TR&D2: Nanoimmunomaterials for Immune Engineering

基本信息

批准号：
10436871
负责人：
Jordan Green
金额：
$ 31.52万
依托单位：
JOHNS HOPKINS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-15 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10436871
关键词：
Adoptive Cell Transfers Amines Antigens Biocompatible Materials Biodistribution Biological Biological Assay Biomedical Engineering Biomimetics Biophysics Biotechnology CD8-Positive T-Lymphocytes Cells Cellular immunotherapy Chemical Engineering Chemicals Collaborations Cytotoxic T-Lymphocytes Dendritic Cells Drug Kinetics Engineering Esters Formulation Gene Delivery Gene-Modified Goals Health Human Immune Immune system Immunization Immunosuppression Immunotherapeutic agent Immunotherapy In Situ In Vitro Libraries Mediating Membrane Fluidity Membrane Proteins Modification Nucleic Acids Nucleosome Core Particle Polymers Property Proteins Regulatory T-Lymphocyte Reporter Reporter Genes Reporting Research Personnel Safety Shapes Signal Transduction Signaling Molecule Specificity Surface Surface Properties System T-Cell Receptor T-Lymphocyte Techniques Technology Time Toxic effect Transfection Vision base biodegradable polymer biomaterial compatibility cell type cellular engineering comparative design engineered T cells extracellular flexibility fluidity genetic vaccine immunoengineering immunoregulation improved in vivo materials science melanoma mouse model nano nanoformulation nanomaterials nanoparticle next generation novel nucleic acid delivery particle physical property systemic toxicity tool tumor

项目摘要

TR&D2 Abstract / Narrative - Nanoimmunomaterials for Immune Engineering TR&D2 advances nanoimmunomaterials (NIMs) through the design and synthesis of new biomaterials and nanomaterials created for immunomodulation. Polymers and polymeric particle-based systems are constructed with independent control of the particle core physical properties and the chemical surface to enable desired biomimetic biological properties. NIMs are constructed for intracellular delivery of nucleic acids, extracellular presentation of biological molecules from surfaces, and for the combination of both mechanisms. These NIMs are utilized for both immunostimulatory and immunosuppressive applications. Additionally, NIMs will be shared with CP and SP projects, other TR&Ds, and for collaboration and use by varied researchers. NIMs will be evaluated to improve the efficacy of techniques for both Adoptive Cell Transfer (ACT) and particle-based acellular immunotherapeutics for wide ranging fields and applications to human health. TR&D2 supports and aligns with the JH-TIE vision in its use of engineering principles (Chemical Engineering, Materials Science & Engineering, and Biomedical Engineering) to design enabling immunoengineering technology and advanced immunotherapy.

TR＆D2摘要 /叙述 - 免疫工程的纳米免疫材料 TR＆D2通过新生物材料的设计和合成纳米免疫材料（NIMS）为免疫调节而创建的纳米材料。聚合物和聚合物粒子基系统构建独立控制粒子核心物理特性和化学表面以实现所需的仿生生物学特性。 NIM是用于细胞内核酸，细胞外的从表面表现出生物分子，以及两种机制的组合。这些nims 用于免疫刺激和免疫抑制应用。此外，NIMS将共享通过CP和SP项目，其他TR＆D，以及各种研究人员的协作和使用。尼姆会评估以提高收养细胞转移（ACT）和基于粒子的技术的疗效细胞免疫治疗药，用于广泛的领域和对人类健康的应用。 TR＆D2支持和与JH-TIE愿景相吻合，在使用工程原理（化学工程，材料科学和工程和生物医学工程）设计实现免疫工程技术和高级免疫疗法。