Transcriptional Control of High-thermogenic Adipocyte Development
高产热脂肪细胞发育的转录控制
基本信息
- 批准号:10435752
- 负责人:
- 金额:$ 36.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-20 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AblationAdipocytesAdipose tissueAdultAmino AcidsAreaBiogenesisBiologicalBiological AssayBiologyBrown FatCell Differentiation processCell ProliferationCellsDevelopmentDiphtheria ToxinDiseaseEnergy MetabolismExhibitsFamilyFatty AcidsFoundationsFutile CyclingGenesGlucoseHealthHeterogeneityHomeostasisHumanImmune responseInsulin ResistanceKnowledgeLinkLipidsLipolysisMaintenanceMediatingMetabolicMetabolic DiseasesMetabolismMitochondriaModelingMusObesityOxidative PhosphorylationPathway interactionsPhysiologicalPhysiologyPlayPopulationRegulationResearchResearch SubjectsRodentRoleSmall Nuclear RNASolidTestingThermogenesisTissuesTranscription Factor AP-1Transcriptional RegulationVascularizationadipocyte differentiationbaseblood glucose regulationcardiometabolismdiet-induced obesityestrogen-related receptorglucose metabolismimprovedinsightlipid biosynthesismembermouse modelnovelobesity treatmentprecursor cellresponsestem cellstherapeutic developmenttherapeutic targettranscription factoruncoupling protein 1
项目摘要
Brown adipose tissue is composed of heterogenous adipocyte populations evidenced by the coexistence
of low-thermogenic adipocytes (mitochondria content low and uncoupling protein 1 (UCP1) low) and high-
thermogenic adipocytes within the tissue, a fundamental feature of adipocyte heterogeneity and plasticity.
However, the mechanisms underlying adipocyte heterogeneity and its significance in metabolic physiology and
disease remain poorly defined. In our preliminary study, we discovered a population of JunB-enriched
adipocytes (JunB+ adipocytes) within the brown fat depot that exhibits lower thermogenic capacity and less
lipid droplets compared to high-thermogenic adipocytes. The abundance of JunB+ adipocytes is increased
during obesity. Through snRNA-seq and functional assays, we observed that inactivation of JunB in adipocytes
increased the fraction of adipocytes exhibiting high mitochondrial content and thermogenic capacity.
Importantly, JunB ablation in UCP1+ adipocytes resulted in enhanced basal and cold-induced energy
expenditure and protected mice against diet-induced obesity. Based upon these novel findings, we
hypothesize that JunB serves a critical role in governing adipocyte heterogeneity and systemic energy
and glucose homeostasis. We will elucidate the mechanisms by which JunB suppresses high-thermogenic
cell differentiation and explore the regulation of JunB+ adipocyte development by examining the identity, origin,
and fate of this distinct subpopulation. We will also use Diphtheria toxin gene A chain (DTA)-
mediated approach to ablate JunB+ adipocytes within adipose tissue to determine the physiological role of this
subpopulation in regulating energy and glucose metabolism. Characterization of JunB in regulating adipocyte
heterogeneity and plasticity will provide novel knowledge to the biology of brown adipocyte and a solid
foundation to aid in the development of therapeutic interventions for obesity and its associated disorders.
