TR&D2: Nanoimmunomaterials for Immune Engineering

DR&D2摘要/叙述-用于免疫工程的纳米免疫材料 TR&D2通过设计和合成新的生物材料和 为免疫调节而制造的纳米材料。构建了聚合物和聚合物颗粒体系 可独立控制颗粒芯的物理性质和化学表面，以实现所需 仿生生物学特性。NIMS是为细胞内、细胞外的核酸输送而构建的 生物分子从表面的呈现，以及两种机制的结合。这些NIM 用于免疫刺激和免疫抑制应用。此外，还将共享NIM 通过CP和SP项目、其他研发，并供不同的研究人员协作和使用。NIMS将是 评估以提高采用细胞移植(ACT)和基于颗粒的技术的有效性 脱细胞免疫疗法在人类健康的广泛领域和应用。Tr&d2支持和 在使用工程原理(化学工程、材料科学和 工程和生物医学工程)来设计使能免疫工程技术和高级 免疫疗法。

TR&D2 Abstract / Narrative - Nanoimmunomaterials for Immune Engineering TR&D2 advances nanoimmunomaterials (NIMs) through the design and synthesis of new biomaterials and nanomaterials created for immunomodulation. Polymers and polymeric particle-based systems are constructed with independent control of the particle core physical properties and the chemical surface to enable desired biomimetic biological properties. NIMs are constructed for intracellular delivery of nucleic acids, extracellular presentation of biological molecules from surfaces, and for the combination of both mechanisms. These NIMs are utilized for both immunostimulatory and immunosuppressive applications. Additionally, NIMs will be shared with CP and SP projects, other TR&Ds, and for collaboration and use by varied researchers. NIMs will be evaluated to improve the efficacy of techniques for both Adoptive Cell Transfer (ACT) and particle-based acellular immunotherapeutics for wide ranging fields and applications to human health. TR&D2 supports and aligns with the JH-TIE vision in its use of engineering principles (Chemical Engineering, Materials Science & Engineering, and Biomedical Engineering) to design enabling immunoengineering technology and advanced immunotherapy.