Epigenetic Age Acceleration Impacts Racial and Neighborhood Disparities in Chronic Low Back Pain
Epigenetic Age Acceleration Impacts Racial and Neighborhood Disparities in Chronic Low Back Pain
批准号:
10431156
负责人:
Pamela Jackson
金额:
$4.94万
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
已结题
起止时间:
2022-04-15 至 2023-03-31
关键词:
AccelerationAddressAdultAffectAgeAge of OnsetAgingBiologicalBiological AgingBiology of AgingBlack AmericanBlack PopulationsBlack raceChronicChronic DiseaseChronic low back painChronologyCitiesCross-Sectional StudiesDNA MethylationDevelopmentDiseaseElderlyEmploymentEnvironmentEnvironmental ExposureEpigenetic ProcessExhibitsExposure toFamilyFemaleGene ExpressionGenesGoalsHealth Care CostsHealth Disparities ResearchHousingIndividualInterventionLife ExpectancyLinkMediatingMentorsMethodsMethylationMinorityModificationMorbidity - disease rateNatureNeighborhoodsPainPain-FreePathway interactionsPlayPopulationPovertyProcessQuality of lifeRaceReduce health disparitiesResearchResourcesRoleSeveritiesSex DifferencesSocial EnvironmentStressTrainingUnited StatesUniversitiesWeatherWomanWorkage relatedbasebuilt environmentchronic paincostdeprivationdisabilitydisorder riskepigenomicsexperiencegeographic disparityhealth disparityimprovedinnovationmalemenmethylation patternmortalitypain outcomepain sensitivityprogramspsychosocialracial differenceracial disparityrecruitsexsocial culturesocioeconomicsstressortheories
中文摘要
摘要
英文摘要
ABSTRACT
Chronic low back pain (cLBP) is an age-related condition that affects over 60% of older adults and costs up to
$315 billion annually. The burden of age-related diseases, including cLBP, disproportionately impacts Black
Americans and residents of high deprivation neighborhoods. High deprivation neighborhoods have a high
concentration of poverty and lack socioeconomic resource-based indicators such as employment and quality
housing. Disturbingly, life expectancy may be up to 20 years shorter for residents of high deprivation
neighborhoods. Yet, the biological mechanisms that link living as a Black American, high deprivation
neighborhoods, worse cLBP outcomes, and shortened life expectancy remain unclear. Epigenetic changes
such as DNA methylation (DNAm) link environmental exposures to gene expression and may affect disease
risk. Such epigenetic modifications may affect an individual’s biological (epigenetic) age, which can be
estimated with DNAm patterns. Though epigenetic age acceleration (EpAA) strongly predicts mortality and has
been observed in many age-related conditions, including chronic pain, it remains unclear whether EpAA can
explain the relationship between neighborhood deprivation and racial disparities in cLBP. Our central
hypothesis is that Blacks and residents of high deprivation neighborhoods experience higher levels of stress
that exert “wear and tear” on the body and epigenetically accelerate age. Our long-term goal is to improve age-
related conditions by uncovering biological mechanisms for place-based (e.g., geographic) disparities in age-
related chronic conditions. The objective of this study is to examine the relationships between EpAA with
neighborhood deprivation, race, and cLBP. Using Hannum’s approach for epigenetic age calculation, we will
examine EpAA from 50 Black and 50 White men and women, including equal numbers of cLBP and pain-free
controls. Aim #1: To investigate the relationship between EpAA with cLBP and status and severity. Aim #2: To
examine the associations between EpAA with neighborhood deprivation, race, and sex. Aim #3: To explore
whether EpAA mediates the relationship between neighborhood deprivation and cLBP severity. Our findings
will significantly impact health disparities research by pointing towards one pathway for the onset and course of
age-related conditions.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
Heat Islands and Chronic Disease: Could African Americans Be More Vulnerable to Heat-Related Health Impacts?
热岛和慢性病:非裔美国人是否更容易受到热相关健康影响?
DOI:
--
发表时间:
2022
期刊:
Journal of National Black Nurses' Association : JNBNA
影响因子:
--
作者:
[Jackson,Pamela, Larkin,Danielle, Kinnie,KiariR, Aroke,EdwinN]
通讯作者:
Aroke,EdwinN
海外基金