Methods Core

方法核心

• 批准号: 10436045
• 负责人: Guy Brock
• 金额: $ 128.66万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10436045
• 关键词: Address; Applications Grants; Area; Artificial Intelligence; Behavior; Behavior Therapy; Big Data Methods; Capital; Childhood; Collaborations; Communities; Community Health; Data; Data Analyses; Data Collection; Data Element; Development; Elements; Ensure; Environment; Evaluation; Evidence based intervention; Fostering; Future; Generations; Goals; Grant; Growth and Development function; Health; Health system; Healthcare Systems; Information Technology; Infrastructure; Institutes; Intervention; Leadership; Mental Health; Mentors; Methodology; Methods; Modeling; Monitor; National Institute of Mental Health; Nerve; Ohio; Parents; Patient Representative; Patients; Pediatric Hospitals; Pilot Projects; Population; Population Intervention; Population Study; Positioning Attribute; Practical Robust Implementation and Sustainability Model; Predictive Analytics; Preparation; Prevention Research; Process; Productivity; Protocols documentation; Public Health; Qualitative Methods; Quality Control; Research; Research Design; Research Institute; Research Methodology; Research Personnel; Research Project Grants; Resources; Risk; Science; Services; Standardization; Statistical Models; Suicide; Suicide prevention; Testing; Universities; Work; Youth; acute care; career; clinical decision-making; data harmonization; data management; data sharing; data standards; design; digital health; health management; implementation framework; implementation science; implementation strategy; improved; innovation; interdisciplinary collaboration; medical specialties; model design; multidisciplinary; novel; outreach; population health; preventive intervention; program dissemination; programs; public health intervention; reducing suicide; social health determinants; social structure; student training; success; suicide rate; working group

ABSTRACT – METHODS CORE The ASPIRES Methods Core (MC) brings together investigators from diverse and complementary backgrounds to collectively address design, implementation, methodological, and technological challenges that impede progress toward effectively reducing the youth suicide rate. Our transdisciplinary team includes experts in study design methodology for behavioral and population interventions, predictive analytics to improve clinical decision making, development of digital health interventions, implementation science, qualitative methods, integration of multi-level data elements representative of patient and community health, and geospatial modeling of environment and social structure on population health. The MC capitalizes on substantial institutional infrastructure and intellectual capital at both The Abigail Wexner Research Institute (AWRI) at Nationwide Children’s Hospital (NCH) and The Ohio State University (OSU), and Co-Leaders Drs. Brock, McAlearney, and Lin have each led both specialized and multidisciplinary teams with broad impact spanning multiple areas of health. The MC will work with ASPIRES investigators to facilitate in a pediatric population 1) development and testing of novel and scalable interventions and research-generated resources with significant appeal for stakeholders; 2) rapid and widespread dissemination of new, effective practices; 3) continuous improvement of suicide prevention interventions delivered in real-world settings; 4) interdisciplinary team science to facilitate novel and convergent solutions to intractable suicide prevention challenges; and 5) training of students, fellows, early career, and advanced investigators from diverse backgrounds to increase the diversity of investigators conducting cutting-edge translational suicide prevention research. Our MC provides a methodological anchor connecting all ASPIRES projects, and our transdisciplinary team with substantial expertise, resources, and infrastructure at both NCH and OSU will ensure that all ASPIRES projects are conducted with scientific rigor and broadly disseminated. Creative partnerships with the Zero Suicide Institute and the OSU CCTS Pilot Project Program augment outreach, engagement, and dissemination. Methodological and technological advances from our MC provide innovative approaches to overcoming challenges facing behavioral interventions for reducing the youth suicide rate. Synergistic study design elements across ASPIRES projects provide unique opportunities to study implementation and efficacy aspects of suicide prevention interventions across primary, specialty, and acute care. Collectively, these developments support innovative and rigorous evaluation of ASPIRES interventions and provide the groundwork for further design and refinement of implementation strategies necessary to scale these interventions in future studies.

摘要——方法核心 ASPRES 方法核心 (MC) 汇集了来自不同且互补背景的研究人员 共同解决阻碍的设计、实施、方法和技术挑战 有效降低青少年自杀率取得进展。我们的跨学科团队包括以下领域的专家 研究行为和人群干预的设计方法，预测分析以改善临床 决策、数字健康干预措施的开发、实施科学、定性方法、 代表患者和社区健康以及地理空间的多级数据元素的集成 环境和社会结构对人口健康的影响建模。 MC充分利用了 阿比盖尔韦克斯纳研究所 (AWRI) 的机构基础设施和智力资本 全国儿童医院 (NCH) 和俄亥俄州立大学 (OSU) 以及联合领导者 Drs.布洛克， 麦卡利尼和林分别领导了具有广泛影响力的专业和多学科团队 多个健康领域。 MC 将与 ASPIRES 研究人员合作，为儿科人群提供便利 1) 开发和测试新颖且可扩展的干预措施以及研究产生的资源，具有重要意义 利益相关者的呼吁； 2) 快速、广泛传播新的、有效的做法； 3）连续 改善现实世界中的自杀预防干预措施； 4）跨学科团队 科学促进针对棘手的自杀预防挑战的新颖且一致的解决方案； 5）培训 来自不同背景的学生、研究员、早期职业生涯和高级研究人员，以提高 进行前沿转化性自杀预防研究的研究人员的多样性。我们的MC提供 连接所有 ASPIRE 项目的方法论支柱，以及我们的跨学科团队 NCH 和 OSU 的专业知识、资源和基础设施将确保所有 ASPIRES 项目 科学严谨地进行并广泛传播。与零自杀研究所的创造性合作伙伴关系 和 OSU CCTS 试点项目计划增强了外展、参与和传播。方法论 我们的 MC 和技术进步为克服面临的挑战提供了创新方法 降低青少年自杀率的行为干预。协同研究设计元素 ASPIRE 项目提供了独特的机会来研究自杀的实施和功效方面 初级、专科和急症护理的预防干预措施。总的来说，这些发展支持 对 ASPIRES 干预措施进行创新和严格的评估，并为进一步设计奠定基础 并完善必要的实施策略，以在未来的研究中扩展这些干预措施。