Prenatal diet-stress interactions and the maternal metabolic response in human pregnancy

产前饮食与压力的相互作用以及人类妊娠期间的母体代谢反应

• 批准号: 10437664
• 负责人: Karen Lindsay
• 金额: $ 24.4万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10437664
• 关键词: Accounting; Acute; Address; Adipose tissue; Affect; Age; Applications Grants; Behavioral; Biochemical; Biological; Biological Assay; Biological Process; Biology; Biometry; Biophysics; Blood specimen; Body Composition; Body mass index; Brain; Child; Clinical; Clinical Sciences; Clinical and Translational Science Awards; Consumption; Cross-Over Studies; Crossover Design; Data; Development; Development Plans; Diet; Dietary Intervention; Dietary intake; Disease; Dose; Ecological momentary assessment; Enrollment; Environment; Ethnic Origin; Exhibits; Exposure to; Fasting; Fatty Acids; Fetal Development; Funding; Future; Gastric Emptying; Gestational Diabetes; Gluconeogenesis; Glucose; Glycemic Index; Goals; Growth; Health; Healthy Eating; Homeostasis; Hour; Human; Hydrocortisone; Individual; Individual Differences; Infant; Institutes; Insulin; Insulin Resistance; Knowledge; Liver; Maternal Behavior; Maternal and Child Health; Measures; Mentors; Mentorship; Metabolic; Metabolic Diseases; Metabolism; Methodology; Methods; Modeling; Moods; Mothers; Nonesterified Fatty Acids; Nutritional Science; Observational Study; Outcome; Pathway interactions; Peripheral; Phase; Physical activity; Physiological Processes; Placebos; Play; Pregnancy; Pregnant Women; Prenatal Nutrition; Process; Protocols documentation; Psychosocial Stress; Race; Randomized; Regulation; Research; Research Design; Research Personnel; Resources; Role; Scientist; Sleep; Smoking; Socioeconomic Status; Standardization; Stress; Structure; Supervision; System; Technical Expertise; Technology; Testing; Third Pregnancy Trimester; Time; Tissues; Training; Training Activity; Translational Research; Trier Social Stress Test; Triglycerides; Unhealthy Diet; United States National Institutes of Health; Variant; Visit; base; biological adaptation to stress; career; career development; cohort; community engagement; data repository; design; dietary; disorder risk; experience; experimental study; fetal; fetal programming; follow-up; gestational weight gain; improved; indexing; infancy; inter-individual variation; laboratory facility; maternal hyperglycemia; maternal stress; meetings; metabolic profile; mother nutrition; non-diabetic; novel; obstetrical complication; offspring; parity; population based; prenatal; prenatal stress; prepregnancy; programs; prospective; psychologic; psychosocial; response; saliva sample; skeletal tissue; smartphone based assessment; sociodemographics; stress reactivity; stress reduction; stressor; western diet

