Network on Biomarker Collection and Measurement in Population Studies of Aging: 2022-2027

这次更新的目标是保持和进一步发展跨学科的科学家网络 致力于改善对晚年健康结果的生物风险的测量， 有代表性的人口样本。生物风险由基因组和生理状态的指标定义 增加疾病、残疾、身体或认知功能丧失或死亡的可能性。的 该网络将继续侧重于评估、验证和协调研究中的生物风险测量 扩大可用于人口的老年科学措施; 在分析模型中纳入健康的复杂层面的方法。目前这个项目 将在建立初步跨学科研究网络（由NIA资助）的广泛进展的基础上 从2009年到2015年）和该网络的先前迭代（2016 - 2021）。过去5年来， 统一信息和统一数据是该网络的一个主要产品。网络传播 采集方法、测定方法、质量控制方法、协调方法、基本 关于样品收集和制备以及分析方法等相关主题的培训。网络推广 有效的跨学科和国际研究的协会的社会，生物，经济， 心理因素和导致健康结果的生物学途径在老年人中普遍存在， 社区和国家人口调查。 除了维持上一个供资期间所作的统一和培训努力外， 该网络将在2022 - 2027年期间重点开展至少4项新活动。更加重视的领域 包括：1）协调生命中健康和衰老的分子（如表观遗传和RNA）生物标志物 课程，2）探索新兴的老年科学生物标志物，用于大型代表性研究的潜在应用 包括阿尔茨海默病和相关痴呆（ADRD）的生物标志物，3）检查 环境暴露的生物标志物（例如污染、有毒物质、恶劣天气），以及4）增加 代表性不足的人口的生物社会数据和学者。为实现这些目标 网络工作将包括设计和举办一系列一般性会议和专题会议，包括 网络年度会议和年度专门互动研讨会，以及定期网络研讨会， 与主题和工作小组进行电话交谈，与个别研究进行协商，以制定数据计划 收集和处理，支持试点项目，以协调和发展计量，传播 白色文件，以分享有关新兴生物标志物的信息，并支持来自 代表性不足的人群。这一网络在上一次供资期间的增长和利用证明了这一点。 在这一时期，生物数据收集和测量是人口科学关注的一个日益增长的领域。 科学，并处于从一个有组织的网络进一步发展的关键阶段。

The goal of this renewal will be to maintain and further develop an interdisciplinary network of scientists dedicated to improving measurement of biological risk for late life health outcomes to be fielded in large representative population samples. Biological risk is defined by indicators of genomic and physiological state that increase the probability of disease, disability, loss of physical or cognitive functioning, or death. The network will continue to focus on assessing, validating, and harmonizing biological risk measurement in studies of populations; expanding geroscience measures available for use in populations; and developing methodological approaches for including complex dimensions of health in analytic models. This current project will build on the extensive progress made building an initial interdisciplinary research network (funded by NIA from 2009 to 2015) and the prior iteration of this network (2016-2021). Over the last 5 years dissemination of harmonizing information and harmonized data was a major product of the network. The network disseminated protocols for collection methods, assay methods, quality control methods, harmonization methods, basic training on relevant topics of sample collection and preparation, and analytic methods. The network promoted valid interdisciplinary and international research on the associations of social, biological, economic, and psychological factors and the biological paths leading to health outcomes common in older age in large community and national population surveys. In addition to maintaining the harmonization and training efforts made during the last funding period, the network will focus on at least 4 new activities for the 2022-2027 period. The areas of increased emphasis include: 1) harmonization of molecular (e.g. epigenetic and RNA) biomarkers of health and aging over the life course, 2) exploring emerging geroscience biomarkers for potential application in large representative studies of aging, including biomarkers of Alzheimer's disease and related dementias (ADRD), 3) examination of biomarkers of environmental exposures (e.g. pollution, toxicants, severe weather), and 4) increasing representation of biosocial data and scholars from underrepresented populations. To accomplish these goals network efforts will include designing and carrying out a series of general and topic-specific meetings including annual meetings of the network and yearly specialized interactive workshops, as well as regular webinars and calls with theme and working subgroups, consulting with individual studies to develop plans for data collection and processing, supporting pilot projects to harmonize and develop measurement, dissemination of white papers to share information about emerging biomarkers, and supporting travel for scholars from underrepresented populations. As evidenced by the growth and utilization of this network over the last funding period, biological data collection and measurement is a growing area of scientific focus in the population sciences and is at a crucial stage for further development from an organized network.