Core D. Rodent Behavior Core

项目摘要-啮齿动物行为核心 本申请寻求资金，以继续智力与发展研究所 加州大学戴维斯分校残疾研究中心(IDDRC)。IDDRC成立于2013年 是该网络14个国际数据中心中最新的一个。加拿大皇家银行的目标是支持国际发展研究中心的项目 转译大鼠和小鼠模型以促进对大鼠行为结局的理解和治疗 IDDS的遗传、神经解剖学、免疫学和环境原因。RBC旨在解决 三个具体目标。目标1是提供创新的、高质量的、最先进的老鼠行为测试和 以提高IDD研究的质量和生产率。加拿大皇家银行将通过提供一个 全面的神经行为分析和相关服务，服务级别从 就加拿大皇家银行工作人员全面实施这项研究进行咨询。目标2是提供学习机会 受训人员和教员将成为啮齿动物行为测试程序、实验设计和 对数据的准确解释。这一目标将由提供参与生命周期的加拿大皇家银行工作人员来实现 每项研究，从研究设计和分析选择的初步咨询到实践培训和监督 在对数据解释和稿件的输入和赠款进行咨询的分析中 申请。目标3是协助发展和发展中心网络传播最佳做法和标准化 啮齿动物行为测试协议。这一目标将通过利用国际公认的 RBC领导层在小鼠和大鼠行为分析方面的专业知识，以发展合作和咨询 与IDDRC的其他啮齿动物核心一起；参加IDDRC核心人员的新的、专门的跨部门培训 行为分析；以及验证啮齿动物行为分析的标准化方案。投入到所有活动中 在解决这些目标时，RBC的有效性是临床前研究的严密性和重复性的必要条件。这个 RBC努力确保所有IDDRC研究包括必要的对照分析，进行两次或两次以上 行为领域内的确证分析，重复第二个独立队列中的发现，使用繁殖 获得基因控制的策略，使用足以获得统计能力的群体大小，并使用男性 而女性则将性别视为一个生物变量。加拿大皇家银行的负责人是杰奎琳·克劳利博士。

PROJECT SUMMARY – RODENT BEHAVIOR CORE The present application seeks funding to continue the MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of California, Davis. The IDDRC was launched in 2013 and is the newest of the 14 IDDRCs in the network. The goal of the RBC is to support IDDRC projects using translational rat and mouse models to advance understanding and treatment of the behavioral outcomes of genetic, neuroanatomical, immunological, and environmental causes of IDDs. The RBC is designed to address three specific aims. Aim 1 is to provide innovative, high quality, state-of-the-art behavioral testing of mice and rats to enhance the quality and productivity of IDD research. The RBC will address this aim by offering a comprehensive battery of neurobehavioral assays and related services, with tiers of service ranging from consultation to full implementation of the study by RBC staff. Aim 2 is to provide learning opportunities for trainees and faculty to become expert in rodent behavioral testing procedures, experimental design, and accurate interpretation of data. This aim will be addressed by RBC staff offering involvement in the life cycle of each study, from initial consultation in study design and selection of assays to hands-on training and supervision in implementation of assays to consultation on data interpretation and input on manuscripts and grant applications. Aim 3 is to contribute to the IDDRC network in disseminating best practices and standardizing rodent behavioral testing protocols. This aim will be addressed by leveraging the internationally recognized expertise of the RBC leadership in mouse and rat behavior assays to develop collaborations and consultations with other IDDRC Rodent Cores; to participate in cross-IDDRC training of core personnel on novel, specialized behavioral assays; and to validate standardized protocols for rodent behavioral assays. Infused in all activities of the RBC as it addresses these aims is the imperative for rigor and reproducibility in preclinical research. The RBC strives to ensure that all IDDRC studies include the necessary control assays, conduct two or more corroborative assays within a behavioral domain, replicate findings in a second independent cohort, use breeding strategies to obtain genotype controls, employ group sizes sufficient to achieve statistical power, and use males and females to address sex as a biological variable. The Director of the RBC is Jacqueline Crawley, PhD.