Reinforcing dental adhesives with monomers capable dynamic rearrangement and self-recovery

使用具有动态重排和自我恢复能力的单体增强牙科粘合剂

• 批准号: 10625355
• 负责人: Caroline Rose Szczepanski
• 金额: $ 15.68万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625355
• 关键词: 3-Dimensional; Acceleration; Address; Adhesives; Amalgam; Appearance; Appointment; Award; Bacteria; Behavior; Biocompatible Materials; Biological; Bone Tissue; Catechols; Categories; Chicago; Clinical; Complement; Complex; Dental Materials; Dental Schools; Dentin; Development; Development Plans; Ensure; Environment; Esthetics; Exposure to; Failure; Fatigue; Formulation; Funding; Goals; Growth; Healthcare; Heterogeneity; Hybrids; Hydrogen Bonding; Illinois; Infiltration; Institution; Investigation; Laboratory Research; Longevity; Mechanical Stress; Mechanics; Medicine; Mentors; Mentorship; Methacrylates; Michigan; Modeling; Morphology; National Institute of Dental and Craniofacial Research; Oral; Patient Care; Patients; Performance; Phase; Plant Resins; Polymers; Positioning Attribute; Postdoctoral Fellow; Predisposition; Protocols documentation; Pyrimidinones; Recovery; Relaxation; Research; Research Personnel; Research Project Grants; Route; Science; Series; Specimen; Stress; Structure; System; Testing; Training; United States; United States National Institutes of Health; Universities; Water; Work; adhesive polymer; analog; biomaterial compatibility; career; career development; chemical group; composite restoration; cost; dental adhesive; design; driving force; efficacy evaluation; improved; innovation; mechanical properties; monomer; novel; oral care; photopolymerization; polymerization; programs; research and development; response; responsible research conduct; restoration; restorative dentistry; restorative material; skills; success; uptake

Project Summary The long-term goal of the award applicant is to establish a competitive, independently funded research program that develops robust materials to address healthcare challenges. This goal will be realized through the execution of an organized, thorough, and integrated career development plan, effective mentorship, and an engaging and innovative research project. The proposed research project will investigate phase separation in self-etch adhesive resins and explore the use of monomers capable of adaptable, dynamic hydrogen bonding to improve overall adhesive performance. The three aims of this project will address the hypothesis that phase separation during adhesive polymerization forms weakened domains of the hybrid layer, which must be reinforced to ensure robust adhesive performance. To this end, the first goal of the research project is to study phase separation in model self-etch adhesives and to ascertain the resulting composition and morphology of heterogeneous domains that result during polymerization. The second goal of the research project is to develop a series of methacrylate monomers decorated with two different hydrogen bonding groups (catechol, and ureido-4[1H]-pyrimidinone – UPy) and ascertain their performance in adhesive resins and efficacy at rearranging in response to applied stresses. The career development proposed for Dr. Caroline Szczepanski includes training in relevant experimental protocols to assess the performance, biocompatibility, and stability of polymeric materials intended for oral care. Additionally, broad training in skills necessary for the management of an independent career and funded research laboratory (e.g. grantsmanship, lab management) will be addressed. These goals are complemented by the choice of mentors and the institutional environment which will all assist in providing the skills and guidance needed by the applicant to develop a successful research program and succeed as an independent investigator. The mentor team will consist of Prof. Ana Bedran-Russo (University of Illinois Chicago – UIC), Prof. Christina Chan (Michigan State University - MSU) and Prof. Marco Bottino (University of Michigan). Profs. Bedran-Russo and Bottino will provide critical guidance and training in the analysis of material performance in simulated oral environments (e.g. micro-tensile bond testing), as well as the use of dentin specimens to assess adhesive efficacy. Since both Profs. Bedran-Russo and Bottino are affiliated with schools of dental medicine, they will also provide Dr. Szczepanski with opportunities to attend research seminars, meet fellow researchers, and network within this new field of research. Prof. Chan will provide mentorship particularly focused on grantsmanship as well as navigating the path towards reappointment and tenure at MSU. In addition to these mentors, Dr. Szczepanski’s career development plan includes seminars in the grantsmanship, responsible conduct of research, and mentorship will be pursued throughout the award period. Together, the proposed research and career development plan will build upon the applicant’s expertise in polymer science to situate themselves as a significant contributor to NIDCR and NIH relevant research.

项目摘要 该奖项申请人的长期目标是建立一个有竞争力的，独立资助的研究计划 该公司致力于开发坚固的材料，以应对医疗保健挑战。这一目标将通过执行来实现 一个有组织的，全面的，综合的职业发展计划，有效的指导，以及一个有吸引力的， 创新研究项目。拟议的研究项目将调查自蚀刻中的相分离 粘合剂树脂和探索使用单体能够适应，动态氢键，以提高 整体粘合性能。该项目的三个目标将解决相分离的假设 在粘合剂聚合过程中形成混合层的弱化区域， 强大的粘合性能。为此，本研究项目的第一个目标是研究相分离， 模型自蚀刻粘合剂并确定由此产生的非均质域的组成和形态 这是在聚合过程中产生的。该研究项目的第二个目标是开发一系列甲基丙烯酸酯 用两个不同的氢键基团（邻苯二酚和脲基-4 [1H]-嘧啶酮- UPy），并确定它们在粘合剂树脂中的性能以及响应于所施加的压力而重新排列的功效。 压力Caroline Szczepanski博士的职业发展包括相关培训 评估预期聚合物材料性能、生物相容性和稳定性的实验方案 口腔护理此外，广泛的技能培训，必要的管理一个独立的职业生涯， 将讨论受资助的研究实验室（例如，实验室管理）。这些目标是 辅之以导师的选择和体制环境，这一切都将有助于提供 技能和指导所需的申请人制定一个成功的研究计划，并成功地作为一个 独立调查员导师团队将由Ana Bedran-Russo教授（伊利诺伊大学芝加哥分校 - UIC）、Christina Chan教授（密歇根州立大学- MSU）和Marco Bottino教授（密歇根大学）。 教授Bedran-Russo和Bottino将提供材料分析方面的关键指导和培训 在模拟口腔环境中的性能（例如，微拉伸粘合测试），以及牙本质的使用 样本以评估粘合剂功效。由于两位教授Bedran-Russo和Bottino与学校有联系 他们还将为Szczepanski博士提供参加研究研讨会， 研究人员和网络在这个新的研究领域。陈教授将特别提供导师服务 专注于granitarian以及导航的道路上重新任命和终身在密歇根州立大学。此外 对于这些导师，Szczepanski博士的职业发展计划包括在格兰披治大学举办研讨会， 负责的研究行为，并指导将在整个奖励期间进行。统称 拟议的研究和职业发展计划将建立在申请人在聚合物科学的专业知识， 作为NIDCR和NIH相关研究的重要贡献者。