Tampa Bay Life Sciences Computing Commons (TBLSCC)

项目总结/摘要 请求为坦帕湾生命科学计算共享区（TBLSCC）提供资金， 设备和扩展现有硬件（核心净增84%）。TBLSCC将作为催化剂， 巩固基于生命科学的计算能力，使现有设施扩大四倍。的 TBLSCC将满足当前的需求，支持最近NIH资助的定量科学增长，利用 莫菲特癌症中心（MCC）和南方大学计算研究人员的共享专业知识 佛罗里达（USF），并实现跨机构合作，以前不可能。该计划包括23 坦帕湾地区的生命科学研究团体，有超过15个NIH资助的研究主要或次要 用户代表每年超过1亿美元的NIH资金。这种计算的科学用例 平台包括癌症、糖尿病、传染病、基因组学、放射组学、人工智能和建模 research.总体而言，85个生命科学研究团体将直接受益于新系统。 MCC运营着一个82节点、1120核的高性能计算（HPC）集群。当前硬件和 软件环境是生命周期的终结，减缓了MCC的研究。USF Health Informatics Institute（HII） 在生命周期结束时使用80节点、1388核心群集。USF最近开发了77节点/1668核心/16 TB受限 研究（符合HIPAA）生命科学群集（RRA），以补充其435节点/9088核心/55 TB 通用集群。RRA包括符合HIPAA的存储，以及用于 管理基因组学和医学成像研究的访问。我们寻求资金购买86个节点（6016 核心）。我们将利用现有的RRA基础架构创建TBLSCC，这是一个163节点/7684核心群集 可供MCC/USF用户使用，可适应计算密集型研究每年20%的增长。这 资源将支持跨机构合作，实现开放科学，并管理不断增长的需求 利用MCC/USF研究需求共享的计算资源，USF研究计算专业知识， 和MCC共享服务计算专业知识。 MCC和USF位于同一地点，每年有近3亿美元的NIH资金。MCC是佛罗里达州唯一一家 NCI指定的综合癌症中心，拥有创新研究，包括综合数学 肿瘤学和机器学习。USF作为卓越的研究机构进行高影响力的全球研究 他是佛罗里达的一所大学，在美国公立研究型大学中，在创造新专利方面排名第八。的 TBLSCC将支持这个充满活力的生命科学研究社区，并为以健康为重点的 创新。

Project Summary/Abstract Funds are requested for the Tampa Bay Life Sciences Computing Commons (TBLSCC), to refresh outdated equipment and expand existing hardware (84% net increase in cores). The TBLSCC will serve as a catalyst to consolidate life-sciences based compute capacity, resulting in fourfold expansion of the existing facility. The TBLSCC will meet current demands, support recent NIH-funded growth in quantitative sciences, leverage the shared expertise of computational researchers at Moffitt Cancer Center (MCC) and the University of South Florida (USF), and enable cross-institutional collaboration not previously possible. This proposal includes 23 life sciences research groups in the Tampa Bay area, with more than 15 NIH funded research Major or Minor Users representing over $100 million in annual NIH funding. The scientific use cases for this computational platform include cancer, diabetes, infectious disease, genomics, radiomics, artificial intelligence, and modelling research. Overall, 85 life sciences research groups would directly benefit from the new system. MCC operates an 82-node, 1120-core high-performance computing (HPC) cluster. The current hardware and software environment is end-of-life, slowing MCC research. Likewise, the USF Health Informatics Institute (HII) uses an 80 node, 1388 core cluster at end of life. USF recently developed a 77 node/1668 core/16TB restricted research (HIPAA-compliant) life sciences cluster (RRA) to complement their 435 node/9088 core/55 TB general-purpose cluster. RRA includes HIPAA-compliant storage, as well as policies and procedures for managing access for genomics and medical imaging research. We seek funds to purchase 86 nodes (6016 cores). We will leverage the existing RRA infrastructure to create the TBLSCC, a 163 node/7684 core cluster available for MCC/USF users that can accommodate 20% annual growth in computing intensive research. This resource will support cross-institutional collaboration, enable open science, and manage increased demands on computational resources leveraging shared MCC/USF research needs, USF research computing expertise, and MCC shared services computational expertise. MCC and USF are co-located with almost $300 million per year of NIH funding. MCC is the only Florida-based NCI-designated Comprehensive Cancer Center with innovative research, including Integrated Mathematical Oncology and Machine Learning. USF performs high-impact global research as a Preeminent Research University in Florida and is eighth among American public research universities in generating new patents. The TBLSCC will support this vibrant life science research community and provide a platform for health-focused innovations.