Evaluating a novel MR-compatible foot pedal device for unipedal and bipedal motion: Test-retest reliability of evoked brain activity.
Evaluating a novel MR-compatible foot pedal device for unipedal and bipedal motion: Test-retest reliability of evoked brain activity.
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DOI：
10.1002/hbm.25209
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发表时间：
2021-01
影响因子：
4.8
通讯作者：
Hanlon CA
中科院分区：
文献类型：
--
作者：
Doolittle JD;Downey RJ;Imperatore JP;Dowdle LT;Lench DH;McLeod J;McCalley DM;Gregory CM;Hanlon CA
本研究的目的是开发和评估一种新的、开源的MR兼容设备，该设备能够评估单足和双足下肢运动，头部运动最小，测试重测可靠性高。为了评估原型，20名健康成年人参加了两次磁共振成像（MRI）访问，间隔2-6个月，其中他们分别用左脚、右脚和交替的脚进行了视觉引导的背屈/足底弯曲任务。依赖测量包括：运动网络中的诱发血氧水平依赖（BOLD）信号，与背屈/足底屈相关的头部运动，这些测量的重测可靠性。与休息相比，左、右单脚运动导致左、右初级运动皮层内侧和同侧小脑的BOLD信号显著增加（FWE校正，p < 0.001）。平均头部运动为0.10±0.02 mm。功能性MRI数据（类内相关系数[ICC]: >0.75）和踝关节角位移（ICC: 0.842）的重测信度较高。这种双足装置可以在交替跖屈和背屈时有效地隔离运动网络的活动，同时提供高测试-重测试可靠性。最终，这些数据和开源的构建指令将为对评估下肢运动导致的脑功能感兴趣的研究人员提供一种新的、经济的工具。我们提出了一种新的、开源的MR兼容设备，能够以最小的头部运动和高测试重测可靠性评估单足和双足下肢运动。这种双足装置可以在交替跖屈和背屈时有效地隔离运动网络的活动。这些数据和开源的构建指南将为对评估下肢运动导致的脑功能感兴趣的研究人员提供一种新的、经济的工具。
The purpose of this study was to develop and evaluate a new, open‐source MR‐compatible device capable of assessing unipedal and bipedal lower extremity movement with minimal head motion and high test–retest reliability. To evaluate the prototype, 20 healthy adults participated in two magnetic resonance imaging (MRI) visits, separated by 2–6 months, in which they performed a visually guided dorsiflexion/plantar flexion task with their left foot, right foot, and alternating feet. Dependent measures included: evoked blood oxygen level‐dependent (BOLD) signal in the motor network, head movement associated with dorsiflexion/plantar flexion, the test–retest reliability of these measurements. Left and right unipedal movement led to a significant increase in BOLD signal compared to rest in the medial portion of the right and left primary motor cortex (respectively), and the ipsilateral cerebellum (FWE corrected, p < .001). Average head motion was 0.10 ± 0.02 mm. The test–retest reliability was high for the functional MRI data (intraclass correlation coefficients [ICCs]: >0.75) and the angular displacement of the ankle joint (ICC: 0.842). This bipedal device can robustly isolate activity in the motor network during alternating plantarflexion and dorsiflexion with minimal head movement, while providing high test–retest reliability. Ultimately, these data and open‐source building instructions will provide a new, economical tool for investigators interested in evaluating brain function resulting from lower extremity movement. We present a new, open‐source MR‐compatible device capable of assessing unipedal and bipedal lower extremity movement with minimal head motion and high test–retest reliability. This bipedal device can robustly isolate activity in the motor network during alternating plantarflexion and dorsiflexion. These data and open‐source building instructions will provide a new, economical tool for investigators interested in evaluating brain function resulting from lower extremity movement.
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