Investigation for the mechanisms of the emergence of brown adipocytes in white adipose tissue

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Brown adipose tissue (BAT) is a tissue specified for metabolic heat production and expected to be a target for the treatment of obesity. To maximize the anti-obesity effect of BAT thermogenesis, activation of the thermogenic function or induction of tissue hyperplasia would be effective. Generally, the number of adipocyte is controlled by the proliferation of pre-adipocytes and their differentiation. In this study, we revealed that brown adipocytes proliferate not only before, but also after their differentiation.