Integrated Training in Reproductive Sciences

该培训计划为医生和科学家在生殖领域的调查职业做好准备。 生物学在其35年的历史中，培训补助金已经支持了100多名博士后研究员，他们 在学术界和工业界取得了成功。该方案是多方面的，基础广泛。 研究培训由生殖科学中心（CRS）的17名成员提供， 8个部门的职位。该学院拥有广泛的科学专业知识和直接研究 生殖生物学专业，包括：胚胎移植胚胎发育和干细胞生物学， 细胞发育，减数分裂，卵泡成熟，激素作用机制，分子遗传学，类固醇 生物合成和作用，子宫内膜和胎盘功能，正常和异常的内分泌调节 生殖功能，母胎界面的免疫功能，PCOS的基础和临床研究， 子宫内膜异位症先兆子痫和早产可用的技术包括：人类和小鼠 胚胎学，胚胎和诱导多能干细胞，转基因小鼠，果蝇干细胞和生殖细胞 发展，减数分裂的酵母模型，人类遗传学和基因组学，最先进的DNA和RNA 测序、蛋白质/核酸相互作用技术、单细胞RNA测序、最新技术水平 技术探测表观遗传标记和染色质结构和非编码RNA，微阵列和 蛋白质组学，生物信息学，蛋白质和小分子的质谱分析，尖端 显微镜和成像技术，体外受精，整体动物生理学，前瞻性临床 调查在正式申请CRS后，学员由招生委员会挑选。 博士后培训将提供给相关学科的博士研究员和临床培训的医学博士科学家 接受过专业训练除了研究工作外，受训人员还参加规定的学术课程， 研讨会、期刊俱乐部、会议和关于负责任的研究行为的研讨会。学员学习 设计和执行基础和转化研究项目，分析数据和撰写手稿， 著名的同行评审期刊。受训人员准备并提交校外资助的赠款申请， 目前在生殖生物学研讨会，并学习如何指导暑期学生在实验室工作， 为他们独立的学术生涯做准备。通过指导确保受训人员的学术发展 委员会通过个人发展计划;跟踪受训人员和培训计划的成功 通过对校友的调查。该计划的优势包括1）。不同的技能和利益的 教师，2.）教师的互动性（3）。我们的大量实验室和核心设施资源4.）的 在生殖，发育，内分泌学，细胞生物学，遗传学和 在UCSF的相关领域和5。对科学行为最高标准的承诺。

This Training Program prepares physicians and scientists for investigative careers in reproductive biology. During its 35 year history, the training grant has supported over 100 postdoctoral fellows who have gone on to successful careers in academia and industry. The program is multifaceted and broadly based. Research training is provided by 17 members of the Center for Reproductive Sciences (CRS) who hold faculty positions in 8 departments. The Faculty have a broad range of scientific expertise and direct research programs in reproductive biology, including: peimplantation embryo development and stem cell biology, germ cell development, meiosis, follicular maturation, mechanisms of hormone action; molecular genetics, steroid biosynthesis and action, endometrial and placental function, endocrine regulation of normal and abnormal reproductive function, immune function in the maternal/fetal interface, basic and clinical studies of PCOS, endometriosis, preeclampsia, and preterm birth. Technologies available include: human and mouse embryology, embryonic and induced pluripotent stem cells, transgenic mice, Drosophila stem and germ cell development, yeast models of meiosis, human genetics and genomics, state-of-the-art DNA and RNA sequencing, protein/nucleic acid interaction technologies, single cell RNA sequencing, state-of-the-art techonologies probing epigenetic marks and chromatin structure and non coding RNAs, microarrays and proteomics, bioinformatics, mass spectrometric analysis of proteins and small molecules, cutting edge microscopy and imaging technologies, in vitro fertilization, whole animal physiology, prospective clinical investigation. Following formal application to the CRS, trainees are selected by an Admissions Committee. Postdoctoral training will be offered to PhD fellows in related disciplines, and to clinically trained MD scientists with prior specialty training. In addition to their research work, trainees take prescribed academic courses, seminars, journal clubs, conferences, and seminars on the responsible conduct of research. Trainees learn to design and execute basic and translational research projects, analyze data and write manuscripts for prominent peer-reviewed journals. Trainees prepare and submit grant applications for extra-mural funding, present seminars in reproductive biology, and learn how to mentor summer students working in the lab, preparing them for independent academic careers. Trainee academic development is assured by mentoring committees through individual development plans; success of trainees and the training program is tracked through surveys of alumni. The strengths of the program include 1.) the diverse skills and interests of the faculty, 2.) the interactiveness of the faculty 3.) our substantial laboratory and core facility resources 4.) the outstanding environment for research in reproduction, development, endocrinology, cell biology, genetics and related areas at UCSF and 5.) the commitment to the highest standard of conduct in science.