Rodent Behavior Core

啮齿动物行为核心

• 批准号: 8659021
• 负责人: Jacqueline N Crawley
• 金额: $ 15.42万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-24 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8659021
• 关键词: Animal Model; Applications Grants; Arts; Behavior; Behavioral; Behavioral Assay; Behavioral Symptoms; Biological; Biological Assay; Clinical Trials; Collaborations; Consultations; Core Facility; Data; Equipment; Experimental Designs; Gene Mutation; Genetic; Goals; Health Services Accessibility; Human; Immune; Inbred Strains Mice; Institutes; Knowledge; Manuscripts; Mental Retardation and Developmental Disabilities Research Centers; Modeling; Mus; Mutant Strains Mice; Pharmaceutical Preparations; Phenotype; Procedures; Protocols documentation; Publications; Rattus; Research; Research Personnel; Resources; Rodent; Rodent Model; Services; Site; Supervision; Testing; Therapeutic; Tissue Harvesting; Toxic Environmental Substances; Training; behavior test; behavioral pharmacology; design; experience; innovation; intellectual and developmental disability; interest; investigator training; medical schools; meetings; member; outreach; pre-clinical; response

The UC Davis MIND Institute IDDRC Rodent Behavior Core (RBC) is fundamental to Center projects seeking to understand the biological mechanisms underlying IDD and to pursue translational discovery of therapeutics. This is a completely new core that builds on existing and newly available resources and expertise at the MIND Institute and UC Davis. Its goal is to meet the high demand for behavioral testing of rodent models of IDD at UC Davis. The RBC will assist investigators with IDDRC projects in generating high-quality behavioral data for publication, preclinical discoveries to inform human clinical trials, and pilot data for new studies. Further, the availability of the services of the RBC is likely to encourage additional UC Davis researchers to become interested in entering the IDD research field and becoming members of the IDDRC, and we will support this interest through active outreach efforts. Comprehensive behavioral assays relevant to IDD, including those developed by Drs. Crawley and Berman, are employed worldwide to understand causal mechanisms and develop effective therapeutics. The proposed RBC will employ standardized and innovative behavioral assays relevant to the behavioral symptoms of IDD. Services will include (a) access to modern, efficient, start-of-the-art behavioral testing facilities; (b) training for investigators and their staff" in behavioral assay procedures and the use of behavioral testing equipment; (c) hands-on supervision in all aspects of behavioral testing and equipment use; (d) consultation on experimental design and interpretation of results; (e) assistance in developing new assays required by users; (f) training and supervision in drug administration for behavioral pharmacology studies; (g) access to facilities for harvesting tissue from behaviorally tested mice and rats; (h) access to mutant mouse and rat models; (i) guidance to access related resources at UC Davis, including core facilities for genetics and for generating new lines of mutant mice; and (j) facilitation of collaborations between IDDRC investigators. Services will further include (k) consultation for preparing lACUC protocols, grant applications, and manuscripts. In addition, the core will offer (I) direct behavioral testing services conducted by core staff. Expertise of the core director, co-director, and managers includes extensive knowledge and experience in animal models of IDD conditions, behavioral phenotyping of mice with targeted gene mutations, behavioral phenotyping of inbred strains of mice and rats, and behavioral responses to drug treatments, immune challenges, and environmental toxins in mice and rats. Mouse facilities are located at the UC Davis School of Medicine campus in Sacramento. Rat facilities are located at the nearby main campus in Davis. A high level of scientific and practical interactions is already in place between the two sites. Five tiers of service usage will be offered: (1) consultation; (2) unsupervised use of equipment available in the core facilities; (3) training and supervision in conducting behavioral tests using core equipment; (4) battery of assays conducted by core staff; and (5) tailored sets of assays conducted by core staff. Combinations of services will be designed to match the needs of each user.

UC Davis Mind Institute IDDRC啮齿动物行为核心（RBC）是寻求中心项目的基础 了解IDD的生物学机制并追求治疗剂的翻译发现。 这是一个全新的核心，基于现有和新的资源和专业知识 研究所和加州大学戴维斯分校。它的目标是满足IDD啮齿动物模型的行为测试的高需求 加州大学戴维斯分校。加拿大皇家银行将协助调查人员进行IDDRC项目，以生成高质量的行为数据 出版物，临床前的发现，以告知人类临床试验，并进行新研究的试点数据。此外， 加拿大皇家银行服务的可用性可能鼓励其他UC Davis研究人员成为 有兴趣进入IDD研究领域并成为IDDRC的成员，我们将支持这一点 通过积极的外展工作的兴趣。 与IDD相关的全面行为测定，包括DRS开发的行为分析。克劳利和 伯曼（Berman）在全球范围内受雇，以了解因果机制并发展有效的治疗疗法。这 拟议的RBC将采用与行为症状相关的标准化和创新的行为测定 IDD。服务将包括（a）访问现代，高效，开始行为测试设施； （b） 在行为测定程序中对调查人员及其人员的培训和行为测试的使用 设备; （c）行为测试和设备使用的各个方面的动手监督； （d）咨询 实验设计和结果解释； （e）协助开发用户要求的新测定； （f）行为药理学研究药物管理培训和监督； （g）进入设施 用于从行为测试的小鼠和大鼠那里收集组织； （h）访问突变小鼠和大鼠模型； （我） 在加州大学戴维斯分校访问相关资源的指南，包括遗传学的核心设施和生成新的 突变小鼠的线； （j）IDDRC调查人员之间的合作促进。服务将进一步 包括（k）准备LACUC协议，赠款申请和手稿的咨询。另外， 核心将提供（i）由核心人员进行的直接行为测试服务。 核心主任，联合导演和经理的专业知识包括广泛的知识和经验 IDD条件的动物模型，具有靶向基因突变的小鼠的行为表型，行为 小鼠和大鼠近交菌株的表型，以及对药物治疗的行为反应，免疫 挑战和小鼠和大鼠的环境毒素。鼠标设施位于加州大学戴维斯分校 萨克拉曼多的医学校园。老鼠设施位于戴维斯附近的主要校园。高水平 两个站点之间已经进行了科学和实用的互动。五层服务使用情况将是 提供：（1）咨询； （2）核心设施中可用的设备无监督； （3）培训和 使用核心设备进行行为测试的监督； （4）由核心人员进行的一系列测定； （5）由核心人员进行的量身定制的测定。服务的组合将旨在与 每个用户的需求。