权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Behavioral and Neural Correlates of Social Function in Alcohol Use Disorders

酒精使用障碍中社会功能的行为和神经相关性

基本信息

批准号：
10436819
负责人：
ANDREW S KAYSER
金额：
$ 45.6万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-15 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10436819
关键词：
Alcoholics Anonymous Alcoholism Anterior Behavior Behavioral Behavioral Mechanisms Biological Assay Biological Markers Brain Brain region Characteristics Clinical Treatment Cognitive Competence Complication Computer Models Conflict (Psychology)DSM-V Data Deception Development Diagnostic Economics Foundations Functional Magnetic Resonance Imaging Goals Human Impairment Incentives Individual Insula of Reil Interpersonal Relations Link Measures Modeling Nature Nurses Occupations Patients Perception Questionnaires Recording of previous events Resources Rewards Schizotypal Personality Disorder Social Behavior Social Environment Social Functioning Social Perception Substance Use Disorder Therapeutic Translating Variant Ventral Striatum Work addiction affective neuroscience alcohol use disorder base cognitive neuroscience diagnostic criteria experimental study neural circuit neural correlate neuroeconomics neuroimaging neuromechanism psychologic relating to nervous system research clinical testing social social cognition social deficits social influence social neuroscience theories trait

项目摘要

Project Summary Despite the widespread nature of social deficits in patients with alcohol use disorders (AUDs) and the foundational importance of adequate social function for therapies (which often directly depend upon group and other interpersonal interactions), the behavioral and neural basis of social impairments in AUDs remains understudied. A significant challenge for understanding such impairments is to link high-level theories of social behavior and cognition with the computations performed by brain circuits. Specifically, how does the brain translate social perception into social valuation, and how does such valuation influence social actions? We propose to leverage recent developments in economic theory and cognitive neuroscience to bridge this divide using a computational, model-based approach. In this proposal, we hypothesize that social impairments in subjects with alcohol use disorders are manifest in the perception of potential social partners and the value consequently assigned to them, impacting the actions that result. By evaluating well-established economic games, we will quantify how subjects with AUDs divide rewards between themselves and anonymous partners in different social contexts. We will manipulate both incentives related to how subjects divide monetary resources between themselves and various social partners, as well as the characteristics of the partners themselves by employing validated quantitative measures of social perception. To unravel the neural mechanisms supporting the above choices, we will use functional MRI to assess brain regions whose activity we hypothesize will vary parametrically with monetary decisions. We thus seek to broaden our understanding of the computations and circuits underlying social behavior. Moreover, we believe that a model-based understanding of these behaviors and neural circuits may someday guide more robust and quantitative assessments of social function in patients with alcohol use disorders, with possible implications for both clinical evaluation and treatment.

项目总结