterium tuberculosis’ (Mtb) only known host and reservoir, making knowledge of the fundamental biology of TB dependent on training in a both a diverse and specialized network of disciplines and technologies. The Basic Science Core, led by Drs. Sabine Ehrt and Mike Glickman, seeks to meet these needs by providing new, and new to TB, investigators (NI/N2TB) access to technical expertise and resources to pursue innovative multidisciplinary lines of investigation while simultaneously facilitating their entry into the field of TB research. To do so, this core will provide structured mentorship from: senior TB investigators at Weill Cornell, Memorial Sloan Kettering and Rockefeller University in seven areas of basic science relevant to TB research (“OMICS” technologies, genetic screening technologies, TB mouse models, mycobacterial genetics, molecular biology and biochemistry, human genetics and immunology, drug development and chemistry, and bioinformatics and data analysis); and technical experts from the labs of these faculty to provide hands-on training in these seven areas. These senior investigators will also facilitate the networking of these new, and new to TB, investigators with pre-existing collaborators in their respective fields. The assembled faculty are leaders in the mycobacterial subfields of bacterial genetics, animal models, immunology, metabolomics, and genetic screening and have an extensive track record of mentoring and interdisciplinary collaboration. The Basic Science Core will operate in close collaboration with the Developmental Core and offer 2 funded training pathways: the “Training to Independence Pathway” and the “Specialized Technology Training Pathway”. The goal of the former is to help NIs secure an independent faculty position and their first R01 and will involve a package of mentorship, career development, technical experts and access to basic science resources (animal facilities, genetically modified Mtb libraries, mass spectrometry, etc.). The goal of the latter pathway is to provide NIs, N2TB, and other investigators with focused support and involve technical experts for specialized skills acquisition and/or technology transfer and access to basic science core resources. Together, these activities will enable the Basic Science Core to meet the overarching goals of this TRAC program to: 1) increase the number of NIH funded investigators conducting basic science and translational research in TB, and 2 foster multidisciplinary TB research.