Muscle power training to improve depression and walking post-stroke

肌肉力量训练可改善抑郁症和中风后行走

• 批准号: 10433884
• 负责人: Chris Gregory
• 金额: $ 42.77万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-13 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10433884
• 关键词: Address; Affect; Age; Clinical; Clinical Treatment; Clinical Trials; Data; Depressed mood; Development; Disease remission; Dose; Educational Intervention; Foundations; Functional disorder; Gender; Goals; Hamilton Rating Scale for Depression; Individual; Intervention; Joints; Literature; Lower Extremity; Measures; Mental Depression; Muscle; Muscle Weakness; Muscle function; Neuronal Plasticity; Outcome; Persons; Pharmacological Treatment; Power Walking; Prevalence; Randomized; Rehabilitation therapy; Reporting; Severities; Stretching; Stroke; Symptoms; Techniques; Training; Training Programs; Walking; Work; base; chronic stroke; cohort; cost; depressive symptoms; design; effective therapy; exercise training; experimental study; follow-up; functional gain; functional improvement; functional outcomes; improved; innovation; muscle strength; negative affect; neuropsychiatry; non-drug; noninvasive brain stimulation; novel; post stroke; post stroke depression; rate of change; rehabilitation strategy; response; side effect; strength training; stroke recovery; stroke survivor; therapeutic effectiveness; therapy design; therapy development; treatment guidelines; treatment response; walking speed

Abstract Depression is the most common neuropsychiatric manifestation following stroke and current treatments are largely ineffective. Depression has both direct and indirect effects on response to rehabilitation, thus subjects with post-stroke depression (PSD) are routinely excluded from clinical trials and treatment options are extremely limited. We propose to determine the impact of a novel, high-intensity resistance training program, Post-stroke Optimization of Walking using Explosive Resistance (POWER) training, on post-stroke depressive symptoms. Further, we will determine if depression limits training-induced improvements in muscular and locomotor function. This project is based on the premise that depression negatively affects the potential for neuroplastic changes to occur in response to treatment such that rehabilitation may not produce the same adaptations that it does in non-depressed individuals. We propose that effective treatment for PSD would result in a virtuous cycle where reducing depression enhances neuroplastic changes, thereby facilitating functional gains. That is, effectively treating depression will make the individual better able to recover from stroke. Furthermore, in addition to its beneficial effects on depression, POWER training is known to improve post-stroke walking, thus providing an attractive option for treating depression as well as an established vehicle to study the effects of PSD on response to rehabilitation. The experiments proposed as part of this project are designed to address critical questions related to 1) the effects of POWER training on depressive symptoms; 2) the potential for PSD to limit improvements following training; and 3) the interaction between improvements in depression and increases in walking function. Successful completion of this project will provide a foundation for larger scale trials to determine dosing parameters as well as establish therapeutic effectiveness of POWER training on post-stroke depression as well as identify the mechanisms that may be responsible for the changes that occur in response to treatment.

摘要

项目成果

Associations Between Doing Planned Exercise and Probable Major Depressive Disorder in Individuals Following Spinal Cord Injury.

脊髓损伤后进行有计划的锻炼与可能患重度抑郁症之间的关联。

• DOI: 10.1310/sci2601-11
• 发表时间: 2020
• 期刊: Topics in spinal cord injury rehabilitation
• 影响因子: 2.9
• 作者: VanDerwerker,CatherineJefferson;Cao,Yue;Gregory,ChrisM;Krause,JamesS
• 通讯作者: Krause,JamesS

Evaluating a novel MR-compatible foot pedal device for unipedal and bipedal motion: Test-retest reliability of evoked brain activity.

• DOI: 10.1002/hbm.25209
• 发表时间: 2021-01
• 期刊: Human brain mapping
• 影响因子: 4.8
• 作者: Doolittle JD;Downey RJ;Imperatore JP;Dowdle LT;Lench DH;McLeod J;McCalley DM;Gregory CM;Hanlon CA
• 通讯作者: Hanlon CA

The role of exercise in the treatment of depression: biological underpinnings and clinical outcomes.

• DOI: 10.1038/s41380-022-01819-w
• 发表时间: 2023-01
• 期刊: MOLECULAR PSYCHIATRY
• 影响因子: 11
• 作者: Ross, Ryan E.;VanDerwerker, Catherine J.;Saladin, Michael E.;Gregory, Chris M.
• 通讯作者: Gregory, Chris M.

Effect of power training on rate of torque development and spatiotemporal gait parameters post stroke.

力量训练对中风后扭矩发展速率和时空步态参数的影响。

• DOI: 10.1016/j.clinbiomech.2023.105953
• 发表时间: 2023
• 期刊: Clinical biomechanics (Bristol, Avon)
• 作者: Williams,EwanR;VanDerwerker,CatherineJ;Ross,RyanE;Evans,EllenM;Gregory,ChrisM
• 通讯作者: Gregory,ChrisM