Real-time monitoring and treatment evaluation of MR guided focal ultrasound-mediated non-thermal ablation of brain tumors
磁共振引导聚焦超声介导脑肿瘤非热消融的实时监测和治疗评估
基本信息
- 批准号:10511064
- 负责人:
- 金额:$ 22.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AcousticsAcuteAftercareAnimal ModelBiological MarkersBrainBrain NeoplasmsCancer PatientCause of DeathCentral Nervous System NeoplasmsClinicClinicalClinical TrialsDataDetectionDiagnosisDiffusionEmerging TechnologiesEnsureErythrocytesEvaluationExtravasationFocused UltrasoundFocused Ultrasound TherapyGoalsHistologyHistopathologyHourImageIschemic StrokeKnowledgeLesionMagnetic ResonanceMagnetic Resonance ImagingMalignant NeoplasmsMalignant neoplasm of brainMeasuresMediatingMethodsMicrobubblesModalityModelingMonitorMorbidity - disease rateMovement DisordersOperative Surgical ProceduresPatientsPersonsPhasePhysiologic pulsePredispositionPrimary Brain NeoplasmsProcessQuality of lifeRadiation Dose UnitRadiation therapyRattusResearchScalp structureSpinal NeoplasmsStructureSurvival RateSystemThermal Ablation TherapyThermometryTimeTissuesToxic effectTranslationsUltrasonicsUnited Statesbasebonebrain tissuechemotherapycost effectivecraniumimaging approachimaging biomarkerimaging modalityimprovedin vivoinnovationinterestmagnetic resonance imaging biomarkernervous system disordernovelovertreatmentpre-clinicalpressurepsychologicreal time monitoringside effecttooltreatment effecttumorultrasound
项目摘要
There is a clear and urgent unmet clinical need for non-invasive, non-ionizing and non-chemo-toxic
treatment options for patients with brain tumors. The long-term goal of this proposal is to develop non-
thermal ablation (NTA) using phase shift microbubble-aided Magnetic Resonance guided Focused
Ultrasound (MRgFUS) into a new non-invasive treatment option that will provide brain cancer patients with
increased survival rates and decreased side effects. The overall objective of this application is to (i) develop
novel Magnetic Resonance Imaging (MRI) based methods for real-time monitoring and guidance of the non-
thermal ablation process; and (ii) adapt a recently developed and validated voxel-wise in vivo MRI to
histopathology registration pipeline to brains, and use it to develop and verify imaging biomarkers which can
acutely predict long-term tissue non-viability. The rationale for this project is that a means for non-invasive
real-time monitoring which directly image the effect of the treatment on the tissue of interest, together with a
thorough understanding of non-thermally induced lesion progression and prediction of long-term tissue
nonviability are necessary to facilitate safe and timely translation of non-thermal MRgFUS ablation of brain
tumors to large animal models and ultimately to the clinic. We will achieve this in two specific aims; 1)
Develop innovative MRI-based approaches for direct real-time monitoring of tissue of interest during non-
thermal ablation, and evaluate them based on real-time applicability and sensitivity to acutely detect lesion
formation in a rat brain tumor model; 2) Adapt an MRI to histopathology registration pipeline and use it to
gain understanding about lesion progression and to develop imaging biomarkers for acute prediction of
long-term tissue non-viability. The research proposed in this application is innovative, in the applicant’s
opinion, because it will develop sensitive approaches for real-time monitoring of the lesion progression of
FUS non-thermal ablation, and will use a MRI-to-histology registration pipeline to develop understanding
about lesion progression and develop imaging biomarkers to predict tissue nonviability. Ultimately, this novel
non-invasive treatment modality has the potential to provide the tens of thousands of patients diagnosed
with brain tumors each year with a safe an efficient treatment option.
对非侵入性、非电离性和无化学毒性的临床需求明确而迫切
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Henrik Carl Axel Odeen其他文献
Henrik Carl Axel Odeen的其他文献
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{{ truncateString('Henrik Carl Axel Odeen', 18)}}的其他基金
Real-time monitoring and treatment evaluation of MR guided focal ultrasound-mediated non-thermal ablation of brain tumors
磁共振引导聚焦超声介导脑肿瘤非热消融的实时监测和治疗评估
- 批准号:
10659248 - 财政年份:2022
- 资助金额:
$ 22.01万 - 项目类别:
Feasibility of transcranial histotripsy for pediatric neuro-oncology applications using a hemispherical transducer
使用半球形换能器进行经颅组织解剖用于儿科神经肿瘤学应用的可行性
- 批准号:
10570948 - 财政年份:2022
- 资助金额:
$ 22.01万 - 项目类别:
Feasibility of transcranial histotripsy for pediatric neuro-oncology applications using a hemispherical transducer
使用半球形换能器进行经颅组织解剖用于儿科神经肿瘤学应用的可行性
- 批准号:
10433621 - 财政年份:2022
- 资助金额:
$ 22.01万 - 项目类别:
Advanced Treatment Endpoint Assessment in MR-guided Focused Ultrasound
MR 引导聚焦超声的高级治疗终点评估
- 批准号:
10115726 - 财政年份:2020
- 资助金额:
$ 22.01万 - 项目类别:
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