Comparison of Exercise Mode on Disruptions in Calcium Homeostasis

运动模式对钙稳态破坏的比较

• 批准号: 10437654
• 负责人: Sarah J Wherry
• 金额: --
• 依托单位: VA EASTERN COLORADO HEALTH CARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10437654
• 关键词: Acute; Address; Adult; Age; Age-Related Bone Loss; Aging; Area; Attenuated; Award; Biological Markers; Blood specimen; Bone Density; Bone Resorption; C-telopeptide; Calcium; Calcium ion; Cardiometabolic Disease; Clinical; Collagen Type I; Cyclophosphamide; Data; Diabetes Mellitus; Educational Status; Elderly; Exercise; Future; Goals; Guidelines; Health; Heart Diseases; Heart Rate; Homeostasis; Hour; Intervention; Knowledge; Lead; Life; Life Style; Measures; N-terminal; Orthopedics; Osteogenesis; Osteoporosis; Outcome; PTH gene; Participant; Population; Prevention strategy; Procollagen; Quality of life; Randomized; Recommendation; Research; Risk; Serum; Stimulus; Testing; Time; Type I Procollagen; Veterans; Walking; Weight; Weight-Bearing state; Woman; aged; bone; bone health; bone loss; bone turnover; calcium supplementation; cardiometabolic risk; cardiometabolism; design; endurance exercise; exercise intensity; exercise intervention; exercise prescription; experience; experimental study; fitness; fracture risk; functional independence; improved; innovation; lifestyle intervention; men; mode of exercise; novel; osteoporosis with pathological fracture; preservation; prevent; response; response biomarker; sex; treadmill

Endurance exercise is frequently recommended as a means to reduce the risk of cardiometabolic diseases and to reduce the risk of osteoporotic fracture. However, bone does not always adapt in the way that would be expected, and there is evidence that endurance exercise may lead to bone loss under certain conditions. It is our contention that disruptions in calcium homeostasis during exercise, resulting in decreases in serum ionized calcium (iCa) and increases in parathyroid hormone (PTH) and c-telopeptide of type I collagen (CTX; a marker of bone resorption) at the onset of exercise, may be responsible for the lack of improvements in bone mineral density that are anticipated. Acute studies in this area have predominantly focused on young, healthy adults, primarily men, during stationary cycling exercise. Few studies have been conducted in older adults, but those studies have found that older adults experience similar disruptions in calcium homeostasis in response to an acute bout of endurance exercise. Preliminary comparisons of our studies, as well as research from other labs, also suggests that that mode of exercise conducted during these acute exercise bouts may be an important determining factor in the catabolic bone response to exercise. It appears that weight-bearing exercise (i.e., treadmill) results in smaller increases in PTH and CTX compared to weight-supported exercise (i.e., stationary cycling). This has never been tested using a within-subjects design, so it is unclear if these observed differences are due to the mode of exercise, lab-to-lab differences, or other underlying factors. To address this gap in knowledge, 30 Veterans (15 men, 15 women), aged 60+ years, will complete two 1-hour acute exercise bouts: 1) brisk treadmill walking at 70-80% of maximal heart rate; 2) vigorous stationary cycling at 70-80% maximal heart rate. Blood samples will be collected to measure iCa, PTH, CTX and procollagen type I n- terminal propeptide (P1NP) before, during, and after each exercise bout. The order of the exercise bouts will be randomized and counter-balanced. The primary aim is to determine if mode of exercise results in a differential bone biomarker response in older Veterans. This information is essential for understanding how future exercise interventions should be designed to benefit both cardiometabolic health and bone health. This is especially relevant to Veteran health due to the high burden of both cardiometabolic diseases (e.g., diabetes, heart disease) in the population, as well as evidence of increased osteoporotic fracture risk. The proposed research is significant because it is addressing a knowledge gap that has prevented the ability to design exercise and lifestyle interventions aimed at preserving multiple components of Veteran health, which could have a lasting impact on Veteran quality of life and functional independence. The proposed research is innovative because it is testing a novel hypothesis, the mode of exercise on disruptions in calcium homeostasis, in a population that could greatly benefit from the knowledge to be gained. While the proposed research is an acute study, the results generated will be used to design future clinical interventions for Veteran health. Long-term, information gained from this research will help to define the optimal exercise prescription to improve cardiometabolic without compromising bone health aging Veterans.

耐力运动经常被推荐为降低心脏代谢疾病风险的一种手段