Tri-Institutional TRAC Basic Science Core

摘要 控制结核病大流行的努力取决于基础和预防措施的密切和双向整合。 临床研究，因为结核病是一种人类特有的疾病。考古DNA证据进一步表明 人类是结核分枝杆菌 (Mtb) 唯一已知的宿主和储存库，这使得人们对结核分枝杆菌的了解越来越多。 结核病的基础生物学依赖于多样化和专业化的学科网络的培训 技术。基础科学核心，由博士领导。 Sabine Ehrt 和 Mike Glickman 试图满足这些要求 通过为新的结核病研究人员（NI/N2TB）提供技术专业知识和资源来满足需求 追求创新的多学科调查路线，同时促进他们进入 结核病研究领域。为此，该核心将提供来自以下机构的结构化指导： 高级结核病调查员 威尔·康奈尔大学、纪念斯隆·凯特琳大学和洛克菲勒大学在七个相关基础科学领域 结核病研究（“组学”技术、基因筛查技术、结核病小鼠模型、分枝杆菌 遗传学、分子生物学和生物化学、人类遗传学和免疫学、药物开发和 化学、生物信息学和数据分析）；以及这些学院实验室的技术专家 提供这七个领域的实践培训。这些高级调查员还将促进网络 这些新的、结核病领域的新研究人员与各自领域已有的合作者。的 聚集的教师是细菌遗传学、动物模型、免疫学、分枝杆菌子领域的领导者， 代谢组学和基因筛查，并在指导和跨学科方面拥有广泛的记录 合作。 基础科学核心将与发展核心密切合作，并提供 2 项资助 培训途径：“独立培训途径”和“专业技术培训” 途径”。前者的目标是帮助 NI 获得独立的教职职位以及他们的第一个 R01 和 将涉及一揽子指导、职业发展、技术专家和基础科学知识 资源（动物设施、转基因结核菌库、质谱等）。后者的目标 途径是为 NI、N2TB 和其他调查人员提供重点支持，并让技术专家参与其中 专业技能获取和/或技术转让以及获得基础科学核心资源。 这些活动共同将使基础科学核心能够实现 TRAC 的总体目标 计划：1）增加 NIH 资助的从事基础科学和转化研究的研究人员数量 结核病研究，2 促进多学科结核病研究。

ABSTRACT Efforts to control the tuberculosis (TB) pandemic depend on a close and bidirectional integration of basic and clinical research because TB is a human-only disease. Archaeological DNA evidence further indicates that humans constitute Mycobacterium tuberculosis’ (Mtb) only known host and reservoir, making knowledge of the fundamental biology of TB dependent on training in a both a diverse and specialized network of disciplines and technologies. The Basic Science Core, led by Drs. Sabine Ehrt and Mike Glickman, seeks to meet these needs by providing new, and new to TB, investigators (NI/N2TB) access to technical expertise and resources to pursue innovative multidisciplinary lines of investigation while simultaneously facilitating their entry into the field of TB research. To do so, this core will provide structured mentorship from: senior TB investigators at Weill Cornell, Memorial Sloan Kettering and Rockefeller University in seven areas of basic science relevant to TB research (“OMICS” technologies, genetic screening technologies, TB mouse models, mycobacterial genetics, molecular biology and biochemistry, human genetics and immunology, drug development and chemistry, and bioinformatics and data analysis); and technical experts from the labs of these faculty to provide hands-on training in these seven areas. These senior investigators will also facilitate the networking of these new, and new to TB, investigators with pre-existing collaborators in their respective fields. The assembled faculty are leaders in the mycobacterial subfields of bacterial genetics, animal models, immunology, metabolomics, and genetic screening and have an extensive track record of mentoring and interdisciplinary collaboration. The Basic Science Core will operate in close collaboration with the Developmental Core and offer 2 funded training pathways: the “Training to Independence Pathway” and the “Specialized Technology Training Pathway”. The goal of the former is to help NIs secure an independent faculty position and their first R01 and will involve a package of mentorship, career development, technical experts and access to basic science resources (animal facilities, genetically modified Mtb libraries, mass spectrometry, etc.). The goal of the latter pathway is to provide NIs, N2TB, and other investigators with focused support and involve technical experts for specialized skills acquisition and/or technology transfer and access to basic science core resources. Together, these activities will enable the Basic Science Core to meet the overarching goals of this TRAC program to: 1) increase the number of NIH funded investigators conducting basic science and translational research in TB, and 2 foster multidisciplinary TB research.