Next generation Magnetoencephalography for human social neuroscience

项目总结 这项提议为人类社会神经科学开发了下一代脑磁图(MEG)， 结合了光泵磁强计(OPM)和磁强计的最新可用技术 屏蔽室(MSR)。成功完成拟议的研究和开发将增强MEG的 易于使用，首次实现两人面对面的脑磁图社交互动录音。激励因素是 迫切需要提高人类神经成像的相关性--包括直立的社会运动-- 基于头皮的传感器代表了一组最有前途的技术，这些技术既可以使用，也可以 预计在未来几十年内将有重大改进。而脑电(EEG) 和功能性近红外光谱(FNIR)目前能够进行这样的记录，两者都受到 不受束缚的梅格会称赞或改善的限制。在此背景下，这项研究 这项提案的目标有三个。首先，AIM 1集成了最新一代的OPM传感器和MSR 为OPM-MEG实验提供下一代平台的技术。这些数据提供了一个积极的 在目标2中控制使用该系统进行多人运动耐受神经成像。最后，在目标3中，我们将 评估传感器安装策略和源重建策略，以避免模糊部分 可以降低成本，提高实验的简易性。拟议的工作将由一个组装好的 由世界领先的学术和行业专家组成的团队，在OPM-MEG、磁屏蔽、社会 神经成像，以及神经成像数据分析。

PROJECT SUMMARY This proposal develops the next generation magnetoencephalography (MEG) for human social neuroscience by combining the latest available technology in optically-pumped magnetometers (OPMs) and magnetically shielded rooms (MSRs). Successful completion of the proposed research and development will enhance MEG's ease of use to enable the first ever 2-person face-to-face MEG recordings of social interactions. Motivated by a pressing need to improve the relevance of human neuroimaging - which includes upright, social movement - scalp-based sensors represent the most promising set of technologies that are both available now and are also expected to enjoy major improvements over the next several decades. While electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) are currently capable of such recordings, both suffer from limitations that would be complimented or ameliorated by “untethered” MEG. Within this context, the research objectives of this proposal are threefold. First, Aim 1 integrates the latest generation of OPM sensors and MSR technology to deliver a next generation platform for OPM-MEG experiments. These data, then provide a positive control to use this system for multi-person, movement tolerant neuroimaging in Aim 2. Finally, in Aim 3 we will evaluate sensor mounting strategies and source reconstructions strategies that will avoid obscuring parts of the face and could reduce cost and improve experimental ease. The work proposed will conducted by an assembled team of the world's leading academic and industry experts in OPM-MEG, magnetic shielding, social neuroimaging, and neuroimaging data analysis.