UA Project: Advancing Vector-borne Disease Surveillance in American Indian Communities

UA 项目：推进美洲印第安人社区媒介传播疾病监测

• 批准号: 10438231
• 负责人: Dawn Heather Gouge
• 金额: $ 10.72万
• 依托单位: INTER TRIBAL COUNCIL OF ARIZONA, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10438231
• 关键词: American Indians; Communities; Disease Surveillance; Grant; Native American Research Center for Health; Vector-transmitted infectious disease

Project Summary/Abstract The Inter Tribal Council of Arizona, Cocopah Environmental Protection Office staff, medical entomologists from the University of California, vector-borne disease researchers from the University of Arizona and other community partners will build upon existing participatory research and outreach partnerships in the proposed project. Arizona often ranks amongst the highest in West Nile virus infection and related deaths relative to other states. Additionally, high populations of the invasive yellow fever mosquito Aedes aegypti in communities along southern border areas makes mosquito and pathogen surveillance critically important. Ae. aegypti is the primary vector of dengue and Zika viruses which circulate in the neighboring border states of Sonora and Baja California, Mexico. Ticks are important vectors causing human disease. Among the most significant is Rocky Mountain spotted fever (RMSF), a bacterial infection caused by Rickettsia rickettsii, which kills more people in North America than any other tickborne disease. Native American populations are disproportionately impacted. Since the first locally acquired case was identified in Arizona in 2003, the disease has become endemic in many Native American communities. In Arizona, R. rickettsii is vectored by the brown dog tick Rhipicephalus sanguineus and to date there have been more than 436 cases of RMSF with a case fatality rate of 10%, which is 15 times the national rate for this disease. There have been no surveillance efforts for vector or pathogen prevalence outside of post-epidemic events. Supportive efforts are needed to identify high-risk surveillance gaps, undertake vector and pathogen prevalence assessments, and generate access to essential infrastructure and services in the short-term. Vector-borne Disease Research Committees (VbDRC) within collaborating tribal communities will direct high priority vector surveillance and inform Tribal leadership of technical findings. Creation of Vector Risk Mitigation Plans and relevant community specific practicum training will be provided for tribal environmental health, public health and medical practitioners serving communities. Additionally, investment in Native American students through financially supported vector research experiences will help build the future public and environmental health workforce. There is strong evidence that student research experiences improve educational persistence, thus UA faculty and VbDRC members will mentor Native American students through community-based research projects.

项目总结/摘要 亚利桑那州部落间理事会、可可帕环境保护办公室工作人员、来自 来自加州大学、亚利桑那大学和其他 社区合作伙伴将在拟议的 项目 亚利桑那州通常是西尼罗河病毒感染和相关死亡人数最高的州之一。 此外，在沿着的社区， 南部边境地区的蚊子和病原体监测至关重要。AE.埃及是 登革热和寨卡病毒的主要传播媒介，在邻近的边境州索诺拉和巴哈传播 加州，墨西哥。蜱是引起人类疾病的重要媒介。其中最重要的是洛基 山地斑疹热（RMSF），一种由立克次体引起的细菌感染， 比任何其他蜱传疾病。美洲原住民人口受到不成比例的影响。 自2003年在亚利桑那州发现第一例当地获得性病例以来，该病已成为亚利桑那州的地方病。 许多美国原住民社区。在亚利桑那州，R。立克次氏体是由棕色狗蜱扇头蜱传播的 迄今为止，已有超过436例RMSF病例，病死率为10%， 是全国发病率的15倍没有对病媒或病原体进行监测 流行病后事件之外的流行。 需要作出支助性努力，以查明高风险监测差距， 流行率评估，并在短期内提供基本基础设施和服务。 合作部落社区内的病媒传播疾病研究委员会将指导高 优先开展病媒监测，并向部落领导人通报技术调查结果。创建媒介风险缓解 计划和相关的社区具体实习培训将提供部落环境卫生，公共 为社区服务的卫生和医疗从业人员。此外，对美国原住民学生的投资 通过财政支持的媒介研究经验将有助于建立未来的公共和环境 卫生劳动力。有强有力的证据表明，学生的研究经验提高教育的持久性， 因此，UA教师和VbDRC成员将通过基于社区的 研究项目。