Primary cilia loss and cell cycle re-entry in Chlamydia-infected cells

衣原体感染细胞中的初级纤毛丢失和细胞周期重新进入

基本信息

  • 批准号:
    10436218
  • 负责人:
  • 金额:
    $ 55.17万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-07-17 至 2025-06-30
  • 项目状态:
    未结题

项目摘要

Project Summary/Abstract More than 1.7 million cases of Chlamydia trachomatis infections are reported to the CDC each year, making it the most commonly reported infectious disease in the country. C. trachomatis causes an intracellular infection, and we have discovered that this bacterium causes two effects on an infected host cell that have not been previously described: 1) loss of the primary cilium, which is a solitary surface projection on most differentiated cells in the body; 2) re-entry of a quiescent host cell into the cell cycle. These novel host-pathogen interactions may have been missed because the conventional Chlamydia cell culture infection model uses cycling cells that lack primary cilia. In Aim 1, we will determine if Chlamydia infection causes loss of the primary cilium by inducing cilia disassembly through the AurA regulatory pathway of the host cell. In Aim 2, we will investigate how Chlamydia causes cell cycle re-entry and will determine if the infection involves and dysregulates known cellular regulators of cell cycle re-entry and progression. In Aim 3, we will study if and how Chlamydia-induced primary cilia loss and cell cycle re-entry promote the chlamydial infection. We will also investigate if these two host-pathogen interaction are functionally linked or independent from each other. Successful completion of these studies will define two novel host-pathogen interactions: no microbe is known to cause primary cilia loss, and only viruses, but not bacteria, have been shown to cause quiescent host cells to re-enter the cell cycle. Interventions to prevent Chlamydia-induced primary cilia loss and cell cycle re-entry may lead to a novel therapeutic strategy against Chlamydia infections.
项目总结/文摘

项目成果

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专利数量(0)

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CHRISTINE SUETTERLIN其他文献

CHRISTINE SUETTERLIN的其他文献

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{{ truncateString('CHRISTINE SUETTERLIN', 18)}}的其他基金

Development of a novel protein depletion method in Chlamydia
开发衣原体中新型蛋白质消耗方法
  • 批准号:
    10672121
  • 财政年份:
    2023
  • 资助金额:
    $ 55.17万
  • 项目类别:
Primary cilia loss and cell cycle re-entry in Chlamydia-infected cells
衣原体感染细胞中的初级纤毛丢失和细胞周期重新进入
  • 批准号:
    10219072
  • 财政年份:
    2020
  • 资助金额:
    $ 55.17万
  • 项目类别:
Primary cilia loss and cell cycle re-entry in Chlamydia-infected cells
衣原体感染细胞中的初级纤毛丢失和细胞周期重新进入
  • 批准号:
    10542655
  • 财政年份:
    2020
  • 资助金额:
    $ 55.17万
  • 项目类别:
Primary cilia loss and cell cycle re-entry in Chlamydia-infected cells
衣原体感染细胞中的初级纤毛丢失和细胞周期重新进入
  • 批准号:
    10721398
  • 财政年份:
    2020
  • 资助金额:
    $ 55.17万
  • 项目类别:
Primary cilia loss and cell cycle re-entry in Chlamydia-infected cells
衣原体感染细胞中的初级纤毛丢失和细胞周期重新进入
  • 批准号:
    10470411
  • 财政年份:
    2020
  • 资助金额:
    $ 55.17万
  • 项目类别:
Primary cilia loss and cell cycle re-entry in Chlamydia-infected cells
衣原体感染细胞中的初级纤毛丢失和细胞周期重新进入
  • 批准号:
    10656471
  • 财政年份:
    2020
  • 资助金额:
    $ 55.17万
  • 项目类别:
Primary cilia loss and cell cycle re-entry in Chlamydia-infected cells
衣原体感染细胞中的初级纤毛丢失和细胞周期重新进入
  • 批准号:
    10033880
  • 财政年份:
    2020
  • 资助金额:
    $ 55.17万
  • 项目类别:
MECHANISM OF CHLAMYDIA-INDUCED CENTROSOME AMPLIFICATION
衣原体诱导中心体扩增的机制
  • 批准号:
    8361944
  • 财政年份:
    2011
  • 资助金额:
    $ 55.17万
  • 项目类别:
Mechanism of centrosome regulation from the Golgi
高尔基体调节中心体的机制
  • 批准号:
    8462130
  • 财政年份:
    2010
  • 资助金额:
    $ 55.17万
  • 项目类别:
Mechanism of centrosome regulation from the Golgi
高尔基体调节中心体的机制
  • 批准号:
    8066977
  • 财政年份:
    2010
  • 资助金额:
    $ 55.17万
  • 项目类别:

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