Defining single-strand DNA break repair capacity in oocytes

定义卵母细胞中的单链 DNA 断裂修复能力

• 批准号: DE210100375
• 负责人: Dr Amy Winship
• 金额: $ 30.12万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE210100375
• 关键词: Defining; single; strand; DNA; break

This project aims to investigate fundamental biological mechanisms required for the production of high-quality oocytes, which fortify female fertility and the propagation of all sexually reproducing species. Exploiting unique mouse models, this study will define the importance of single strand DNA break repair capacity in oocytes for the first time, by outlining the role of single strand DNA repair proteins in maintaining genetic integrity of gametes throughout their lifespan. In doing so, the intended outcome of this project is to dramatically improve our understanding of quality control in the female germ line. This should provide significant benefits to Australia by positioning it as a world leader in the field of Reproductive Science.

该项目旨在研究生产高质量卵母细胞所需的基本生物学机制，这些卵母细胞可增强女性生育力和所有有性生殖物种的繁殖。利用独特的小鼠模型，这项研究将首次定义卵母细胞中单链DNA断裂修复能力的重要性，通过概述单链DNA修复蛋白在维持配子整个生命周期的遗传完整性中的作用。在这样做的时候，这个项目的预期结果是大大提高我们对女性生殖系质量控制的理解。这将使澳大利亚成为生殖科学领域的世界领导者，从而为澳大利亚带来重大利益。