Next generation Magnetoencephalography for human social neuroscience

项目摘要 该提案为人类社会神经科学开发了下一代脑磁图（MEG）， 结合了最新的光泵磁力计（OPMs）和磁泵磁力计技术， 屏蔽室（MSR）。成功完成拟议的研究和开发将提高MEG的 易于使用，使有史以来第一次2人面对面的MEG记录的社会互动。动机是 迫切需要改善人类神经成像的相关性-包括直立，社会运动- 基于头皮的传感器代表了最有前途的一组技术，这些技术现在可用， 预计在未来几十年内将有重大改进。而脑电图（EEG） 和功能近红外光谱（fNIRS）目前能够进行这种记录，两者都受到 这些限制将被“不受约束的”MEG补充或改善。在此背景下，研究 这项建议有三个目标。首先，Aim 1集成了最新一代的OPM传感器和MSR 该技术为OPM-MEG实验提供了下一代平台。这些数据提供了一个积极的 控制使用该系统进行Aim 2中的多人、运动耐受神经成像。最后，在目标3中， 评估传感器安装策略和源重建策略，以避免模糊的部分， 可以降低成本，提高实验的便利性。建议的工作将由一个组装的 团队由全球领先的OPM-MEG、磁屏蔽、社会福利和医疗保健领域的学术和行业专家组成， 神经成像和神经成像数据分析。

PROJECT SUMMARY This proposal develops the next generation magnetoencephalography (MEG) for human social neuroscience by combining the latest available technology in optically-pumped magnetometers (OPMs) and magnetically shielded rooms (MSRs). Successful completion of the proposed research and development will enhance MEG's ease of use to enable the first ever 2-person face-to-face MEG recordings of social interactions. Motivated by a pressing need to improve the relevance of human neuroimaging - which includes upright, social movement - scalp-based sensors represent the most promising set of technologies that are both available now and are also expected to enjoy major improvements over the next several decades. While electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) are currently capable of such recordings, both suffer from limitations that would be complimented or ameliorated by “untethered” MEG. Within this context, the research objectives of this proposal are threefold. First, Aim 1 integrates the latest generation of OPM sensors and MSR technology to deliver a next generation platform for OPM-MEG experiments. These data, then provide a positive control to use this system for multi-person, movement tolerant neuroimaging in Aim 2. Finally, in Aim 3 we will evaluate sensor mounting strategies and source reconstructions strategies that will avoid obscuring parts of the face and could reduce cost and improve experimental ease. The work proposed will conducted by an assembled team of the world's leading academic and industry experts in OPM-MEG, magnetic shielding, social neuroimaging, and neuroimaging data analysis.