Social Circumstances and Epigenomics Promoting Health in Three Countries

社会环境和表观基因组学促进三个国家的健康

• 批准号: 10242719
• 负责人: EILEEN M CRIMMINS
• 金额: $ 57.21万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10242719
• 关键词: Address; Adult; Affect; Age; Aging; Base Sequence; Behavioral; Biological; Biological Assay; Buffers; Characteristics; Childhood; Chronic Disease; Chronic stress; Collaborations; Collection; Country; DNA Methylation; Data; Data Set; Development; Diabetes Mellitus; Disease; Economics; Education; Educational Background; Elderly; Epigenetic Process; Ethnic Origin; Event; Exposure to; Family health status; Funding; Funding Agency; Genome; Grant; Grant Review; Health; Health Policy; Health Promotion; Health and Retirement Study; Health behavior; Heart Diseases; Income; Ireland; Life; Life Cycle Stages; Link; Longitudinal Studies; Longitudinal cohort study; Measures; Methylation; Minority Groups; Modification; Molecular; Northern Ireland; Outcome; Pattern; Physical Function; Physiological; Policies; Population; Poverty; Premature Mortality; Process; Psychological Factors; Race; Recording of previous events; Research; Resources; Risk; Role; Sampling; Skin; Social isolation; Social support; Stress; Stroke; Surveys; Trauma; United States; United States National Institutes of Health; adverse childhood events; base; cognitive function; comparative; contextual factors; data harmonization; design; disability; early onset; epigenetic marker; epigenomics; experience; frailty; member; mortality; population based; potential biomarker; psychologic; research and development; resilience; response; safety net; social; social determinants; social disadvantage; social factors; socioeconomics

This project proposes an integrated set of aims and analyses of existing social and epigenetic data from three national studies of aging in the family of Health and Retirement studies (the US Health and Retirement Study (HRS), the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA), and the Irish Longitudinal Study of Aging (TILDA)); assays of existing samples to produce longitudinal epigenetic data for the three countries are also proposed. Comparative analyses based on these data will address central questions about how life circumstances in both childhood and adulthood affect epigenetic change and how different historical and life-course exposures in these countries may result in differential patterns of associations. The project will also examine how epigenetic changes in turn are associated with health after age 50. The proposal is submitted in response to the US-Ireland Research and Development Partnership, a unique research initiative involving funding agencies from the United States (US), the Republic of Ireland (RofI), and Northern Ireland (NI). Proposals are submitted to each of the three countries with funding requested for each country's participation from their respective grant agency (e.g., US NIH); grant review is done only by NIH for all three projects based on this proposal. The project will examine the links between lifetime social, economic, psychological, environmental and behavioral circumstances, and epigenetic markers related to aging and health, and subsequent health. Epigenetic modification is one of the “hallmarks” of aging, i.e. an underlying physiological change that can speedup or delay aging-related health outcomes. Faster aging is characteristic of people in adverse social circumstances and epigenetic change, particularly DNA methylation (DNAm), appears to be especially influenced by adverse social circumstances, both at early ages and at later ages. This project will be unique in evaluating how a variety of social circumstances, i.e. low levels of education and income, minority group membership, adverse childhood experiences, adult traumas, risky health behaviors, psychological states, and chronic stress, are associated with epigenetic markers in three different countries, with somewhat different historical, social and behavioral characteristics which are operating in different health policy regimes – allowing for both replication where effects are hypothesized to be similar and differentiation where they are hypothesized to differ (e.g., where risk characteristics are differentially patterned by SES). The applicants are uniquely placed with their resources to explore how socioeconomic experiences across the life course alter epigenetic profiles to influence health outcomes such as biological dysregulation, frailty, disability, chronic disease, and premature mortality. The three data sets have been harmonized for information collection from the beginning of the studies and were designed to encourage comparative analysis. They have been harmonized in the survey information and the development of the epigenetic data in the three countries. Each country has strong independent research teams who bring unique expertise and resources and a history of collaboration to this collaborative proposal.

该项目提出了一套综合目标，并对来自三个领域的现有社会和表观遗传数据进行了分析 国家健康与退休家庭老龄化研究（美国健康与退休研究 (HRS)、北爱尔兰老龄化纵向研究队列 (NICOLA) 和爱尔兰纵向研究 衰老研究（TILDA））；对现有样本进行分析，以产生这三个样本的纵向表观遗传数据 国家也提出了建议。基于这些数据的比较分析将解决以下核心问题： 童年和成年的生活环境如何影响表观遗传变化，以及历史和成年时期的不同如何影响表观遗传变化。 这些国家的生命全程暴露可能导致不同的关联模式。该项目还将 研究表观遗传变化如何与 50 岁后的健康相关。该提案于 对美国-爱尔兰研究与发展伙伴关系的回应，这是一项独特的研究倡议，涉及 来自美国 (US)、爱尔兰共和国 (RofI) 和北爱尔兰 (NI) 的资助机构。 向三个国家分别提交提案，并为每个国家的参与申请资金 来自各自的资助机构（例如美国国立卫生研究院）；拨款审查仅由 NIH 对所有三个项目进行 关于这个提议。该项目将研究一生的社会、经济、心理、 环境和行为环境，以及与衰老和健康相关的表观遗传标记，以及 随后的健康。表观遗传修饰是衰老的“标志”之一，即潜在的生理变化 可以加速或延缓与衰老相关的健康结果的变化。衰老速度加快是人们的特点 不利的社会环境和表观遗传变化，特别是 DNA 甲基化 (DNAm)，似乎与 尤其是在早年和晚年受到不良社会环境的影响。该项目将 在评估各种社会环境（即低教育水平和收入、少数族裔）如何 群体成员身份、不良童年经历、成人创伤、危险健康行为、心理状态、 和慢性压力，与三个不同国家的表观遗传标记相关，但有些不同 在不同的卫生政策体系中运作的历史、社会和行为特征——允许 对于假设效果相似的复制和假设效果相似的分化 不同（例如，SES 区分风险特征的情况）。申请人处于独特的地位 利用他们的资源探索生命历程中的社会经济经历如何改变表观遗传特征 影响健康结果，例如生物失调、虚弱、残疾、慢性病和早产 死亡。从研究开始就协调了这三个数据集以进行信息收集 旨在鼓励比较分析。它们已在调查信息中得到统一 以及这三个国家表观遗传数据的发展。每个国家都有强大的自主研究 为该协作提案带来独特专业知识和资源以及协作历史的团队。