CENTER FOR RESEARCH ON STRUCTURAL BIOLOGY OF INFECTIOUS DISEASES: RESEARCH ON RESISTANT BACTERIA

传染病结构生物学研究中心：耐药细菌研究

• 批准号: 10788164
• 负责人: PETER MYLER
• 金额: $ 145.5万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10788164
• 关键词: 3-Dimensional; Advanced Development; Bacterial Drug Resistance; Basic Science; Biological; Biomedical Research; Communicable Diseases; Gram-Negative Bacteria; Gram-Positive Bacteria; Molecular; Proteins; Research; Research Project Grants; Research Support; Role; Structure; Technology; bacterial resistance; pathogen; programs; structural biology; three dimensional structure; universal influenza vaccine

To apply state-of-the-art, high-throughput structural biology technologies to experimentally characterize the three-dimensional atomic structure of targeted proteins to advance the development of a universal influenza vaccine. This program also supports research projects that utilize the 3D structure information and experimental approaches to better characterize the molecular functional role of protein targets. The primary focus of the Center is pathogen proteins that are expected to have an important biological role and a potential impact on biomedical research.

应用最先进的高通量结构生物学技术来通过实验表征目标蛋白质的三维原子结构，以推进通用流感疫苗的开发。该计划还支持利用 3D 结构信息和实验方法更好地表征蛋白质靶标的分子功能作用的研究项目。该中心的主要关注点是病原体蛋白，这些蛋白有望发挥重要的生物学作用并对生物医学研究产生潜在影响。