Feasibility of transcranial histotripsy for pediatric neuro-oncology applications using a hemispherical transducer
使用半球形换能器进行经颅组织解剖用于儿科神经肿瘤学应用的可行性
基本信息
- 批准号:10433621
- 负责人:
- 金额:$ 20.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-01 至 2024-12-31
- 项目状态:已结题
- 来源:
- 关键词:AblationAcousticsAdoptionAmplifiersAnimalsBenignBrainBrain NeoplasmsCancer EtiologyCellsChildChildhoodChildhood Brain NeoplasmChildhood Malignant Brain TumorClinicalClinical ResearchDevelopmentDiagnosisEmerging TechnologiesFDA approvedFamily suidaeFocused UltrasoundGasesGoalsGrantHeatingHumanLate EffectsLesionLiteratureMechanicsMediatingMethodsModalityModelingMorbidity - disease rateNational Institute of Biomedical Imaging and BioengineeringNeurologicOperative Surgical ProceduresOutcomePhysiologic pulsePlayPopulationProcessQuality of lifeRadiation exposureRadiation therapyResearchResearch PersonnelRiskSafetyScalp structureSecond Primary CancersSeriesShockStressSystemTadpolesTestingThermal Ablation TherapyTissue TherapyTissuesTransducersTremorUltrasonic TransducerUltrasonicsattenuationchemotherapyclinical translationcostcraniumdesignexperimental studyheart damagehigh riskin vivoinnovationlung injurymillisecondmortalitynervous system disorderneuro-oncologynovelpediatric patientspressureresponsesimulation
项目摘要
Pediatric patients have a real and urgent unmet need for less invasive treatments which can efficiently and
safely treat brain tumors without incurring significant late effects. The long-term goal of this proposal is to
develop an efficient non-invasive treatment modality without any late effects for safe treatment of both benign
and malignant pediatric brain tumors. This will be done utilizing tissue-liquification by focused ultrasound
(FUS)-induced histotripsy. The overall objectives in this application are to (i) elucidate the degree to which high
acoustic pressures and non-linear shocking mediate the tissue liquification process and what contribution each
of three possible histotripsy mechanism may play when using a hemispherical FUS transducer; and (ii)
systematically investigate the parameter space that supports mechanical liquification by hemispherical
transducers both ex vivo and in vivo with pediatric skulls in the FUS beam path. The central hypothesis is that
carefully designed experiments can be performed to understand the mechanism of action behind tissue
liquification using low f-number (e.g., hemispherical) transducers, and that histotripsy can be feasibly
accomplished within at least a subset of the pediatric population. The rationale for this project is that
understanding the mechanism responsible for tissue liquification using existing and regulatory approved
hemispherical transcranial FUS transducers, together with in vivo parameter optimization, is likely to offer
strong scientific support for the feasibility of pediatric brain tumor histotripsy treatments. The central hypothesis
will be tested by pursuing two specific aims: 1) conduct carefully designed computational, benchtop, and ex
vivo experiments to determine the contribution each of three possible histotripsy mechanism have on the tissue
liquification process; and 2) investigate the parameter space that supports mechanical liquification by
hemispherical transducers through pediatric skulls. The research proposed in this application is innovative, in
the applicant’s opinion, because it proposes to determine the mechanism of action behind histotripsy tissue
liquification using low f-number FUS transducers, as well as optimize the FUS pulsing parameters. The
proposed research is significant because it is expected to provide a strong scientific justification for further
studies of transcranial histotripsy for the pediatric population. Ultimately, this novel non-invasive treatment
modality has the potential to help the approximately 4,300 children who are diagnosed with brain tumors in the
US every year, 30% of whom do not survive past five years after diagnosis, with a safe an efficient treatment
option.
