Tri-Institutional TRAC Basic Science Core

摘要 控制结核病大流行的努力取决于基本和基本医疗服务的密切和双向结合。 临床研究，因为结核病是一种人类独有的疾病。考古DNA证据进一步表明， 人类是结核分枝杆菌（Mtb）唯一已知的宿主和宿主， 结核病的基础生物学依赖于在多样化和专业化的学科网络中进行培训， 技术.由Sabine Ehrt和Mike Glickman博士领导的基础科学核心旨在满足这些需求。 通过为新的和新的结核病研究者（NI/N2 TB）提供技术专长和资源， 寻求创新的多学科调查路线，同时促进他们进入 结核病研究领域。为此，该核心将提供结构化的指导，来自： 威尔康奈尔大学，纪念斯隆凯特林和洛克菲勒大学在七个领域的基础科学有关， 结核病研究（“OMICS”技术、遗传筛选技术、结核病小鼠模型、分枝杆菌 遗传学、分子生物学和生物化学、人类遗传学和免疫学、药物开发和 化学、生物信息学和数据分析）;以及来自这些学院实验室的技术专家， 在这七个方面提供实践培训。这些高级调查员还将促进 这些新的和新的结核病研究人员与各自领域的现有合作者。的 聚集的教师是细菌遗传学，动物模型，免疫学， 代谢组学和遗传筛查，并有广泛的指导和跨学科的跟踪记录 协作 基础科学核心将与发展核心密切合作， 培训途径：“独立培训途径”和“专业技术培训途径 途径”。前者的目标是帮助国家机构获得一个独立的教师职位和他们的第一个R 01， 将包括一系列的指导、职业发展、技术专家和基础科学知识 资源（动物设施、转基因结核分枝杆菌文库、质谱法等）。后者的目标 途径是为NIs，N2 TB和其他研究人员提供重点支持，并让技术专家参与， 获得专门技能和/或技术转让以及获得基础科学核心资源。 这些活动将使基础科学核心项目能够实现本核心预算资源调拨目标的总体目标 计划：1）增加NIH资助的研究人员进行基础科学和翻译的数量 结核病研究，2促进多学科结核病研究。

ABSTRACT Efforts to control the tuberculosis (TB) pandemic depend on a close and bidirectional integration of basic and clinical research because TB is a human-only disease. Archaeological DNA evidence further indicates that humans constitute Mycobacterium tuberculosis’ (Mtb) only known host and reservoir, making knowledge of the fundamental biology of TB dependent on training in a both a diverse and specialized network of disciplines and technologies. The Basic Science Core, led by Drs. Sabine Ehrt and Mike Glickman, seeks to meet these needs by providing new, and new to TB, investigators (NI/N2TB) access to technical expertise and resources to pursue innovative multidisciplinary lines of investigation while simultaneously facilitating their entry into the field of TB research. To do so, this core will provide structured mentorship from: senior TB investigators at Weill Cornell, Memorial Sloan Kettering and Rockefeller University in seven areas of basic science relevant to TB research (“OMICS” technologies, genetic screening technologies, TB mouse models, mycobacterial genetics, molecular biology and biochemistry, human genetics and immunology, drug development and chemistry, and bioinformatics and data analysis); and technical experts from the labs of these faculty to provide hands-on training in these seven areas. These senior investigators will also facilitate the networking of these new, and new to TB, investigators with pre-existing collaborators in their respective fields. The assembled faculty are leaders in the mycobacterial subfields of bacterial genetics, animal models, immunology, metabolomics, and genetic screening and have an extensive track record of mentoring and interdisciplinary collaboration. The Basic Science Core will operate in close collaboration with the Developmental Core and offer 2 funded training pathways: the “Training to Independence Pathway” and the “Specialized Technology Training Pathway”. The goal of the former is to help NIs secure an independent faculty position and their first R01 and will involve a package of mentorship, career development, technical experts and access to basic science resources (animal facilities, genetically modified Mtb libraries, mass spectrometry, etc.). The goal of the latter pathway is to provide NIs, N2TB, and other investigators with focused support and involve technical experts for specialized skills acquisition and/or technology transfer and access to basic science core resources. Together, these activities will enable the Basic Science Core to meet the overarching goals of this TRAC program to: 1) increase the number of NIH funded investigators conducting basic science and translational research in TB, and 2 foster multidisciplinary TB research.