Feasibility of transcranial histotripsy for pediatric neuro-oncology applications using a hemispherical transducer
使用半球形换能器进行经颅组织解剖用于儿科神经肿瘤学应用的可行性
基本信息
- 批准号:10433621
- 负责人:
- 金额:$ 20.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AblationAcousticsAdoptionAmplifiersAnimalsBenignBrainBrain NeoplasmsCancer EtiologyCellsChildChildhoodChildhood Brain NeoplasmChildhood Malignant Brain TumorClinicalClinical ResearchDevelopmentDiagnosisEmerging TechnologiesFDA approvedFamily suidaeFocused UltrasoundGasesGoalsGrantHeatingHumanLate EffectsLesionLiteratureMechanicsMediatingMethodsModalityModelingMorbidity - disease rateNational Institute of Biomedical Imaging and BioengineeringNeurologicOperative Surgical ProceduresOutcomePhysiologic pulsePlayPopulationProcessQuality of lifeRadiation exposureRadiation therapyResearchResearch PersonnelRiskSafetyScalp structureSecond Primary CancersSeriesShockStressSystemTadpolesTestingThermal Ablation TherapyTissue TherapyTissuesTransducersTremorUltrasonic TransducerUltrasonicsattenuationchemotherapyclinical translationcostcraniumdesignexperimental studyheart damagehigh riskin vivoinnovationlung injurymillisecondmortalitynervous system disorderneuro-oncologynovelpediatric patientspressureresponsesimulation
项目摘要
Pediatric patients have a real and urgent unmet need for less invasive treatments which can efficiently and
safely treat brain tumors without incurring significant late effects. The long-term goal of this proposal is to
develop an efficient non-invasive treatment modality without any late effects for safe treatment of both benign
and malignant pediatric brain tumors. This will be done utilizing tissue-liquification by focused ultrasound
(FUS)-induced histotripsy. The overall objectives in this application are to (i) elucidate the degree to which high
acoustic pressures and non-linear shocking mediate the tissue liquification process and what contribution each
of three possible histotripsy mechanism may play when using a hemispherical FUS transducer; and (ii)
systematically investigate the parameter space that supports mechanical liquification by hemispherical
transducers both ex vivo and in vivo with pediatric skulls in the FUS beam path. The central hypothesis is that
carefully designed experiments can be performed to understand the mechanism of action behind tissue
liquification using low f-number (e.g., hemispherical) transducers, and that histotripsy can be feasibly
accomplished within at least a subset of the pediatric population. The rationale for this project is that
understanding the mechanism responsible for tissue liquification using existing and regulatory approved
hemispherical transcranial FUS transducers, together with in vivo parameter optimization, is likely to offer
strong scientific support for the feasibility of pediatric brain tumor histotripsy treatments. The central hypothesis
will be tested by pursuing two specific aims: 1) conduct carefully designed computational, benchtop, and ex
vivo experiments to determine the contribution each of three possible histotripsy mechanism have on the tissue
liquification process; and 2) investigate the parameter space that supports mechanical liquification by
hemispherical transducers through pediatric skulls. The research proposed in this application is innovative, in
the applicant’s opinion, because it proposes to determine the mechanism of action behind histotripsy tissue
liquification using low f-number FUS transducers, as well as optimize the FUS pulsing parameters. The
proposed research is significant because it is expected to provide a strong scientific justification for further
studies of transcranial histotripsy for the pediatric population. Ultimately, this novel non-invasive treatment
modality has the potential to help the approximately 4,300 children who are diagnosed with brain tumors in the
US every year, 30% of whom do not survive past five years after diagnosis, with a safe an efficient treatment
option.
儿科患者对侵入性更小的治疗有着真实而迫切的需求,这种治疗可以有效和
安全治疗脑瘤,不会招致明显的后遗症。这项提议的长期目标是
开发一种有效的非侵入性治疗方法,安全地治疗这两种良性疾病
和儿童恶性脑瘤。这将通过聚焦超声进行组织液化来完成。
(FUS)诱导的组织学检查。本申请的总体目标是:(I)阐明高
声压和非线性冲击在组织液化过程中的中介作用及其各自的贡献
当使用半球FUS换能器时,三种可能的组织摩擦机制可能起作用;和(Ii)
系统地研究了半球面支持机械液化的参数空间
在体外和体内的换能器,在FUS束路径上有儿科头骨。中心假设是
可以进行精心设计的实验来了解组织背后的作用机制
使用低f数(例如,半球)换能器的液化,并且该组织摩擦检查是可行的
至少在儿科人群的一个子集内完成。这个项目的基本原理是
了解使用现有的和法规批准的组织液化的机制
半球经颅fus换能器,加上活体参数优化,可能会提供
为儿童脑肿瘤组织学治疗的可行性提供了有力的科学支持。中心假说
将通过追求两个具体目标进行测试:1)进行精心设计的计算、台式计算机和
活体实验,以确定三种可能的组织摩擦机制对组织的贡献
液化过程;以及2)研究支持机械液化的参数空间
通过儿童头骨的半球换能器。本申请中提出的研究具有创新性,在
申请人的意见,因为它提议确定组织摩擦组织背后的作用机制
使用低f数FUS换能器进行液化,以及优化FUS脉冲参数。这个
拟议的研究具有重要意义,因为它有望为进一步的
儿童人群经颅组织学检查的研究。最终,这种新的非侵入性治疗
这种模式有可能帮助大约4300名被诊断为脑瘤的儿童
美国每年有30%的人在确诊后五年内不能存活,采用安全有效的治疗方法
选择。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Henrik Carl Axel Odeen其他文献
Henrik Carl Axel Odeen的其他文献
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{{ truncateString('Henrik Carl Axel Odeen', 18)}}的其他基金
Real-time monitoring and treatment evaluation of MR guided focal ultrasound-mediated non-thermal ablation of brain tumors
磁共振引导聚焦超声介导脑肿瘤非热消融的实时监测和治疗评估
- 批准号:
10659248 - 财政年份:2022
- 资助金额:
$ 20.06万 - 项目类别:
Real-time monitoring and treatment evaluation of MR guided focal ultrasound-mediated non-thermal ablation of brain tumors
磁共振引导聚焦超声介导脑肿瘤非热消融的实时监测和治疗评估
- 批准号:
10511064 - 财政年份:2022
- 资助金额:
$ 20.06万 - 项目类别:
Feasibility of transcranial histotripsy for pediatric neuro-oncology applications using a hemispherical transducer
使用半球形换能器进行经颅组织解剖用于儿科神经肿瘤学应用的可行性
- 批准号:
10570948 - 财政年份:2022
- 资助金额:
$ 20.06万 - 项目类别:
Advanced Treatment Endpoint Assessment in MR-guided Focused Ultrasound
MR 引导聚焦超声的高级治疗终点评估
- 批准号:
10115726 - 财政年份:2020
- 资助金额:
$ 20.06万 - 项目类别:
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