儿科患者有一个真实的和迫切的未满足的需求,需要更少的侵入性治疗,可以有效和
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Henrik Carl Axel Odeen其他文献
Henrik Carl Axel Odeen的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Henrik Carl Axel Odeen', 18)}}的其他基金
Real-time monitoring and treatment evaluation of MR guided focal ultrasound-mediated non-thermal ablation of brain tumors
磁共振引导聚焦超声介导脑肿瘤非热消融的实时监测和治疗评估
- 批准号:
10659248 - 财政年份:2022
- 资助金额:
$ 20.06万 - 项目类别:
Real-time monitoring and treatment evaluation of MR guided focal ultrasound-mediated non-thermal ablation of brain tumors
磁共振引导聚焦超声介导脑肿瘤非热消融的实时监测和治疗评估
- 批准号:
10511064 - 财政年份:2022
- 资助金额:
$ 20.06万 - 项目类别:
Feasibility of transcranial histotripsy for pediatric neuro-oncology applications using a hemispherical transducer
使用半球形换能器进行经颅组织解剖用于儿科神经肿瘤学应用的可行性
- 批准号:
10570948 - 财政年份:2022
- 资助金额:
$ 20.06万 - 项目类别:
Advanced Treatment Endpoint Assessment in MR-guided Focused Ultrasound
MR 引导聚焦超声的高级治疗终点评估
- 批准号:
10115726 - 财政年份:2020
- 资助金额:
$ 20.06万 - 项目类别:
相似海外基金
Nonlinear Acoustics for the conditioning monitoring of Aerospace structures (NACMAS)
用于航空航天结构调节监测的非线性声学 (NACMAS)
- 批准号:
10078324 - 财政年份:2023
- 资助金额:
$ 20.06万 - 项目类别:
BEIS-Funded Programmes
ORCC: Marine predator and prey response to climate change: Synthesis of Acoustics, Physiology, Prey, and Habitat In a Rapidly changing Environment (SAPPHIRE)
ORCC:海洋捕食者和猎物对气候变化的反应:快速变化环境中声学、生理学、猎物和栖息地的综合(蓝宝石)
- 批准号:
2308300 - 财政年份:2023
- 资助金额:
$ 20.06万 - 项目类别:
Continuing Grant
University of Salford (The) and KP Acoustics Group Limited KTP 22_23 R1
索尔福德大学 (The) 和 KP Acoustics Group Limited KTP 22_23 R1
- 批准号:
10033989 - 财政年份:2023
- 资助金额:
$ 20.06万 - 项目类别:
Knowledge Transfer Partnership
User-controllable and Physics-informed Neural Acoustics Fields for Multichannel Audio Rendering and Analysis in Mixed Reality Application
用于混合现实应用中多通道音频渲染和分析的用户可控且基于物理的神经声学场
- 批准号:
23K16913 - 财政年份:2023
- 资助金额:
$ 20.06万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Combined radiation acoustics and ultrasound imaging for real-time guidance in radiotherapy
结合辐射声学和超声成像,用于放射治疗的实时指导
- 批准号:
10582051 - 财政年份:2023
- 资助金额:
$ 20.06万 - 项目类别:
Comprehensive assessment of speech physiology and acoustics in Parkinson's disease progression
帕金森病进展中言语生理学和声学的综合评估
- 批准号:
10602958 - 财政年份:2023
- 资助金额:
$ 20.06万 - 项目类别:
The acoustics of climate change - long-term observations in the arctic oceans
气候变化的声学——北冰洋的长期观测
- 批准号:
2889921 - 财政年份:2023
- 资助金额:
$ 20.06万 - 项目类别:
Studentship
Collaborative Research: Estimating Articulatory Constriction Place and Timing from Speech Acoustics
合作研究:从语音声学估计发音收缩位置和时间
- 批准号:
2343847 - 财政年份:2023
- 资助金额:
$ 20.06万 - 项目类别:
Standard Grant
Collaborative Research: Estimating Articulatory Constriction Place and Timing from Speech Acoustics
合作研究:从语音声学估计发音收缩位置和时间
- 批准号:
2141275 - 财政年份:2022
- 资助金额:
$ 20.06万 - 项目类别:
Standard Grant
Flow Physics and Vortex-Induced Acoustics in Bio-Inspired Collective Locomotion
仿生集体运动中的流动物理学和涡激声学
- 批准号:
DGECR-2022-00019 - 财政年份:2022
- 资助金额:
$ 20.06万 - 项目类别:
Discovery Launch Supplement