棕色脂肪组织是由异质脂肪细胞群组成的,它们的共存证明了这一点
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Meilian Liu其他文献
Meilian Liu的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Meilian Liu', 18)}}的其他基金
Transcriptional Control of High-thermogenic Adipocyte Development
高产热脂肪细胞发育的转录控制
- 批准号:
10612098 - 财政年份:2022
- 资助金额:
$ 36.98万 - 项目类别:
The Role of Adiponectin in Regulating Group 2 Innate Lymphoid Cells and Browning in Fat
脂联素在调节 2 组先天淋巴细胞和脂肪褐变中的作用
- 批准号:
9379783 - 财政年份:2017
- 资助金额:
$ 36.98万 - 项目类别:
The Role of Adiponectin in Regulating Group 2 Innate Lymphoid Cells and Browning in Fat
脂联素在调节 2 组先天淋巴细胞和脂肪褐变中的作用
- 批准号:
10165701 - 财政年份:2017
- 资助金额:
$ 36.98万 - 项目类别:
The Role of Adiponectin in Regulating Group 2 Innate Lymphoid Cells and Browning in Fat
脂联素在调节 2 组先天淋巴细胞和脂肪褐变中的作用
- 批准号:
10091038 - 财政年份:2017
- 资助金额:
$ 36.98万 - 项目类别:
Regulation of Beige Fat Development by mTORC1 and Autophagy
mTORC1 和自噬对米色脂肪发育的调节
- 批准号:
9207190 - 财政年份:
- 资助金额:
$ 36.98万 - 项目类别:
相似国自然基金
支链氨基酸代谢紊乱调控“Adipocytes - Macrophages Crosstalk”诱发2型糖尿病脂肪组织功能和结构障碍的作用及机制
- 批准号:81970721
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
相似海外基金
Recruitment of brown adipocytes in visceral white adipose tissue by fibroblast growth factor 8b
成纤维细胞生长因子 8b 将棕色脂肪细胞募集到内脏白色脂肪组织中
- 批准号:
321208980 - 财政年份:2016
- 资助金额:
$ 36.98万 - 项目类别:
Research Grants
Enhancing Energy Expending Adipocytes in White Adipose Tissue
增强白色脂肪组织中的能量消耗脂肪细胞
- 批准号:
8827438 - 财政年份:2014
- 资助金额:
$ 36.98万 - 项目类别:
Induction of brown-like adipocytes in white adipose tissue by food-derived factors
食物源性因子在白色脂肪组织中诱导棕色样脂肪细胞
- 批准号:
26450168 - 财政年份:2014
- 资助金额:
$ 36.98万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
WAT-on-a-chip - Development of a micofluidic, microphysiologic in vitro adipose tissue model for high-throughput drug screening based on hiPSC-derived adipocytes.
WAT-on-a-chip - 开发微流体、微生理体外脂肪组织模型,用于基于 hiPSC 衍生脂肪细胞的高通量药物筛选。
- 批准号:
257256526 - 财政年份:2014
- 资助金额:
$ 36.98万 - 项目类别:
Research Fellowships
Enhancing Energy Expending Adipocytes in White Adipose Tissue
增强白色脂肪组织中的能量消耗脂肪细胞
- 批准号:
8828181 - 财政年份:2013
- 资助金额:
$ 36.98万 - 项目类别:
Enhancing Energy Expending Adipocytes in White Adipose Tissue
增强白色脂肪组织中的能量消耗脂肪细胞
- 批准号:
8520690 - 财政年份:2013
- 资助金额:
$ 36.98万 - 项目类别:
Enhancing Energy Expending Adipocytes in White Adipose Tissue
增强白色脂肪组织中的能量消耗脂肪细胞
- 批准号:
8629741 - 财政年份:2013
- 资助金额:
$ 36.98万 - 项目类别:
Effect of exercise training on formation of brite adipocytes within white adipose tissue
运动训练对白色脂肪组织内脂肪细胞形成的影响
- 批准号:
23700778 - 财政年份:2011
- 资助金额:
$ 36.98万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Investigation for the mechanisms of the emergence of brown adipocytes in white adipose tissue
白色脂肪组织中棕色脂肪细胞出现机制的研究
- 批准号:
21780261 - 财政年份:2009
- 资助金额:
$ 36.98万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
LOUISIANA COBRE: P1: INDUCE THERMOGENIC BROWN ADIPOCYTES IN WHITE ADIPOSE TISSUE
路易斯安那 COBRE:P1:在白色脂肪组织中诱导产热棕色脂肪细胞
- 批准号:
7610781 - 财政年份:2007
- 资助金额:
$ 36.98万 - 项目类别: