Investigation for the mechanisms of the emergence of brown adipocytes in white adipose tissue

白色脂肪组织中棕色脂肪细胞出现机制的研究

• 批准号: 21780261
• 负责人: OKAMATSU Yuko
• 金额: $ 2.83万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21780261/
• 关键词: 脂肪細胞; 褐色脂肪; 肥満; 脱共役蛋白質; 脱共役タンパク質

Brown adipose tissue (BAT) is a tissue specified for metabolic heat production and expected to be a target for the treatment of obesity. To maximize the anti-obesity effect of BAT thermogenesis, activation of the thermogenic function or induction of tissue hyperplasia would be effective. Generally, the number of adipocyte is controlled by the proliferation of pre-adipocytes and their differentiation. In this study, we revealed that brown adipocytes proliferate not only before, but also after their differentiation.

棕色脂肪组织（BAT）是一种专门用于代谢产热的组织，预计将成为治疗肥胖症的靶点。为了使BAT产热的抗肥胖效果最大化，激活产热功能或诱导组织增生将是有效的。一般来说，脂肪细胞的数量是由前脂肪细胞的增殖和分化控制的。在这项研究中，我们发现，棕色脂肪细胞增殖不仅之前，而且在分化后。

项目成果

High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity.

• DOI: 10.2337/db09-0530
• 发表时间: 2009-07
• 期刊: Diabetes
• 影响因子: 7.7
• 作者: Saito M;Okamatsu-Ogura Y;Matsushita M;Watanabe K;Yoneshiro T;Nio-Kobayashi J;Iwanaga T;Miyagawa M;Kameya T;Nakada K;Kawai Y;Tsujisaki M
• 通讯作者: Tsujisaki M

Thermogenic UCP1 enhances anorexigenic effect of leptin in mice

产热 UCP1 增强小鼠瘦素的厌食作用

• 发表时间: 2009
• 作者: Yuko Okamatsu-Ogura;Akira Terao;Kazuhiro Kimura;Masayuki Saito
• 通讯作者: Masayuki Saito

Thermogenic UCP1 controls appetite through modulation of leptin sensitivity

产热 UCP1 通过调节瘦素敏感性来控制食欲

• 发表时间: 2009
• 作者: Yuko Okamatsu-Ogura;Akira Terao;Kazuhiro Kimura;Masayuki Saito
• 通讯作者: Masayuki Saito

褐色脂肪細胞によるエネルギー代謝制御におけるPGC-1の役割

PGC-1在调节棕色脂肪细胞能量代谢中的作用

• 发表时间: 2009
• 期刊: 内分泌・糖尿病科
• 作者: 岡松優子;木村和弘
• 通讯作者: 木村和弘