Tampa Bay Life Sciences Computing Commons (TBLSCC)

项目摘要/摘要 为坦帕湾生命科学计算共用(TBLSCC)申请资金，以更新过时的 设备和扩展现有硬件(核心净增加84%)。TBLSCC将充当催化剂，以 巩固基于生命科学的计算能力，使现有设施扩大四倍。这个 TBLSCC将满足当前的需求，支持最近由NIH资助的量化科学的增长，利用 莫菲特癌症中心(MCC)和南方大学计算研究人员的共享专业知识 佛罗里达州(美国联邦)，并实现以前不可能实现的跨机构合作。这份提案包括23项 坦帕湾地区的生命科学研究小组，有超过15个NIH资助的主要或次要研究 代表美国国立卫生研究院每年1亿美元资金的用户。这项计算的科学用例 平台包括癌症、糖尿病、传染病、基因组学、放射组学、人工智能和建模 研究。总体而言，85个生命科学研究小组将直接受益于新系统。 MCC运营着一个82节点、1120核的高性能计算(HPC)集群。当前的硬件和 软件环境正在寿终正寝，减缓了MCC的研究。同样，美国联邦健康信息学研究所(HII) 在生命周期结束时使用80个节点、1388个核心群集。美国联邦最近开发了77节点/1668核心/16TB受限 研究(符合HIPAA)生命科学集群(RRA)，以补充其435节点/9088核心/55 TB 通用集群。RRA包括符合HIPAA的存储以及以下各项的策略和程序 管理基因组学和医学成像研究的访问。我们寻求资金购买86个节点(6016 核心)。我们将利用现有的RRA基础架构来创建TBLSCC，这是一个163节点/7684核心群集 适用于MCC/USF用户，可适应计算密集型研究中20%的年增长率。这 资源将支持跨机构协作，支持开放科学，并管理不断增长的需求 关于利用共享的MCC/USF研究需求的计算资源、USF研究计算专业知识、 和MCC共享服务计算专业知识。 MCC和USF位于同一地点，每年有近3亿美元的NIH资金。MCC是唯一一家总部位于佛罗里达州的 NCI指定的具有创新研究的综合癌症中心，包括集成数学 肿瘤学和机器学习。美国联邦将高影响力的全球研究作为卓越的研究 在产生新专利方面，他在美国公立研究型大学中排名第八。这个 TBLSCC将支持这一充满活力的生命科学研究社区，并为专注于健康的 创新。

Project Summary/Abstract Funds are requested for the Tampa Bay Life Sciences Computing Commons (TBLSCC), to refresh outdated equipment and expand existing hardware (84% net increase in cores). The TBLSCC will serve as a catalyst to consolidate life-sciences based compute capacity, resulting in fourfold expansion of the existing facility. The TBLSCC will meet current demands, support recent NIH-funded growth in quantitative sciences, leverage the shared expertise of computational researchers at Moffitt Cancer Center (MCC) and the University of South Florida (USF), and enable cross-institutional collaboration not previously possible. This proposal includes 23 life sciences research groups in the Tampa Bay area, with more than 15 NIH funded research Major or Minor Users representing over $100 million in annual NIH funding. The scientific use cases for this computational platform include cancer, diabetes, infectious disease, genomics, radiomics, artificial intelligence, and modelling research. Overall, 85 life sciences research groups would directly benefit from the new system. MCC operates an 82-node, 1120-core high-performance computing (HPC) cluster. The current hardware and software environment is end-of-life, slowing MCC research. Likewise, the USF Health Informatics Institute (HII) uses an 80 node, 1388 core cluster at end of life. USF recently developed a 77 node/1668 core/16TB restricted research (HIPAA-compliant) life sciences cluster (RRA) to complement their 435 node/9088 core/55 TB general-purpose cluster. RRA includes HIPAA-compliant storage, as well as policies and procedures for managing access for genomics and medical imaging research. We seek funds to purchase 86 nodes (6016 cores). We will leverage the existing RRA infrastructure to create the TBLSCC, a 163 node/7684 core cluster available for MCC/USF users that can accommodate 20% annual growth in computing intensive research. This resource will support cross-institutional collaboration, enable open science, and manage increased demands on computational resources leveraging shared MCC/USF research needs, USF research computing expertise, and MCC shared services computational expertise. MCC and USF are co-located with almost $300 million per year of NIH funding. MCC is the only Florida-based NCI-designated Comprehensive Cancer Center with innovative research, including Integrated Mathematical Oncology and Machine Learning. USF performs high-impact global research as a Preeminent Research University in Florida and is eighth among American public research universities in generating new patents. The TBLSCC will support this vibrant life science research community and provide a platform for health-focused innovations.