Skeletal Muscle Plasticity As An Indicator of Functional Performance Post-Stroke

骨骼肌可塑性作为中风后功能表现的指标

• 批准号: 8990852
• 负责人: Chris Gregory
• 金额: --
• 依托单位: RALPH H JOHNSON VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-10-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8990852
• 关键词: 3-Dimensional; Address; Affect; Area; Attenuated; Belief; Bioenergetics; Biomechanics; Biomedical Research; Body Weight; Characteristics; Chronic; Clinical; Communities; Complex; Data; Disease; Educational Intervention; Effectiveness; Elements; Equilibrium; Equipment; Exercise; Failure; Functional disorder; Funding; Future; Gait; Gait speed; Generations; Goals; Health; Image; Impairment; Individual; Intervention; Joints; Leg; Level of Evidence; Life; Limb structure; Locomotor Recovery; Locomotor training; Lower Extremity; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Measures; Morphology; Motor; Muscle; Muscle Weakness; Muscle function; Neuraxis; Paresis; Performance; Peripheral; Persons; Physiological; Population; Property; Recovery of Function; Rehabilitation Outcome; Rehabilitation therapy; Reporting; Residual state; Rest; Side; Skeletal Muscle; Speed; Stroke; Support System; Survivors; Task Performances; Techniques; Therapeutic; Therapeutic Intervention; Time; Training; Treatment Efficacy; United States; Walking; Work; aging population; base; cohort; design; disability; fall risk; functional disability; functional improvement; hemiparesis; improved; in vivo; independent ambulation; innovation; inorganic phosphate; kinematics; leg paresis; motor control; muscle strength; novel; post stroke; prevent; relating to nervous system; remediation; response; skeletal muscle plasticity; strength training; stroke hemiparesis; stroke survivor; walking speed

DESCRIPTION (provided by applicant): A primary impairment associated with post-stroke hemiparesis is the failure to make rapid graded adjustment of muscle force (i.e. muscle power) within the context of purposeful complex synergies (e.g., coordination during walking). Not surprisingly, the impact of stroke on walking is significant, with less than 50% of survivors progressing to independent community ambulation. Even among those who achieve independent ambulation, significant residual deficits persist in balance and gait speed, with ~75% of persons post-stroke reporting limitations in mobility related to walking. Muscle weakness is the most prominent motor consequence among the nearly 6 million survivors of stroke living in the United States and the strongest predictor of functional disability in this large clinical cohort. To date, the physiological mechanisms that contribute to muscle dysfunction in hemiparetic subjects are largely unstudied. Moreover, evidence regarding the efficacy of interventions aimed at attenuating impaired muscle function and the ensuing functional consequences in the post-stroke population is equivocal and viable therapeutic options to remediate hemiparetic muscle weakness remain among the most pressing challenges for biomedical research. We propose that impaired muscle power (the product of muscle strength and velocity) generation is causal of functional (walking) disability post-stroke. In addition, coordination deficits are also critical determinants of functional performance. We have developed a comprehensive theoretical framework that defines and measures the factors underlying disordered muscle function and coordination and will apply this framework to Post-stroke Optimization of Walking using Explosive Resistance (POWER) training. Our goals over the four year funding period are to 1) quantify neural and muscular adaptations that contribute to impaired muscle power generation post-stroke; 2) assess effects of POWER training on neural and muscular adaptations in paretic and non-paretic muscle; and 3) determine the relationship between changes in neural and muscular adaptations following POWER training and locomotor improvements. Innovative aspects of the proposed work include the novel training intervention; the advanced magnetic resonance assessments; as well as the unique measure of the coordination that we propose. It is our belief that: a) neural and muscular adaptations following stroke are associated with impaired muscle power generation as well as locomotor ability, b) POWER training attenuates functional deficits by addressing the underlying neural and muscular elements and c) functional improvements following training are predicated on improving the most prominent neural and muscular contributors to muscle power generation. If correct, the data generated will provide an entirely new level of evidence regarding the effectiveness of this novel intervention strategy on improving functional performance as well as the importance of peripheral muscle properties as predictors of locomotor ability post-stroke.

描述（由申请人提供）：