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Co-Use of Opioid Medications and Alcohol Prevention Study (COAPS)

阿片类药物与酒精预防研究 (COAPS) 的共同使用

基本信息

批准号：
10433369
负责人：
Alina Cernasev
金额：
$ 24.78万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-26 至 2025-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10433369
关键词：
Address Adoption Alcohol consumption Alcohols Analgesics Back Caring Client satisfaction Clinical Research Clinical Trials Clinical trial protocol document Community Pharmacy Consent Consolidated Framework for Implementation Research Consultations Consumption Counseling Data Enrollment Evaluation Foundations Future Health Heavy Drinking Individual Intervention Interview Literature Location Medication Management Mental Depression Mental Health Methods Opiate Addiction Opioid Opioid Analgesics Outcome Pain Pain management Participant Patients Pattern Peer Review Perception Pharmaceutical Preparations Pharmacists Pharmacy facility Positioning Attribute Process Production Public Health Randomized Reporting Research Resources Review Literature Risk Safety Sedation procedure System Testing TimeLine Toxicology Training Urine Ventilatory Depression Work alcohol abuse therapy alcohol intervention alcohol measurement alcohol prevention alcohol risk alcohol screening alcohol seeking behavior alcohol use disorder base brief intervention comorbidity drinking feasibility testing hazard high risk drinking insight mu opioid receptors multi-site trial non-opioid analgesic opioid epidemic opioid use opioid use disorder organizational readiness overdose risk participant retention patient screening peer prescription opioid prescription opioid misuse randomized trial screening screening, brief intervention, referral, and treatment systems research telephone-based ward

项目摘要

PUBLIC HEALTH ABSTRACT Co-use of alcohol and opioid medications is known to be a serious health/safety hazard—yet persists despite these negative ramifications. With limited information available within peer-reviewed literature, large- scale system and clinical research have demonstrated 24-38% of those with alcohol use disorders also have an opioid addiction, with rates of past 30-day opioid medication misuse among those seeking alcohol treatment as high as 68%. Our research has shown that among community pharmacy patients receiving opioid medications for pain management, approximately 20-30% are engaged in co-use of alcohol. Community pharmacy is a highly valuable but underutilized resource and setting for identification and intervention to address the US opioid epi- demic. We propose to adapt, manualize, and test the acceptability, feasibility, and preliminary efficacy of an Alcohol-targeted Brief Intervention-Medication Therapy Management (ABI-MTM) intervention with community pharmacy patients. ABI-MTM will be a pharmacy-based medication management intervention, combined with Screening, Brief Intervention, and Referral to treatment that will target: (1) alcohol use elimination during opioid treatment OR (2) non-opioid pain management substitution (in consultation with the prescriber). We will conduct a small-scale trial in 3 community pharmacy locations wherein we will randomize patients with heavy alcohol use and with non-heavy alcohol use (1-to-1 ratio) to ABI-MTM (n=20) or standard medication counseling (SMC, n=20). Results will demonstrate intervention acceptability, feasibility, and preliminary efficacy. This study will also work to identify pharmacy system and practice-level barriers and facilitators for universal alcohol screening and intervention among opioid recipients. We will develop a mixed methods assessment guide to interview pharmacy technicians (N=20), pharmacists (N=20), and corporate leaders (N=20). Interviews will assess perceptions to- wards screening/intervention, internal organizational challenges, and processes related to ABI-MTM implemen- tation for large-scale research and practice. Altogether, results of this study will provide critical insights, founda- tional data, and strategies for executing a powered trial and possible future system/practice-level implementation.

公共卫生摘要