Tri-Institutional TRAC Basic Science Core

三机构 TRAC 基础科学核心

• 批准号: 10430741
• 负责人: SABINE EHRT
• 金额: $ 22.33万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10430741
• 关键词: Animal Model; Archaeology; Area; Basic Science; Biochemistry; Bioinformatics; Biology; Chemistry; Clinical Research; Collaborations; Core Facility; DNA; Data Analyses; Development; Discipline; Disease; Equipment; Faculty; Faculty Recruitment; Fostering; Funding; Genetic; Genetic Screening; Goals; Human; Human Genetics; Immunology; Investigation; Knowledge; Leadership; Libraries; Mass Spectrum Analysis; Mentors; Mentorship; Methodology; Modeling; Molecular Biology; Mycobacterium tuberculosis; National Institute of Allergy and Infectious Disease; Pathway interactions; Policies; Positioning Attribute; Procedures; Proteomics; Recovery; Research; Research Personnel; Resources; Role; Science; Secure; Senior Scientist; Services; Structure; Supervision; Technical Expertise; Technology; Technology Transfer; Training; Translational Research; Tuberculosis; United States National Institutes of Health; Universities; animal facility; bacterial genetics; career development; cost; drug development; innovation; innovative technologies; interdisciplinary collaboration; lipidomics; metabolomics; mouse model; multidisciplinary; mycobacterial; pandemic disease; programs; skill acquisition; statistics; technology training; transcriptomics

ABSTRACT Efforts to control the tuberculosis (TB) pandemic depend on a close and bidirectional integration of basic and clinical research because TB is a human-only disease. Archaeological DNA evidence further indicates that humans constitute Mycobacterium tuberculosis’ (Mtb) only known host and reservoir, making knowledge of the fundamental biology of TB dependent on training in a both a diverse and specialized network of disciplines and technologies. The Basic Science Core, led by Drs. Sabine Ehrt and Mike Glickman, seeks to meet these needs by providing new, and new to TB, investigators (NI/N2TB) access to technical expertise and resources to pursue innovative multidisciplinary lines of investigation while simultaneously facilitating their entry into the field of TB research. To do so, this core will provide structured mentorship from: senior TB investigators at Weill Cornell, Memorial Sloan Kettering and Rockefeller University in seven areas of basic science relevant to TB research (“OMICS” technologies, genetic screening technologies, TB mouse models, mycobacterial genetics, molecular biology and biochemistry, human genetics and immunology, drug development and chemistry, and bioinformatics and data analysis); and technical experts from the labs of these faculty to provide hands-on training in these seven areas. These senior investigators will also facilitate the networking of these new, and new to TB, investigators with pre-existing collaborators in their respective fields. The assembled faculty are leaders in the mycobacterial subfields of bacterial genetics, animal models, immunology, metabolomics, and genetic screening and have an extensive track record of mentoring and interdisciplinary collaboration. The Basic Science Core will operate in close collaboration with the Developmental Core and offer 2 funded training pathways: the “Training to Independence Pathway” and the “Specialized Technology Training Pathway”. The goal of the former is to help NIs secure an independent faculty position and their first R01 and will involve a package of mentorship, career development, technical experts and access to basic science resources (animal facilities, genetically modified Mtb libraries, mass spectrometry, etc.). The goal of the latter pathway is to provide NIs, N2TB, and other investigators with focused support and involve technical experts for specialized skills acquisition and/or technology transfer and access to basic science core resources. Together, these activities will enable the Basic Science Core to meet the overarching goals of this TRAC program to: 1) increase the number of NIH funded investigators conducting basic science and translational research in TB, and 2 foster multidisciplinary TB research.

抽象的 控制结核病（TB）大流行的努力取决于基本和 临床研究是因为结核病是一种仅由人为疾病。考古DNA证据进一步表明 人类构成结核分枝杆菌（MTB）仅是已知的宿主和水库，因此了解了 结核病的基本生物学取决于潜水员和专业的学科网络和专业网络的培训和 技术。由Drs领导的基础科学核心。 Sabine Ehrt和Mike Glickman试图见到这些 通过提供新的和新的TB的需求，调查人员（NI/N2TB）访问技术专长和资源 购买创新的多学科投资线，同时支持他们进入 结核病研究领域。为此，此核心将提供结构化的概念化： 威尔·康奈尔（Weill Cornell 结核病研究（“ OMICS”技术，遗传筛查技术，结核病小鼠模型，分枝杆菌 遗传学，分子生物学和生物化学，人类遗传学和免疫学，药物发展和 化学，生物信息学和数据分析）；这些教师实验室的技术专家 在这七个领域提供动手培训。这些高级调查人员还将促进 这些新的，新的是结核病，研究人员在各自的领域拥有与众不同的合作者。这 组装教师是细菌遗传学，动物模型，免疫学， 代谢组学和基因筛查，并具有广泛的心理和跨学科记录 合作。 基础科学核心将与发展核心密切合作，并提供2个资助 训练途径：“独立训练”和“专业技术培训 途径”。前者的目标是帮助NIS确保独立的教师职位和他们的第一个R01和 将涉及一系列心态，职业发展，技术专家和基础科学的访问 资源（动物设施，一般修改的MTB库，质谱等）。后来的目标 Pathway将为NIS，N2TB和其他调查人员提供专注的支持，并涉及技术专家 专业技能获取和/或技术转移以及访问基础科学核心资源。 这些活动将共同使基本科学核心能够实现此序列的总体目标 计划至：1）增加进行基础科学和翻译的NIH资助的研究人员的数量 结核病研究和2个促进多学科结核病研究。