Proof of concept study of a highly novel food fortification to boost exercise performance in younger and older adults

一种高度新颖的食品强化剂的概念验证研究，可提高年轻人和老年人的运动表现

• 批准号: 10073883
• 金额: $ 54.14万
• 依托单位: MITOCHONDRIAL SUBSTRATE INVENTION LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10073883
• 关键词: Proof; concept; study; highly; novel

A vital function of every cell in our bodies is the process of metabolism. For our cells and bodies to function, they need access to an energy carrying molecule called adenosine triphosphate (ATP). Sadly as we age our body's ability to produce sufficient ATP declines and our physical and mental wellbeing declines in parallel. One way to offset this decline is to develop effective food supplements that maintain cell metabolism (i.e. our cells' access to energy).We are developing a food supplement called Mitocholine(tm), the supplement includes three natural compounds that, when taken orally, become available to the cells to keep them energised and functional.Mitocholine(tm) has the potential to help the cells in our brain function more effectively. The Mitocholine team is currently testing this supplement in older people to see if it helps improve how their brain works and reduce the memory loss issues. This study is not yet complete, but early results show a potential positive benefit to brain health in the elderly.Mitocholine now has the potential to develop a variant of Mitocholine(tm) that is suitable to put in foods as a supplement to support the cells in our muscles and support improved ability to exercise and boost physical energy levels. This concept is important because Western diets are known to be low in key components in the Mitocholine(tm) supplement. This insufficiency is particularly challenging for pregnant women. Mitocholine(tm) has the potential to address this deficiency in our diets while also supporting physical and mental wellbeing.The aim of the proposed project is to understand if a Mitocholine(tm) containing food additive, by providing additional fuel to our muscle cells, will enhance aerobic fitness and exercise performance. This proposed research will investigate how effectively young and older adults can exercise after taking Mitocholine(tm) food additive compared to a placebo. Mitocholine will work closely with expert sports scientists at the University of Exeter to test volunteers' capacity to perform different types of exercise after taking the food supplement.If Mitocholine is able to demonstrate that the supplement works, it will be able to secure commercial sales of the supplement to specialist food producers globally.

我们体内每个细胞的重要功能是新陈代谢过程。为了让我们的细胞和身体发挥功能，它们需要获取一种称为三磷酸腺苷 (ATP) 的能量携带分子。遗憾的是，随着年龄的增长，我们的身体产生足够 ATP 的能力会下降，我们的身心健康也会随之下降。抵消这种下降的方法之一是开发有效的食品补充剂，维持细胞新陈代谢（即我们的细胞获取能量）。我们正在开发一种名为 Mitocholine(tm) 的食品补充剂，该补充剂包含三种天然化合物，口服时，细胞可以利用这些化合物来保持细胞活力和功能。Mitocholine(tm) 有潜力帮助我们大脑中的细胞更有效地发挥作用。线粒体胆碱团队目前正在老年人中测试这种补充剂，看看它是否有助于改善他们的大脑工作方式并减少记忆丧失问题。这项研究尚未完成，但早期结果显示对老年人的大脑健康具有潜在的积极益处。 线粒体胆碱现在有可能开发出一种线粒体胆碱 (tm) 变体，适合将其作为补充剂添加到食物中，以支持我们肌肉中的细胞，并支持提高运动能力和提高身体能量水平。这个概念很重要，因为众所周知，西方饮食中线粒体胆碱(tm) 补充剂的关键成分含量较低。这种不足对于孕妇来说尤其具有挑战性。线粒体胆碱 (tm) 有潜力解决我们饮食中的这一缺陷，同时也支持身心健康。拟议项目的目的是了解含有食品添加剂的线粒体胆碱 (tm) 是否可以通过为我们的肌肉细胞提供额外的燃料来增强有氧健身和运动表现。这项拟议的研究将调查与安慰剂相比，年轻人和老年人在服用 Mitocholine(tm) 食品添加剂后锻炼的效果如何。 Mitocholine 将与埃克塞特大学的专家运动科学家密切合作，测试志愿者在服用食品补充剂后进行不同类型运动的能力。如果 Mitocholine 能够证明该补充剂有效，它将能够确保该补充剂向全球专业食品生产商进行商业销售。