Rodent Behavior Core

啮齿动物行为核心

• 批准号: 8659021
• 负责人: Jacqueline N Crawley
• 金额: $ 15.42万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-24 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8659021
• 关键词: Animal Model; Applications Grants; Arts; Behavior; Behavioral; Behavioral Assay; Behavioral Symptoms; Biological; Biological Assay; Clinical Trials; Collaborations; Consultations; Core Facility; Data; Equipment; Experimental Designs; Gene Mutation; Genetic; Goals; Health Services Accessibility; Human; Immune; Inbred Strains Mice; Institutes; Knowledge; Manuscripts; Mental Retardation and Developmental Disabilities Research Centers; Modeling; Mus; Mutant Strains Mice; Pharmaceutical Preparations; Phenotype; Procedures; Protocols documentation; Publications; Rattus; Research; Research Personnel; Resources; Rodent; Rodent Model; Services; Site; Supervision; Testing; Therapeutic; Tissue Harvesting; Toxic Environmental Substances; Training; behavior test; behavioral pharmacology; design; experience; innovation; intellectual and developmental disability; interest; investigator training; medical schools; meetings; member; outreach; pre-clinical; response

The UC Davis MIND Institute IDDRC Rodent Behavior Core (RBC) is fundamental to Center projects seeking to understand the biological mechanisms underlying IDD and to pursue translational discovery of therapeutics. This is a completely new core that builds on existing and newly available resources and expertise at the MIND Institute and UC Davis. Its goal is to meet the high demand for behavioral testing of rodent models of IDD at UC Davis. The RBC will assist investigators with IDDRC projects in generating high-quality behavioral data for publication, preclinical discoveries to inform human clinical trials, and pilot data for new studies. Further, the availability of the services of the RBC is likely to encourage additional UC Davis researchers to become interested in entering the IDD research field and becoming members of the IDDRC, and we will support this interest through active outreach efforts. Comprehensive behavioral assays relevant to IDD, including those developed by Drs. Crawley and Berman, are employed worldwide to understand causal mechanisms and develop effective therapeutics. The proposed RBC will employ standardized and innovative behavioral assays relevant to the behavioral symptoms of IDD. Services will include (a) access to modern, efficient, start-of-the-art behavioral testing facilities; (b) training for investigators and their staff" in behavioral assay procedures and the use of behavioral testing equipment; (c) hands-on supervision in all aspects of behavioral testing and equipment use; (d) consultation on experimental design and interpretation of results; (e) assistance in developing new assays required by users; (f) training and supervision in drug administration for behavioral pharmacology studies; (g) access to facilities for harvesting tissue from behaviorally tested mice and rats; (h) access to mutant mouse and rat models; (i) guidance to access related resources at UC Davis, including core facilities for genetics and for generating new lines of mutant mice; and (j) facilitation of collaborations between IDDRC investigators. Services will further include (k) consultation for preparing lACUC protocols, grant applications, and manuscripts. In addition, the core will offer (I) direct behavioral testing services conducted by core staff. Expertise of the core director, co-director, and managers includes extensive knowledge and experience in animal models of IDD conditions, behavioral phenotyping of mice with targeted gene mutations, behavioral phenotyping of inbred strains of mice and rats, and behavioral responses to drug treatments, immune challenges, and environmental toxins in mice and rats. Mouse facilities are located at the UC Davis School of Medicine campus in Sacramento. Rat facilities are located at the nearby main campus in Davis. A high level of scientific and practical interactions is already in place between the two sites. Five tiers of service usage will be offered: (1) consultation; (2) unsupervised use of equipment available in the core facilities; (3) training and supervision in conducting behavioral tests using core equipment; (4) battery of assays conducted by core staff; and (5) tailored sets of assays conducted by core staff. Combinations of services will be designed to match the needs of each user.

加州大学戴维斯分校MIND研究所IDDRC啮齿动物行为核心（RBC）是中心项目寻求 了解IDD潜在的生物学机制，并寻求治疗方法的转化发现。 这是一个全新的核心，建立在现有的和新的可用资源和专业知识在MIND 研究所和加州大学戴维斯分校其目标是满足对IDD啮齿动物模型行为测试的高需求， 加州大学戴维斯分校。RBC将协助IDDRC项目的调查人员生成高质量的行为数据， 出版物，临床前发现，为人类临床试验提供信息，以及新研究的试点数据。此夕h RBC服务的可用性可能会鼓励更多的加州大学戴维斯分校研究人员成为 我们有兴趣进入IDD研究领域，并成为IDDRC的成员，我们将支持这一点 通过积极的宣传努力。 与IDD相关的综合行为测定，包括由Crawley博士和 伯曼，受雇于世界各地了解因果机制和开发有效的治疗方法。的 拟议的RBC将采用与行为症状相关的标准化和创新的行为分析 的IDD。服务将包括（a）使用现代、高效、最先进的行为测试设施;（B） 对研究人员及其工作人员进行行为分析程序和行为测试使用方面的培训 （c）在行为测试和仪器使用的各个方面进行实际监督;（d）就 （e）协助开发用户所需的新化验方法; (f)行为药理学研究药物管理方面的培训和监督;（g）使用设施 从行为测试的小鼠和大鼠中获取组织;（h）获得突变小鼠和大鼠模型;（i） 指导访问加州大学戴维斯分校的相关资源，包括遗传学和产生新的 突变小鼠品系;以及（j）促进IDDRC研究者之间的合作。服务将进一步 包括（k）为准备IACUC协议、赠款申请和手稿提供咨询。此外该 核心将提供（I）由核心工作人员进行的直接行为测试服务。 核心董事、联席董事和经理的专业知识包括以下方面的广泛知识和经验： IDD条件的动物模型，具有靶向基因突变的小鼠的行为表型， 近交系小鼠和大鼠的表型，以及对药物治疗的行为反应，免疫 挑战，以及小鼠和大鼠的环境毒素。鼠标设施位于加州大学戴维斯分校的 萨克拉门托的医学院。老鼠设施位于附近的戴维斯主校区。高水平的 两个地点之间已经建立了科学和实际的互动关系。五个服务使用层次将是 提供：（1）咨询;（2）不受监督地使用核心设施中的设备;（3）培训和 监督使用核心设备进行行为测试;（4）由核心人员进行的一系列测试; 和（5）由核心人员进行的定制的测定集。服务的组合将被设计为与 每个用户的需求。