Effects of Music Training on Neurodevelopment and Associated Health Outcomes

音乐训练对神经发育和相关健康结果的影响

基本信息

批准号：
10432713
负责人：
Assal Habibi
金额：
$ 56.94万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10432713
关键词：
Address Adherence Adult Affective Age Anterior Arts Auditory Behavioral Books Brain Child Clinical Communities Complex Control Groups Correlation Studies Cross-Sectional Studies Cultural Diversity Development Exhibits Feasibility Studies Focus Groups Foundations Functional Magnetic Resonance Imaging Future Goals Health Hispanic Home environment Image Individual Intervention Intervention Studies Intervention Trial Investigation Lead Life Light Low income Measurement Measures Motivation Motor Motor Cortex Motor Skills Multimodal Imaging Music Neuronal Plasticity Obesity Outcome Outcome Study Participant Phase Play Population Prefrontal Cortex Process Prospective Studies Randomized Randomized Controlled Trials Regulation Reporting Research Personnel Rewards Role Sampling Schools Selection Bias Services Signal Transduction Societies Socioeconomic Status Structure Students Suggestion System Testing Time TimeLine Training Training Programs Visual system structure Work Youth after-school program base behavior change behavior measurement brain behavior brain circuitry cingulate cortex cognitive function cohort community involvement computerized cost effective design early adolescence ethnic minority feasibility testing high risk middle childhood minority children musician neural recruitment neurodevelopment neuroimaging novel strategies primary endpoint primary outcome programs recruit response retention rate secondary outcome sensory system somatosensory success trial design underserved community

项目摘要

Project Summary While there is a growing body of evidence suggesting that music training benefits brain development, the evidence is not conclusive and rigorously designed randomized control trial (RCT) neuroimaging studies are needed to provide a definitive answer to whether and which brain circuits are enhanced by music training and how. We aim to address this gap: we propose an RCT to robustly test the hypothesis that systematic music training will benefit development of brain inhibition control circuitry among Hispanic youth from underserved communities. Prior work including ours provided suggestive evidence that long-term music training in children may lead to neuroplastic functional changes in the associated frontal brain circuitry and improvement of inhibitory control. During the R61 phase, we will test the feasibility (recruitment, retention, adherence and intent to continue) of a RCT on 40 Hispanic children between ages 6-8, of whom will be assigned to a 24-month intervention trial targeting community and group-focused after school music training (MG) or to an after-school program comprising arts, book clubs, ethnic and culture studies without specific focus on systematic music training, the control group (CG). We will use multi-modal imaging and behavioral probes to measure two aspects of inhibition control: (1) response inhibition by using a stop-signal task and (2) delayed gratification using a computerized task wherein children will be asked to choose immediate vs. delayed monetary rewards. Neuroimaging measures will be obtained twice, pre and post 2-yr intervention. Behavioral measures will be obtained at baseline and yearly thereafter. During the R33 phase, we will additionally recruit 74 Hispanic children between ages 6-8 and assess them with the same imaging and behavioral measurements using the same testing timeline as in R61. This is the first RCT using neuroimaging to assess whether and how music training enhances brain inhibition control circuitry. By focusing on Hispanic children from underserved communities our results will shed light on the effects of music training on development of brain function. And early life brain-to-behavior changes induced by music training may have long-term positive effects on an individual's health and success.

项目摘要尽管越来越多的证据表明音乐训练会使大脑的发展有益于大脑的发展，但需要证据是确定的，并且需要严格设计的随机对照试验（RCT）神经成像研究，以提供明确的答案，以了解是否以及通过音乐训练增强脑电路以及如何增强脑电路。我们的目的是解决这一差距：我们建议RCT稳健地检验以下假设：系统的音乐训练将使来自服务不足社区的西班牙裔青年对大脑抑制控制电路的发展。包括我们的工作在内的先前工作提供了暗示性的证据，表明儿童的长期音乐训练可能会导致相关额脑电路的神经塑性功能变化并改善抑制性控制。 During the R61 phase, we will test the feasibility (recruitment, retention, adherence and intent to continue) of a RCT on 40 Hispanic children between ages 6-8, of whom will be assigned to a 24-month intervention trial targeting community and group-focused after school music training (MG) or to an after-school program comprising arts, book clubs, ethnic and culture studies without specific focus on systematic music training, the control group （CG）。我们将使用多模式成像和行为探针来测量抑制控制的两个方面：（1）通过使用停止信号任务的响应抑制作用，以及（2）使用计算机化任务延迟满足，要求儿童选择即时与延迟的货币奖励。 2年前后，将获得两次神经影像措施。行为措施将在基线和此后每年获得。在R33阶段，我们还将使用与R61相同的测试时间表进行相同的成像和行为测量，并通过相同的成像和行为测量进行评估。这是第一次使用神经影像来评估音乐训练是否增强大脑抑制控制电路的RCT。通过关注来自服务不足社区的西班牙裔儿童，我们的结果将揭示音乐训练对大脑功能发展的影响。音乐训练引起的早期生命的大脑对行为变化可能会对个人的健康和成功产生长期积极影响。