Core D. Rodent Behavior Core

核心 D. 啮齿动物行为核心

• 批准号: 10220105
• 负责人: Jacqueline N Crawley
• 金额: $ 15.32万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10220105
• 关键词: 15q; 16p11.2; Address; Angelman Syndrome; Applications Grants; Behavior; Behavior Therapy; Behavioral; Behavioral Assay; Biological; Biological Assay; Biological Models; Breeding; California; Clinical; Collaborations; Communities; Consultations; Country; Data Analyses; Development; Diagnosis; Doctor of Philosophy; Down Syndrome; Ensure; Experimental Designs; Face; Faculty; Family; Female; Foundations; Fragile X Syndrome; Funding; Genetic; Genotype; Goals; Human; Human Resources; Immune system; Immunologics; Institutes; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; International; Leadership; Learning; Life Cycle Stages; Manuscripts; Mediating; Methods; Mission; Modeling; Mus; Neurobiology; Outcome Measure; Phelan-McDermid syndrome; Prevention; Procedures; Productivity; Protocols documentation; Publications; Quality of life; Rattus; Reproducibility; Research; Research Design; Research Personnel; Research Project Grants; Research Support; Rett Syndrome; Risk Factors; Rodent; Rodent Model; Services; Standardization; Supervision; Symptoms; System; Training; Translational Research; United States National Institutes of Health; Universities; autism spectrum disorder; behavior test; behavioral outcome; behavioral phenotyping; career; cohort; design; experimental study; improved; innovation; insight; male; mouse model; neurobehavioral; novel; pre-clinical research; relating to nervous system; sex

PROJECT SUMMARY – RODENT BEHAVIOR CORE The present application seeks funding to continue the MIND Institute Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of California, Davis. The IDDRC was launched in 2013 and is the newest of the 14 IDDRCs in the network. The goal of the RBC is to support IDDRC projects using translational rat and mouse models to advance understanding and treatment of the behavioral outcomes of genetic, neuroanatomical, immunological, and environmental causes of IDDs. The RBC is designed to address three specific aims. Aim 1 is to provide innovative, high quality, state-of-the-art behavioral testing of mice and rats to enhance the quality and productivity of IDD research. The RBC will address this aim by offering a comprehensive battery of neurobehavioral assays and related services, with tiers of service ranging from consultation to full implementation of the study by RBC staff. Aim 2 is to provide learning opportunities for trainees and faculty to become expert in rodent behavioral testing procedures, experimental design, and accurate interpretation of data. This aim will be addressed by RBC staff offering involvement in the life cycle of each study, from initial consultation in study design and selection of assays to hands-on training and supervision in implementation of assays to consultation on data interpretation and input on manuscripts and grant applications. Aim 3 is to contribute to the IDDRC network in disseminating best practices and standardizing rodent behavioral testing protocols. This aim will be addressed by leveraging the internationally recognized expertise of the RBC leadership in mouse and rat behavior assays to develop collaborations and consultations with other IDDRC Rodent Cores; to participate in cross-IDDRC training of core personnel on novel, specialized behavioral assays; and to validate standardized protocols for rodent behavioral assays. Infused in all activities of the RBC as it addresses these aims is the imperative for rigor and reproducibility in preclinical research. The RBC strives to ensure that all IDDRC studies include the necessary control assays, conduct two or more corroborative assays within a behavioral domain, replicate findings in a second independent cohort, use breeding strategies to obtain genotype controls, employ group sizes sufficient to achieve statistical power, and use males and females to address sex as a biological variable. The Director of the RBC is Jacqueline Crawley, PhD.

项目摘要-啮齿动物行为核心 本申请寻求资金，以继续智力和发展研究所 残疾人研究中心（IDDRC）在加州大学戴维斯分校。IDDRC于2013年启动 并且是网络中14个IDDRC中最新的一个。RBC的目标是支持IDDRC项目， 翻译大鼠和小鼠模型，以促进理解和治疗的行为结果， 遗传、神经解剖学、免疫学和环境因素。RBC旨在解决 三个具体目标。目标1是提供创新的、高质量的、最先进的小鼠行为测试， 以提高碘缺乏病研究的质量和效率。RBC将通过提供一个 全面的神经行为检测和相关服务，服务级别从 咨询，以全面实施研究的RBC工作人员。目标2是为以下人员提供学习机会： 学员和教师成为啮齿动物行为测试程序，实验设计， 数据的准确解释。这一目标将由RBC工作人员参与生命周期， 每项研究，从研究设计和试验选择的初步咨询到实践培训和监督 在实施分析、数据解释咨询以及手稿和赠款输入方面 应用.目标3是促进非洲工发十年网络传播最佳做法， 啮齿动物行为测试方案。这一目标将通过利用国际公认的 RBC领导层在小鼠和大鼠行为测定方面的专业知识，以开展合作和咨询 与其他IDDRC啮齿类动物核心;参加跨IDDRC核心人员的新的、专门的 行为测定;以及验证啮齿动物行为测定的标准化方案。融入所有活动 红细胞，因为它解决了这些目标是必要的严谨性和重现性，在临床前研究。的 RBC努力确保所有IDDRC研究包括必要的对照试验，进行两次或两次以上 行为领域内的确证性测定，在第二个独立队列中复制发现，使用育种 策略，以获得基因型控制，采用组规模足以实现统计权力，并使用男性 而女性则将性别视为一个生物变量。RBC的主任是Jacqueline Crawley博士。