ABSTRACT RESEARCH SUMMARY: Maternal glucose-insulin homeostasis in pregnancy represents one of the most important physiological processes for maternal and child health outcomes. Although maternal diet is a key regulator of this process, its effects vary widely across individuals, suggesting other moderating factors may be at play. Based on studies that demonstrate diet and stress interact at various biological and behavioral levels, and the biological response to stress alters glucose-insulin homeostasis, I submit that stress likely represents a moderator of considerable significance in pregnancy. Yet, existing studies of pregnancy have not considered their combined effects. The primary goal of this K99/R00 project is to test the hypothesis that maternal prenatal stress may exacerbate the unfavorable effects of unhealthy diet on gestational glucose-insulin homeostasis. I aim to address this knowledge gap using two complementary approaches. Aim 1: To establish the independent effect of prenatal stress, and the interaction effect of prenatal diet quality and stress, on indicators of fasting insulin resistance (HOMA-IR and Adipo-IR). Aim 2: To conduct a randomized, controlled, cross-over study to experimentally test whether stress exposure potentiates the glycemic and fatty acid response to a standardized meal (indicative of postprandial insulin resistance) among pregnant women. CANDIDATE: My background expertise is maternal nutrition in pregnancy and the elucidation of prenatal factors that influence fetal development and child metabolic health. My research focus has now expanded to incorporate the role of prenatal stress and stress biology. My career goal is to develop and establish myself as an independent, trans- disciplinary investigator addressing key questions related to a) the combined effects of maternal diet and stress on pre-natal metabolism, and b) how prenatal biology may be altered via maternal behavior/psychosocial state for improved fetal programming outcomes. My short-term goals are a) to understand the prenatal biochemical effects of maternal diet-stress interplay, and b) to advance this field of research from observational to experimental study design. CAREER DEVELOPMENT PLAN: My training plan is designed to allow me to acquire the professional and technical skills necessary for a successful transition to independence as a trans-disciplinary investigator. It includes regular meetings, structured coursework, focused tutorials, practical training and research management under the guidance of an expert mentorship team, led by Pathik Wadhwa (prenatal stress, DOHaD), and co-mentors Sonja Entringer (fetal metabolic programming, stress biology), Janet King (prenatal nutrition, metabolism) and Daniel Gillen (biostatistics). ENVIRONMENT: The UC Irvine Development, Health and Disease Research Program (DHDRP) offers myriad resources, including an inter-disciplinary team to provide an intellectually productive environment, research staff, office, and laboratory facilities, and experiential training in state-of-the-art methods for studies of maternal-placental-fetal bi- ology, fetal development, and offspring body composition, metabolic function and brain development. The UCI Institute of Clinical and Translational Science, funded by the NIH Clinical & Translational Sciences Award program, provides expert support to junior scientists on research design, biostatistics, community engagement and bioassay platforms.

摘要

项目成果

Prenatal Cortisol Levels Estimation Using Heart Rate and Heart Rate Variability: A Weak Supervised Learning Based Approach.

使用心率和心率变异性估计产前皮质醇水平：一种基于弱监督学习的方法。

• DOI: 10.1109/embc48229.2022.9871718
• 发表时间: 2022
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: Cao,Rui;Huang,Yong;Rahmani,AmirM;Lindsay,Karen
• 通讯作者: Lindsay,Karen

Feasibility and Acceptability of a Mindfulness-Based Smartphone App among Pregnant Women with Obesity.

• DOI: 10.3390/ijerph20075421
• 发表时间: 2023-04-06
• 期刊: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
• 作者: Ward, Kerrie;Herekar, Anjali;Wang, Peiyi;Lindsay, Karen L
• 通讯作者: Lindsay, Karen L

Maternal Stress Potentiates the Effect of an Inflammatory Diet in Pregnancy on Maternal Concentrations of Tumor Necrosis Factor Alpha.

• DOI: 10.3390/nu10091252
• 发表时间: 2018-09-06
• 期刊: Nutrients
• 影响因子: 5.9
• 作者: Lindsay KL;Buss C;Wadhwa PD;Entringer S
• 通讯作者: Entringer S

Maternal Metabolomic Profile and Fetal Programming of Offspring Adiposity: Identification of Potentially Protective Lipid Metabolites.

• DOI: 10.1002/mnfr.201700889
• 发表时间: 2019-01
• 期刊: Molecular nutrition & food research
• 影响因子: 5.2
• 作者: Hellmuth C;Lindsay KL;Uhl O;Buss C;Wadhwa PD;Koletzko B;Entringer S
• 通讯作者: Entringer S

Maternal C3 complement and C-reactive protein and pregnancy and fetal outcomes: A secondary analysis of the PEARS RCT-An mHealth-supported, lifestyle intervention among pregnant women with overweight and obesity.

• DOI: 10.1016/j.cyto.2021.155748
• 发表时间: 2022-01
• 期刊: CYTOKINE
• 影响因子: 3.8
• 作者: Kennelly, Maria A.;Killeen, Sarah Louise;Phillips, Catherine M.;Alberdi, Gouiri;Lindsay, Karen L.;Mehegan, John;Cronin, Martina;McAuliffe, Fionnuala M.
• 通讯作者: McAuliffe, Fionnuala M.