Reinforcing dental adhesives with monomers capable dynamic rearrangement and self-recovery

项目摘要 获奖申请者的长期目标是建立一个有竞争力的、独立资助的研究项目。 这将开发出坚固的材料来应对医疗挑战。这一目标将通过执行来实现 有组织的、全面的和综合的职业发展计划、有效的指导和有吸引力的 创新研究项目。拟议的研究项目将研究自腐蚀中的相分离。 并探索在胶粘剂树脂中使用具有适应性的单体，以提高动态氢键的性能 整体粘接性能。该项目的三个目标将解决相分离的假设 在粘合聚合过程中，形成杂化层的弱化区域，必须对其进行增强以确保 坚固的粘接性能。为此，研究项目的第一个目标是研究 建立自酸蚀粘结剂的模型，并确定所产生的异质微区的组成和形态 这是在聚合过程中产生的。研究项目的第二个目标是开发一系列甲基丙烯酸酯 带有两个不同氢键基团的单体(儿茶酚和缩脲-4[1H]-嘧啶酮- UPY)，并确定它们在胶粘剂树脂中的性能以及在响应施加量时的重排效果 压力。为Caroline Szczepanski博士提出的职业发展建议包括 评估预期聚合材料的性能、生物兼容性和稳定性的实验方案 用于口腔护理。此外，广泛的技能培训是管理独立职业和 资助的研究实验室(例如，赠款、实验室管理)将得到解决。这些目标是 辅以导师的选择和机构环境，这些都将有助于提供 申请人制定成功的研究项目并取得成功所需的技能和指导 独立调查员。导师团队将由Ana Bedran-Russo教授(伊利诺伊大学芝加哥分校)组成 -UIC)、Christina Chan教授(密歇根州立大学-MSU)和Marco Bottino教授(密歇根大学)。 教授们。Bedran-Russo和Bottino将在材料分析方面提供关键的指导和培训 在模拟口腔环境中的表现(例如，微拉伸粘结测试)以及牙本质的使用 标本以评估粘接效果。因为这两位教授。Bedran-Russo和Bottino隶属于学校 对于牙科医学，他们还将为Szczepanski博士提供参加研究研讨会、会见 其他研究人员，以及这一新研究领域内的网络。陈教授将特别提供指导 专注于资质以及在密歇根州立大学获得连任和终身教职的道路上。此外 对于这些导师来说，Szczepanski博士的职业发展计划包括关于资助者精神的研讨会， 在整个获奖期内，将进行负责任的研究，并进行指导。团结在一起， 拟议的研究和职业发展计划将以申请人在聚合物科学方面的专业知识为基础 将自己定位为NIDCR和NIH相关研究的重要贡献者。

Project Summary The long-term goal of the award applicant is to establish a competitive, independently funded research program that develops robust materials to address healthcare challenges. This goal will be realized through the execution of an organized, thorough, and integrated career development plan, effective mentorship, and an engaging and innovative research project. The proposed research project will investigate phase separation in self-etch adhesive resins and explore the use of monomers capable of adaptable, dynamic hydrogen bonding to improve overall adhesive performance. The three aims of this project will address the hypothesis that phase separation during adhesive polymerization forms weakened domains of the hybrid layer, which must be reinforced to ensure robust adhesive performance. To this end, the first goal of the research project is to study phase separation in model self-etch adhesives and to ascertain the resulting composition and morphology of heterogeneous domains that result during polymerization. The second goal of the research project is to develop a series of methacrylate monomers decorated with two different hydrogen bonding groups (catechol, and ureido-4[1H]-pyrimidinone – UPy) and ascertain their performance in adhesive resins and efficacy at rearranging in response to applied stresses. The career development proposed for Dr. Caroline Szczepanski includes training in relevant experimental protocols to assess the performance, biocompatibility, and stability of polymeric materials intended for oral care. Additionally, broad training in skills necessary for the management of an independent career and funded research laboratory (e.g. grantsmanship, lab management) will be addressed. These goals are complemented by the choice of mentors and the institutional environment which will all assist in providing the skills and guidance needed by the applicant to develop a successful research program and succeed as an independent investigator. The mentor team will consist of Prof. Ana Bedran-Russo (University of Illinois Chicago – UIC), Prof. Christina Chan (Michigan State University - MSU) and Prof. Marco Bottino (University of Michigan). Profs. Bedran-Russo and Bottino will provide critical guidance and training in the analysis of material performance in simulated oral environments (e.g. micro-tensile bond testing), as well as the use of dentin specimens to assess adhesive efficacy. Since both Profs. Bedran-Russo and Bottino are affiliated with schools of dental medicine, they will also provide Dr. Szczepanski with opportunities to attend research seminars, meet fellow researchers, and network within this new field of research. Prof. Chan will provide mentorship particularly focused on grantsmanship as well as navigating the path towards reappointment and tenure at MSU. In addition to these mentors, Dr. Szczepanski’s career development plan includes seminars in the grantsmanship, responsible conduct of research, and mentorship will be pursued throughout the award period. Together, the proposed research and career development plan will build upon the applicant’s expertise in polymer science to situate themselves as a significant contributor to NIDCR and NIH relevant research.