TR&D2: Nanoimmunomaterials for Immune Engineering

TR&D2摘要/叙述-用于免疫工程的纳米免疫材料 TR&D2通过设计和合成新的生物材料来推进纳米免疫材料（NIMs）， 用于免疫调节的纳米材料。聚合物和聚合物颗粒为基础的系统， 通过独立控制颗粒核的物理性质和化学表面， 仿生生物学特性。NIM被构建用于核酸的细胞内递送、细胞外递送和细胞外递送。 从表面呈现生物分子，以及两种机制的组合。这些NIM 用于免疫刺激和免疫抑制应用。此外，NIM将被共享 与CP和SP项目，其他TR& D合作，并供不同研究人员使用。NIM将是 评估以提高连续性细胞转移（ACT）和基于颗粒的 脱细胞免疫治疗剂，用于广泛的领域和人类健康的应用。TR&D2支持和 与JH-TIE的愿景保持一致，采用工程原理（化学工程、材料科学和 工程和生物医学工程），以设计使免疫工程技术和先进的 免疫疗法

TR&D2 Abstract / Narrative - Nanoimmunomaterials for Immune Engineering TR&D2 advances nanoimmunomaterials (NIMs) through the design and synthesis of new biomaterials and nanomaterials created for immunomodulation. Polymers and polymeric particle-based systems are constructed with independent control of the particle core physical properties and the chemical surface to enable desired biomimetic biological properties. NIMs are constructed for intracellular delivery of nucleic acids, extracellular presentation of biological molecules from surfaces, and for the combination of both mechanisms. These NIMs are utilized for both immunostimulatory and immunosuppressive applications. Additionally, NIMs will be shared with CP and SP projects, other TR&Ds, and for collaboration and use by varied researchers. NIMs will be evaluated to improve the efficacy of techniques for both Adoptive Cell Transfer (ACT) and particle-based acellular immunotherapeutics for wide ranging fields and applications to human health. TR&D2 supports and aligns with the JH-TIE vision in its use of engineering principles (Chemical Engineering, Materials Science & Engineering, and Biomedical Engineering) to design enabling immunoengineering technology and advanced immunotherapy.