Social Circumstances and Epigenomics Promoting Health in Three Countries

社会环境和表观基因组学促进三个国家的健康

• 批准号: 10242719
• 负责人: EILEEN M CRIMMINS
• 金额: $ 57.21万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10242719
• 关键词: Address; Adult; Affect; Age; Aging; Base Sequence; Behavioral; Biological; Biological Assay; Buffers; Characteristics; Childhood; Chronic Disease; Chronic stress; Collaborations; Collection; Country; DNA Methylation; Data; Data Set; Development; Diabetes Mellitus; Disease; Economics; Education; Educational Background; Elderly; Epigenetic Process; Ethnic Origin; Event; Exposure to; Family health status; Funding; Funding Agency; Genome; Grant; Grant Review; Health; Health Policy; Health Promotion; Health and Retirement Study; Health behavior; Heart Diseases; Income; Ireland; Life; Life Cycle Stages; Link; Longitudinal Studies; Longitudinal cohort study; Measures; Methylation; Minority Groups; Modification; Molecular; Northern Ireland; Outcome; Pattern; Physical Function; Physiological; Policies; Population; Poverty; Premature Mortality; Process; Psychological Factors; Race; Recording of previous events; Research; Resources; Risk; Role; Sampling; Skin; Social isolation; Social support; Stress; Stroke; Surveys; Trauma; United States; United States National Institutes of Health; adverse childhood events; base; cognitive function; comparative; contextual factors; data harmonization; design; disability; early onset; epigenetic marker; epigenomics; experience; frailty; member; mortality; population based; potential biomarker; psychologic; research and development; resilience; response; safety net; social; social determinants; social disadvantage; social factors; socioeconomics

This project proposes an integrated set of aims and analyses of existing social and epigenetic data from three national studies of aging in the family of Health and Retirement studies (the US Health and Retirement Study (HRS), the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA), and the Irish Longitudinal Study of Aging (TILDA)); assays of existing samples to produce longitudinal epigenetic data for the three countries are also proposed. Comparative analyses based on these data will address central questions about how life circumstances in both childhood and adulthood affect epigenetic change and how different historical and life-course exposures in these countries may result in differential patterns of associations. The project will also examine how epigenetic changes in turn are associated with health after age 50. The proposal is submitted in response to the US-Ireland Research and Development Partnership, a unique research initiative involving funding agencies from the United States (US), the Republic of Ireland (RofI), and Northern Ireland (NI). Proposals are submitted to each of the three countries with funding requested for each country's participation from their respective grant agency (e.g., US NIH); grant review is done only by NIH for all three projects based on this proposal. The project will examine the links between lifetime social, economic, psychological, environmental and behavioral circumstances, and epigenetic markers related to aging and health, and subsequent health. Epigenetic modification is one of the “hallmarks” of aging, i.e. an underlying physiological change that can speedup or delay aging-related health outcomes. Faster aging is characteristic of people in adverse social circumstances and epigenetic change, particularly DNA methylation (DNAm), appears to be especially influenced by adverse social circumstances, both at early ages and at later ages. This project will be unique in evaluating how a variety of social circumstances, i.e. low levels of education and income, minority group membership, adverse childhood experiences, adult traumas, risky health behaviors, psychological states, and chronic stress, are associated with epigenetic markers in three different countries, with somewhat different historical, social and behavioral characteristics which are operating in different health policy regimes – allowing for both replication where effects are hypothesized to be similar and differentiation where they are hypothesized to differ (e.g., where risk characteristics are differentially patterned by SES). The applicants are uniquely placed with their resources to explore how socioeconomic experiences across the life course alter epigenetic profiles to influence health outcomes such as biological dysregulation, frailty, disability, chronic disease, and premature mortality. The three data sets have been harmonized for information collection from the beginning of the studies and were designed to encourage comparative analysis. They have been harmonized in the survey information and the development of the epigenetic data in the three countries. Each country has strong independent research teams who bring unique expertise and resources and a history of collaboration to this collaborative proposal.

该项目提出了一套综合的目标和分析现有的社会和表观遗传数据，从三个 美国健康与退休研究（US Health and Retirement Study） (HRS)，北方爱尔兰队列的老龄化纵向研究（NICOLA），和爱尔兰纵向 老化研究（TILDA））;现有样本的分析，以产生三个纵向表观遗传数据 各国也提出了。基于这些数据的比较分析将解决以下核心问题： 童年和成年的生活环境如何影响表观遗传变化，以及不同的历史和 在这些国家，生命过程中的接触可能导致不同的关联模式。该项目还将 研究表观遗传变化如何反过来与50岁后的健康相关。该提案提交于 对美国-爱尔兰研究与发展伙伴关系的回应，这是一项独特的研究倡议， 来自美国（US），爱尔兰共和国（RofI）和北方尔兰（NI）的资助机构。 向这三个国家中的每一个国家提交了提案，并要求为每个国家的参与提供资金 从它们各自的授权机构（例如，美国国立卫生研究院）;只有国立卫生研究院对所有三个项目进行赠款审查， 在这个提议上。该项目将研究终身社会，经济，心理， 环境和行为环境，以及与衰老和健康相关的表观遗传标记， 后续健康。表观遗传修饰是衰老的“标志”之一，即一种潜在的生理改变。 改变可以加速或延迟与衰老相关的健康结果。更快的衰老是 不利的社会环境和表观遗传变化，特别是DNA甲基化（DNAm），似乎是 特别是在幼年和晚年受到不利的社会环境的影响。该项目将 在评估各种社会情况，即教育和收入水平低，少数民族， 群体成员资格，不良的童年经历，成年创伤，危险的健康行为，心理状态， 和慢性压力，与三个不同国家的表观遗传标记有关， 在不同的卫生政策制度中运作的历史、社会和行为特征， 对于假设效应相似的复制和假设效应相似的分化， 为了不同（例如，其中风险特征由SES不同地形成）。申请人是独一无二的 利用他们的资源来探索整个生命过程中的社会经济经历如何改变表观遗传特征， 影响健康的结果，如生物失调，虚弱，残疾，慢性病，早产 mortality.从研究一开始就统一了这三个数据集，以便收集信息 旨在鼓励进行比较分析。它们在调查资料中已经统一 以及这三个国家的表观遗传学数据的发展。每个国家都有强大的独立研究 团队将独特的专业知识和资源以及合作历史带到这个合作提案中。