Super-Resolution Imaging of Higher-Order Heterochromatin Structure for Early Detection of Lung Carcinogenesis

高阶异染色质结构的超分辨率成像用于早期检测肺癌

基本信息

  • 批准号:
    10435645
  • 负责人:
  • 金额:
    $ 22.21万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-03-15 至 2024-02-29
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT Lung cancer is the leading cause of cancer-related death in the United States. Overall, patients diagnosed with early-stage lung cancer have a much better prognosis. Cigarette smoking is the major cause of lung cancer and screening for lung cancer is currently recommended for high-risk current and former smokers. Compared with nonsmokers, smokers have an almost 30-fold increased risk of developing lung cancer. Unfortunately, despite significant efforts, early detection of lung cancer remains sub-optimal with conventional approaches suffering from high false-positive rates or limited sensitivity. Improved understanding of the early events underlying smoking-related lung cancer development is crucial to the identification of new biomarkers and targets for early detection and prevention. Further, new methods that detect those early events in lung cancer development in a non-invasive and cost-effective manner with high sensitivity and specificity are urgently needed. Recent advances in super-resolution microscopy revolutionize the field of optical microscopy and offer a new ability to visualize molecular structure at nanometer resolution that is invisible under a conventional light microscope. We propose an innovative approach to adapt super-resolution microscopy to improve the early detection of lung cancer. Our approach is built upon our recent discovery that chromatin folding becomes gradually fragmented in early lung carcinogenesis, even when cells still appear normal under conventional light microscope. Our ultimate goal is to detect such nanoscale chromatin “misfolding” in bronchial cells present in sputum to improve early detection of lung cancer. In this project, we will first establish disrupted nanoscale chromatin folding as an early event in lung carcinogenesis utilizing a mouse model of carcinogen-induced lung adenocarcinoma as well as existing well-annotated human lung tissue specimens (Aim 1). In addition, we will evaluate the feasibility of super-resolution imaging of nanoscale chromatin “misfolding” for early detection of lung cancer using existing sputum samples and data from the Pittsburgh Lung Screening Study, a community- based research cohort of current and ex-smokers, screened with low-dose computed tomography and followed for lung cancer (Aim 2).
项目总结/文摘

项目成果

期刊论文数量(0)
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会议论文数量(0)
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Yang Liu其他文献

Formal Verification of Process Layer with Petri nets and Z
使用 Petri 网和 Z 对过程层进行形式化验证
An efficient p-ECR move based on maximum likelihood by neighbor joining
基于邻居加入最大似然的高效 p-ECR 移动
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    3
  • 作者:
    Yang Liu;Jian-Fu Li;Mao-Zu Guo,
  • 通讯作者:
    Mao-Zu Guo,
Secure multi-label data classification in cloud by additionally homomorphic encryption
通过额外的同态加密在云中保护多标签数据分类
  • DOI:
  • 发表时间:
    2018
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Yi Liu Yu Luo;Youwen Zhu;Yang Liu;Xingxin Li
  • 通讯作者:
    Xingxin Li
Requirement Verification of Networked Software Goals with Multi-valued Logic
具有多值逻辑的网络化软件目标的需求验证

Yang Liu的其他文献

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{{ truncateString('Yang Liu', 18)}}的其他基金

Spatially resolved multiomics profiling of microbes and their host tissue
微生物及其宿主组织的空间分辨多组学分析
  • 批准号:
    10713736
  • 财政年份:
    2023
  • 资助金额:
    $ 22.21万
  • 项目类别:
Mapping the Cellular Responses to DNA Double-Strand Breaks Using On-Demand CRISPR technologies and High-resolution Fluorescence Microscopy
使用按需 CRISPR 技术和高分辨率荧光显微镜绘制细胞对 DNA 双链断裂的反应
  • 批准号:
    10715720
  • 财政年份:
    2023
  • 资助金额:
    $ 22.21万
  • 项目类别:
Climate & Health Actionable Research and Translation Center
气候
  • 批准号:
    10835460
  • 财政年份:
    2023
  • 资助金额:
    $ 22.21万
  • 项目类别:
Climate & Health Actionable Research and Translation Center
气候
  • 批准号:
    10835461
  • 财政年份:
    2023
  • 资助金额:
    $ 22.21万
  • 项目类别:
Imaging nanoscale chromatin folding in early carcinogenesis
早期致癌过程中纳米级染色质折叠的成像
  • 批准号:
    10398183
  • 财政年份:
    2020
  • 资助金额:
    $ 22.21万
  • 项目类别:
Imaging nanoscale chromatin folding in early carcinogenesis
早期致癌过程中纳米级染色质折叠的成像
  • 批准号:
    10605199
  • 财政年份:
    2020
  • 资助金额:
    $ 22.21万
  • 项目类别:
Imaging nanoscale chromatin folding in early carcinogenesis
早期致癌过程中纳米级染色质折叠的成像
  • 批准号:
    10223251
  • 财政年份:
    2020
  • 资助金额:
    $ 22.21万
  • 项目类别:
Three dimensional nanoscale nuclear architecture mapping based taxonomy of precursor lesions for predicting colorectal cancer risk
基于三维纳米级核结构映射的前体病变分类法用于预测结直肠癌风险
  • 批准号:
    9756510
  • 财政年份:
    2019
  • 资助金额:
    $ 22.21万
  • 项目类别:
Three dimensional nanoscale nuclear architecture mapping based taxonomy of precursor lesions for predicting colorectal cancer risk
基于三维纳米级核结构映射的前体病变分类法用于预测结直肠癌风险
  • 批准号:
    10590702
  • 财政年份:
    2019
  • 资助金额:
    $ 22.21万
  • 项目类别:
Three dimensional nanoscale nuclear architecture mapping based taxonomy of precursor lesions for predicting colorectal cancer risk
基于三维纳米级核结构映射的前体病变分类法用于预测结直肠癌风险
  • 批准号:
    10373010
  • 财政年份:
    2019
  • 资助金额:
    $ 22.21万
  • 项目类别:

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吸烟者和电子烟使用者急性电子烟暴露的 MRI 和生物标志物
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