Methods Core

方法核心

• 批准号: 10436045
• 负责人: Guy Brock
• 金额: $ 128.66万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2027-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10436045
• 关键词: Address; Applications Grants; Area; Artificial Intelligence; Behavior; Behavior Therapy; Big Data Methods; Capital; Childhood; Collaborations; Communities; Community Health; Data; Data Analyses; Data Collection; Data Element; Development; Elements; Ensure; Environment; Evaluation; Evidence based intervention; Fostering; Future; Generations; Goals; Grant; Growth and Development function; Health; Health system; Healthcare Systems; Information Technology; Infrastructure; Institutes; Intervention; Leadership; Mental Health; Mentors; Methodology; Methods; Modeling; Monitor; National Institute of Mental Health; Nerve; Ohio; Parents; Patient Representative; Patients; Pediatric Hospitals; Pilot Projects; Population; Population Intervention; Population Study; Positioning Attribute; Practical Robust Implementation and Sustainability Model; Predictive Analytics; Preparation; Prevention Research; Process; Productivity; Protocols documentation; Public Health; Qualitative Methods; Quality Control; Research; Research Design; Research Institute; Research Methodology; Research Personnel; Research Project Grants; Resources; Risk; Science; Services; Standardization; Statistical Models; Suicide; Suicide prevention; Testing; Universities; Work; Youth; acute care; career; clinical decision-making; data harmonization; data management; data sharing; data standards; design; digital health; health management; implementation framework; implementation science; implementation strategy; improved; innovation; interdisciplinary collaboration; medical specialties; model design; multidisciplinary; novel; outreach; population health; preventive intervention; program dissemination; programs; public health intervention; reducing suicide; social health determinants; social structure; student training; success; suicide rate; working group

ABSTRACT – METHODS CORE The ASPIRES Methods Core (MC) brings together investigators from diverse and complementary backgrounds to collectively address design, implementation, methodological, and technological challenges that impede progress toward effectively reducing the youth suicide rate. Our transdisciplinary team includes experts in study design methodology for behavioral and population interventions, predictive analytics to improve clinical decision making, development of digital health interventions, implementation science, qualitative methods, integration of multi-level data elements representative of patient and community health, and geospatial modeling of environment and social structure on population health. The MC capitalizes on substantial institutional infrastructure and intellectual capital at both The Abigail Wexner Research Institute (AWRI) at Nationwide Children’s Hospital (NCH) and The Ohio State University (OSU), and Co-Leaders Drs. Brock, McAlearney, and Lin have each led both specialized and multidisciplinary teams with broad impact spanning multiple areas of health. The MC will work with ASPIRES investigators to facilitate in a pediatric population 1) development and testing of novel and scalable interventions and research-generated resources with significant appeal for stakeholders; 2) rapid and widespread dissemination of new, effective practices; 3) continuous improvement of suicide prevention interventions delivered in real-world settings; 4) interdisciplinary team science to facilitate novel and convergent solutions to intractable suicide prevention challenges; and 5) training of students, fellows, early career, and advanced investigators from diverse backgrounds to increase the diversity of investigators conducting cutting-edge translational suicide prevention research. Our MC provides a methodological anchor connecting all ASPIRES projects, and our transdisciplinary team with substantial expertise, resources, and infrastructure at both NCH and OSU will ensure that all ASPIRES projects are conducted with scientific rigor and broadly disseminated. Creative partnerships with the Zero Suicide Institute and the OSU CCTS Pilot Project Program augment outreach, engagement, and dissemination. Methodological and technological advances from our MC provide innovative approaches to overcoming challenges facing behavioral interventions for reducing the youth suicide rate. Synergistic study design elements across ASPIRES projects provide unique opportunities to study implementation and efficacy aspects of suicide prevention interventions across primary, specialty, and acute care. Collectively, these developments support innovative and rigorous evaluation of ASPIRES interventions and provide the groundwork for further design and refinement of implementation strategies necessary to scale these interventions in future studies.

摘要-方法核心 ASPIRES方法核心（MC）汇集了来自不同和互补背景的研究人员 共同应对阻碍我们实现目标的设计、实施、方法和技术挑战， 在有效降低青少年自杀率方面取得进展。我们的跨学科团队包括以下方面的专家： 行为和人口干预的研究设计方法、改善临床的预测分析 决策，数字健康干预措施的发展，实施科学，定性方法， 代表患者和社区健康的多层次数据元素的集成，以及地理空间 环境和社会结构对人群健康的影响模型。MC充分利用了 Abigail Wexner研究所（AWRI）的机构基础设施和知识资本， 全国儿童医院（NCH）和俄亥俄州州立大学（OSU），以及共同领导人布罗克博士， McAllearney和Lin各自领导了专业和多学科团队，具有广泛的影响力， 多个健康领域。MC将与ASPIRES研究者合作，以促进儿科人群1） 开发和测试新的和可扩展的干预措施和研究产生的资源， 呼吁利益攸关方; 2）迅速和广泛传播新的有效做法; 3）持续 改善在现实世界环境中提供的自杀预防干预措施; 4）跨学科团队 科学，以促进新的和收敛的解决方案，以解决棘手的自杀预防挑战;和5）培训 来自不同背景的学生，研究员，早期职业生涯和高级研究人员，以增加 多样性的研究人员进行尖端的转化自杀预防研究。我们的MC提供 方法论的锚连接所有ASPIRES项目，我们的跨学科团队与实质性的 NCH和OSU的专业知识、资源和基础设施将确保所有ASPIRES项目 以科学的严谨性进行并广泛传播。与零自杀研究所（Zero Suicide Institute）合作 和俄勒冈州立大学CCTS试点项目计划扩大了外展，参与和传播。方法学 我们的MC的技术进步为克服面临的挑战提供了创新方法 降低青少年自杀率的行为干预。协同研究设计要素 ASPIRES项目为研究自杀的实施和有效性方面提供了独特的机会 在初级、专科和急症护理中采取预防干预措施。总的来说，这些发展支持 对ASPIRES干预措施进行创新和严格的评估，并为进一步设计提供基础 并完善必要的实施战略，以在未来的研究中扩大这些干预措施。